18 F-Flortaucipir in TDP-43 associated frontotemporal dementia

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Smith, R.Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups (author)

18 F-Flortaucipir in TDP-43 associated frontotemporal dementia

Article/chapterEnglish2019

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2019-04-15
Springer Science and Business Media LLC,2019

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LIBRIS-ID:oai:lup.lub.lu.se:855a6f2d-c625-422b-8c3d-7141ef1ed91e
https://lup.lub.lu.se/record/855a6f2d-c625-422b-8c3d-7141ef1ed91eURI
https://doi.org/10.1038/s41598-019-42625-9DOI

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Language:English
Summary in:English

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Retention of 18 F-Flortaucipir is reportedly increased in the semantic variant of primary progressive aphasia (svPPA), which is dominated by TDP-43 pathology. However, it is unclear if 18 F-Flortaucipir is also increased in other TDP-43 diseases, such as bvFTD caused by a C9orf72 gene mutation. We therefore recruited six C9orf72 expansion carriers, six svPPA patients, and 54 healthy controls. All underwent 18 F-Flortaucipir PET and MRI scanning. Data from 39 Alzheimer’s Disease patients were used for comparison. PET tracer retention was assessed both at the region-of-interest (ROI) and at the voxel-level. Further, autoradiography using 3 H-Flortaucipir was performed. SvPPA patients exhibited higher 18 F-Flortaucipir retention in the lateral temporal cortex bilaterally according to ROI- and voxel-based analyses. In C9orf72 patients, 18 F-Flortaucipir binding was slightly increased in the inferior frontal lobes in the ROI based analysis, but these results were not replicated in the voxel-based analysis. Autoradiography did not show specific binding in svPPA cases or in C9orf72-mutation carriers. In conclusion, temporal lobe 18 F-Flortaucipir retention was observed in some cases of svPPA, but the uptake was of a lower magnitude compared to AD dementia. C9orf72-mutation carriers exhibited none or limited 18 F-Flortaucipir retention, indicating that 18 F-Flortaucipir binding in TDP-43 proteinopathies is not a general TDP-43 related phenomenon.

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Santillo, A. F.Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups(Swepub:lu)med-ast (author)
Waldö, M. LandqvistLund University,Lunds universitet,Kliniska Vetenskaper, Helsingborg,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Psykiatri, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Clinical Sciences, Helsingborg,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Psychiatry (Lund),Section IV,Department of Clinical Sciences, Lund(Swepub:lu)med-mlv (author)
Strandberg, O.Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups(Swepub:lu)teor-osn (author)
Berron, D.Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups(Swepub:lu)da1401be (author)
Vestberg, S.Lund University,Lunds universitet,Institutionen för psykologi,Samhällsvetenskapliga institutioner och centrumbildningar,Samhällsvetenskapliga fakulteten,Department of Psychology,Departments of Administrative, Economic and Social Sciences,Faculty of Social Sciences(Swepub:lu)psyk-vsu (author)
van Westen, D.Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Neuroradiologi,Clinical Memory Research,Lund University Research Groups,Neuroradiology(Swepub:lu)ront-dva (author)
van Swieten, J.Erasmus University Medical Center (author)
Honer, M.F. Hoffmann-La Roche AG (author)
Hansson, O.Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital(Swepub:lu)mphy-ohn (author)
Klinisk minnesforskningForskargrupper vid Lunds universitet (creator_code:org_t)

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In:Scientific Reports: Springer Science and Business Media LLC9:12045-2322

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Neurosciences

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