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  • Patin, EtiennePasteur Institute (author)

Natural variation in the parameters of innate immune cells is preferentially driven by genetic factors

  • Article/chapterEnglish2018

Publisher, publication year, extent ...

  • 2018-02-23
  • Springer Science and Business Media LLC,2018

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:856ab6b2-b1f1-40a6-aa60-1f2d51d455cf
  • https://lup.lub.lu.se/record/856ab6b2-b1f1-40a6-aa60-1f2d51d455cfURI
  • https://doi.org/10.1038/s41590-018-0049-7DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • The quantification and characterization of circulating immune cells provide key indicators of human health and disease. To identify the relative effects of environmental and genetic factors on variation in the parameters of innate and adaptive immune cells in homeostatic conditions, we combined standardized flow cytometry of blood leukocytes and genome-wide DNA genotyping of 1,000 healthy, unrelated people of Western European ancestry. We found that smoking, together with age, sex and latent infection with cytomegalovirus, were the main non-genetic factors that affected variation in parameters of human immune cells. Genome-wide association studies of 166 immunophenotypes identified 15 loci that showed enrichment for disease-associated variants. Finally, we demonstrated that the parameters of innate cells were more strongly controlled by genetic variation than were those of adaptive cells, which were driven by mainly environmental exposure. Our data establish a resource that will generate new hypotheses in immunology and highlight the role of innate immunity in susceptibility to common autoimmune diseases.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Hasan, MilenaPasteur Institute (author)
  • Bergstedt, JacobLund University,Lunds universitet,Institutionen för reglerteknik,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Automatic Control,Departments at LTH,Faculty of Engineering, LTH,Pasteur Institute(Swepub:lu)cont-jan (author)
  • Rouilly, VincentPasteur Institute (author)
  • Libri, ValentinaPasteur Institute (author)
  • Urrutia, AlejandraPasteur Institute,Genentech, Inc (author)
  • Alanio, CécilePasteur Institute (author)
  • Scepanovic, PetarSwiss Federal Institute of Technology,Swiss Institute for Bioinformatics (SIB) (author)
  • Hammer, ChristianSwiss Institute for Bioinformatics (SIB),Swiss Federal Institute of Technology (author)
  • Jönsson, FriederikeSwiss Federal Institute of Technology (author)
  • Beitz, BenoîtPasteur Institute (author)
  • Quach, HelenePasteur Institute (author)
  • Lim, Yoong WearnGenentech, Inc (author)
  • Hunkapiller, JulieGenentech, Inc (author)
  • Zepeda, MaggeGenentech, Inc (author)
  • Green, CherieGenentech, Inc (author)
  • Piasecka, BarbaraPasteur Institute (author)
  • Leloup, ClaireGenentech, Inc (author)
  • Rogge, LarsPasteur Institute (author)
  • Huetz, FrançoisParis Descartes University,Pasteur Institute (author)
  • Peguillet, IsabelleCurie Institute, Paris (author)
  • Lantz, OlivierCurie Institute, Paris (author)
  • Fontes, MagnusLund University,Lunds universitet,Matematik LTH,Matematikcentrum,Institutioner vid LTH,Lunds Tekniska Högskola,Mathematics (Faculty of Engineering),Centre for Mathematical Sciences,Departments at LTH,Faculty of Engineering, LTH,Pasteur Institute(Swepub:lu)math-mfo (author)
  • Santo, James P.Pasteur Institute (author)
  • Thomas, StéphaniePasteur Institute (author)
  • Fellay, JacquesSwiss Federal Institute of Technology,Genentech, Inc (author)
  • Duffy, DarraghPasteur Institute (author)
  • Quintana-Murci, LluisPasteur Institute (author)
  • Albert, Matthew LPasteur Institute,Genentech, Inc (author)
  • Pasteur InstituteInstitutionen för reglerteknik (creator_code:org_t)
  • Milieu Intérieur Consortium

Related titles

  • In:Nature Immunology: Springer Science and Business Media LLC19, s. 302-3141529-29081529-2916

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