Sökning: WFRF:(Duffy Darragh) >
Immune system adapt...
Immune system adaptation during gender-affirming testosterone treatment
-
- Lakshmikanth, Tadepally (författare)
- Department of Women's and Children's Health, Karolinska Institutet, Solna, Sweden
-
- Consiglio, Camila (författare)
- Department of Women's and Children's Health, Karolinska Institutet, Solna, Sweden; Department of Laboratory Medicine, Lund University, Lund, Sweden
-
- Sardh, Fabian (författare)
- Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Solna, Sweden; Science for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
-
visa fler...
-
- Forlin, Rikard (författare)
- Department of Women's and Children's Health, Karolinska Institutet, Solna, Sweden
-
- Wang, Jun (författare)
- Department of Women's and Children's Health, Karolinska Institutet, Solna, Sweden
-
- Tan, Ziyang (författare)
- Department of Women's and Children's Health, Karolinska Institutet, Solna, Sweden
-
- Barcenilla, Hugo (författare)
- Department of Women's and Children's Health, Karolinska Institutet, Solna, Sweden
-
- Rodriguez, Lucie (författare)
- Department of Women's and Children's Health, Karolinska Institutet, Solna, Sweden
-
- Sugrue, Jamie (författare)
- Translational Immunology Unit, Institut Pasteur, Paris, France
-
- Noori, Peri (författare)
- Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Solna, Sweden
-
- Ivanchenko, Margarita (författare)
- Department of Women's and Children's Health, Karolinska Institutet, Solna, Sweden
-
- Piñero Páez, Laura (författare)
- Department of Women's and Children's Health, Karolinska Institutet, Solna, Sweden
-
- Gonzalez, Laura (författare)
- Department of Women's and Children's Health, Karolinska Institutet, Solna, Sweden
-
- Habimana Mugabo, Constantin (författare)
- Department of Women's and Children's Health, Karolinska Institutet, Solna, Sweden
-
- Johnsson, Anette (författare)
- Department of Women's and Children's Health, Karolinska Institutet, Solna, Sweden
-
- Ryberg, Henrik (författare)
- Department of Clinical Chemistry, Sahlgrenska University Hospital, Gothenburg, Sweden; Department of Internal Medicine and Clinical Nutrition, University of Gothenburg, Gothenburg, Sweden
-
- Hallgren, Åsa (författare)
- Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Solna, Sweden
-
- Pou, Christian (författare)
- Department of Women's and Children's Health, Karolinska Institutet, Solna, Sweden
-
- Chen, Yang (författare)
- Department of Women's and Children's Health, Karolinska Institutet, Solna, Sweden
-
- Mikeš, Jaromír (författare)
- Department of Women's and Children's Health, Karolinska Institutet, Solna, Sweden
-
- James, Anna (författare)
- Department of Women's and Children's Health, Karolinska Institutet, Solna, Sweden
-
- Dahlqvist, Per (författare)
- Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden
-
- Wahlberg, Jeanette, 1969- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper
-
- Hagelin, Anders (författare)
- ANOVA, Karolinska University Hospital, Stockholm, Sweden; Department of Medicine, Karolinska Institutet, Stockholm, Sweden
-
- Holmberg, Mats (författare)
- ANOVA, Karolinska University Hospital, Stockholm, Sweden; Department of Medicine, Karolinska Institutet, Stockholm, Sweden
-
- Degerblad, Marie (författare)
- ANOVA, Karolinska University Hospital, Stockholm, Sweden; Department of Molecular Medicine and Surgery, Karolinska Institutet, Solna, Sweden
-
- Isaksson, Magnus (författare)
- Department of Medical Sciences, Uppsala University, Uppsala, Sweden
-
- Duffy, Darragh (författare)
- Translational Immunology Unit, Institut Pasteur, Paris, France
-
- Kämpe, Olle (författare)
- Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Solna, Sweden; Department of Endocrinology, Metabolism and Diabetes, Karolinska University Hospital, Stockholm, Sweden
-
- Landegren, Nils (författare)
- Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Solna, Sweden; Science for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
-
- Brodin, Petter (författare)
- Department of Women's and Children's Health, Karolinska Institutet, Solna, Sweden; Medical Research Council, Laboratory of Medical Sciences, London, UK; Department of Immunology and Inflammation, Imperial College London, London, UK
-
visa färre...
-
(creator_code:org_t)
- Nature Publishing Group, 2024
- 2024
- Engelska.
-
Ingår i: Nature. - : Nature Publishing Group. - 0028-0836 .- 1476-4687. ; 633:8028, s. 155-164
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Infectious, inflammatory and autoimmune conditions present differently in males and females. SARS-CoV-2 infection in naive males is associated with increased risk of death, whereas females are at increased risk of long COVID, similar to observations in other infections. Females respond more strongly to vaccines, and adverse reactions are more frequent, like most autoimmune diseases. Immunological sex differences stem from genetic, hormonal and behavioural factors but their relative importance is only partially understood. In individuals assigned female sex at birth and undergoing gender-affirming testosterone therapy (trans men), hormone concentrations change markedly but the immunological consequences are poorly understood. Here we performed longitudinal systems-level analyses in 23 trans men and found that testosterone modulates a cross-regulated axis between type-I interferon and tumour necrosis factor. This is mediated by functional attenuation of type-I interferon responses in both plasmacytoid dendritic cells and monocytes. Conversely, testosterone potentiates monocyte responses leading to increased tumour necrosis factor, interleukin-6 and interleukin-15 production and downstream activation of nuclear factor kappa B-regulated genes and potentiation of interferon-γ responses, primarily in natural killer cells. These findings in trans men are corroborated by sex-divergent responses in public datasets and illustrate the dynamic regulation of human immunity by sex hormones, with implications for the health of individuals undergoing hormone therapy and our understanding of sex-divergent immune responses in cisgender individuals.
Ämnesord
- NATURVETENSKAP -- Biologi -- Immunologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Immunology (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
-
Nature
(Sök värdpublikationen i LIBRIS)
Till lärosätets databas
- Av författaren/redakt...
-
Lakshmikanth, Ta ...
-
Consiglio, Camil ...
-
Sardh, Fabian
-
Forlin, Rikard
-
Wang, Jun
-
Tan, Ziyang
-
visa fler...
-
Barcenilla, Hugo
-
Rodriguez, Lucie
-
Sugrue, Jamie
-
Noori, Peri
-
Ivanchenko, Marg ...
-
Piñero Páez, Lau ...
-
Gonzalez, Laura
-
Habimana Mugabo, ...
-
Johnsson, Anette
-
Ryberg, Henrik
-
Hallgren, Åsa
-
Pou, Christian
-
Chen, Yang
-
Mikeš, Jaromír
-
James, Anna
-
Dahlqvist, Per
-
Wahlberg, Jeanet ...
-
Hagelin, Anders
-
Holmberg, Mats
-
Degerblad, Marie
-
Isaksson, Magnus
-
Duffy, Darragh
-
Kämpe, Olle
-
Landegren, Nils
-
Brodin, Petter
-
visa färre...
- Om ämnet
-
- NATURVETENSKAP
-
NATURVETENSKAP
-
och Biologi
-
och Immunologi
- Artiklar i publikationen
-
Nature
- Av lärosätet
-
Örebro universitet