WFRF:(Wolkowitz Owen M.)
Sökning: WFRF:(Wolkowitz Owen M.) > (2024) > Peripheral serotoni...
Peripheral serotonin levels as a predictor of antidepressant treatment response : A systematic review
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- Holck, Amanda (författare)
- Lund University,Lunds universitet,Psykiatri, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Enheten för klinisk suicidforskning,Forskargrupper vid Lunds universitet,Psychiatry (Lund),Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Unit for clinical suicide research,Lund University Research Groups,Skåne University Hospital
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- Movahed, Pouya (författare)
- Lund University,Lunds universitet,Psykiatri, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Enheten för psykiatrisk neuromodulering (PNU),Forskargrupper vid Lunds universitet,Psychiatry (Lund),Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Psychiatric Neuromodulation Unit (PNU),Lund University Research Groups,Skåne University Hospital
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- Westrin, Åsa (författare)
- Lund University,Lunds universitet,Psykiatri, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Enheten för klinisk suicidforskning,Forskargrupper vid Lunds universitet,Psychiatry (Lund),Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Unit for clinical suicide research,Lund University Research Groups,Region Skåne
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- 2024
- 2024
- Engelska.
- Ingår i: Progress in Neuro-Psychopharmacology and Biological Psychiatry. - 0278-5846. ; 133
- Forskningsöversikt (refereegranskat)
Abstract
Ämnesord
Stäng
- There are currently no reliable biomarkers to predict clinical response to pharmacological treatments of depressive disorders. Peripheral blood 5-hydroxytryptamine (5-HT; serotonin) has been suggested as a biomarker of antidepressant treatment response, but there has not been an attempt to systematically summarize and evaluate the scientific evidence of this hypothesis. In this systematic review we searched MEDLINE, Embase, PsycINFO, and the Cochrane Central Register of Controlled Trials. Twenty-six relevant studies investigating peripheral 5-HT as an antidepressant biomarker were identified. In all, we did not find robust support for an association between baseline 5-HT and treatment response. Several larger studies with lower risk of bias, however, showed that higher baseline 5-HT was associated with a greater antidepressant response to SSRIs, prompting future studies to investigate this hypothesis. Our results also confirm previous reports that SSRI treatment is associated with a decrease in peripheral 5-HT levels; however, we were not able to confirm that larger decreases of 5-HT are associated with better treatment outcome as results were inconclusive.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Nyckelord
- 5-hydroxytryptamine
- Antidepressant treatment
- Biomarkers
- Depressive disorders
- SSRIs
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- Progress in Neuro-Psychopharmacology and Biological Psychiatry (Sök värdpublikationen i LIBRIS)
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- Av författaren/redakt...
- Holck, Amanda
- Movahed, Pouya
- Westrin, Åsa
- Wolkowitz, Owen ...
- Lindqvist, Danie ...
- Asp, Marie
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