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Isatis tinctoria L....
Isatis tinctoria L. combined with co-stimulatory molecules blockade prolongs survival of cardiac allografts in alloantigen-primed mice
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Kang, Xiangpeng (author)
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Chen, Jibing (author)
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Qin, Qing (author)
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Wang, Feng (author)
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Wang, Yongzhi (author)
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Lan, Tianshu (author)
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Xu, Shuo (author)
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Wang, Feiyu (author)
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Xia, Junjie (author)
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- Ekberg, Henrik (author)
- Lund University,Lunds universitet,Enheten för forskning kring njurfunktion och njursjukdom,Kirurgi,Forskargrupper vid Lunds universitet,Renal Research Unit,Surgery,Lund University Research Groups
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Qi, Zhongquan (author)
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Liu, Zhongchen (author)
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(creator_code:org_t)
- Elsevier BV, 2010
- 2010
- English.
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In: Transplant Immunology. - : Elsevier BV. - 1878-5492 .- 0966-3274. ; 23:1-2, s. 34-39
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http://dx.doi.org/10...
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Abstract
Subject headings
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- Memory T cells present a unique challenge in transplantation. Although memory T cells express robust immune responses to invading pathogens. they may be resistant to the effects of immunosuppressive therapies used to prolong graft survival. In previous studies, we found that compound K. the synthesized analogue of highly unsaturated fatty acids from Isatis tinctoria L., reduced acute cardiac allograft rejection in mice (Wang et al., 2009 [1]). Here, we further investigated the effect of compound K on cardiac allograft rejection in alloantigen-primed mice. We found that compound K significantly inhibited CD4(+) and CD8(+) memory T cells proliferation in a mixed lymphocyte reaction (MLR). In vivo, compound K combined with anti-CD154 and anti-LFA-1 monoclonal antibodies (mAbs) significantly extended the survival time of heart grafts in alloantigen-primed mice with no obvious toxic side effects. Furthermore, our data suggests that compound K works by reducing the expression of both IL-2 and IFN-gamma within the graft rather than enhancing expression of regulatory T cells (Tregs). Compound K can also inhibit the alloresponses of memory T cells, while increasing the proportion of CD4(+) memory T cells in the spleen of the recipients and significantly reducing the level of alloantibodies in the serum. Our study highlights the unique immune effects of compound K that may be further explored for clinical use in extending the survival of transplant grafts. (C) 2010 Elsevier B.V. All rights reserved.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Keyword
- Isatis tinctoria L.
- Memory T cells
- Alloantigen-primed mice
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Kang, Xiangpeng
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Chen, Jibing
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Qin, Qing
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Wang, Feng
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Wang, Yongzhi
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Lan, Tianshu
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show more...
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Xu, Shuo
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Wang, Feiyu
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Xia, Junjie
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Ekberg, Henrik
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Qi, Zhongquan
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Liu, Zhongchen
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Urology and Neph ...
- Articles in the publication
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Transplant Immun ...
- By the university
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Lund University