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Age at menarche and...
Age at menarche and menopause and breast cancer risk in the International BRCA1/2 Carrier Cohort Study
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- Chang-Claude, Jenny (author)
- German Cancer Research Centre
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- Andrieu, Nadine (author)
- Institut Gustave Roussy,Curie Institute, Paris
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- Rookus, Matti (author)
- Netherlands Cancer Institute
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- Brohet, Richard (author)
- Netherlands Cancer Institute
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- Antoniou, Antonis C. (author)
- University of Cambridge
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- Peock, Susan (author)
- University of Cambridge
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- Davidson, Rosemarie (author)
- Royal Hospital for Sick Children, Glasgow,Royal Marsden Hospital, London
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- Izatt, Louise (author)
- Guy's and St Thomas' NHS Foundation Trust
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- Cole, Trevor (author)
- Birmingham Women’s Hospital Healthcare NHS Trust
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Noguès, Catherine (author)
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- Luporsi, Elisabeth (author)
- Institute Cancer De Lorraine - Alexis Vautrin
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- Huiart, Laetitia (author)
- Institut Paoli-Calmettes
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- Hoogerbrugge, Nicoline (author)
- Radboud University Nijmegen,Radboud University Medical Center
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- Van Leeuwen, Flora E. (author)
- Netherlands Cancer Institute
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- Osorio, Ana (author)
- Spanish National Cancer Research Center (CNIO)
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- Eyfjord, Jorunn (author)
- Icelandic Cancer Society
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- Radice, Paolo (author)
- Istituto Nazionale dei Tumori
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Goldgar, David E. (author)
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- Easton, Douglas F. (author)
- University of Cambridge
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Wagner, Teresa (author)
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Korn, Verena (author)
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Gerdes, Anne Marie (author)
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Olah, Edith (author)
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Eyford, Jorunn (author)
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Manoukian, Siranonoush (author)
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Pierotti, Marco A. (author)
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Benitez, Javier (author)
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Caldes, Trinidad (author)
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De La Hoya, Miguel (author)
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Lubinski, Jan (author)
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Arver, Brita (author)
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Simard, Jacques (author)
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Sibille, Catherine (author)
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- Van Asperen, Christi (author)
- Leiden University Medical Centre
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- Meijers-Heijboer, Hanne (author)
- Erasmus University Medical Center
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- Verhoef, Senno (author)
- Netherlands Cancer Institute
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- Vasen, Hans (author)
- Trinity College Dublin
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- Ausems, Margreet (author)
- University Medical Center Utrecht
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- Menko, Fred (author)
- Amsterdam UMC - Vrije Universiteit Amsterdam
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- Gomez-Garcia, Encarna (author)
- Maastricht University Medical Centre
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Cook, Margaret (author)
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Engel, Cassandra (author)
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- Haites, Neva (author)
- Guy's and St Thomas' NHS Foundation Trust
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- Gregory, Helen (author)
- Guy's and St Thomas' NHS Foundation Trust
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- Morrison, Patrick (author)
- Northern Ireland Regional Genetics Service
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- McKeown, Carole (author)
- Birmingham Women’s Hospital Healthcare NHS Trust
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- Donaldson, Alan (author)
- South West Regional Genetics Service
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- Paterson, Joan (author)
- Addenbrooke's Hospital
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- Olsson, H. (creator_code:cre_t)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lunds Melanomstudiegrupp,Forskargrupper vid Lunds universitet,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Melanoma Study Group,Lund University Research Groups
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- Loman, Niklas (creator_code:cre_t)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Bröstcancer-genetik,Institutionen för kliniska vetenskaper, Lund,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Breastcancer-genetics,Department of Clinical Sciences, Lund
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(creator_code:org_t)
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- 2007
- 2007
- English.
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In: Cancer Epidemiology Biomarkers and Prevention. - 1055-9965. ; 16:4, s. 740-746
- Related links:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Background: Early menarche and late menopause are important risk factors for breast cancer, but their effects on breast cancer risk in BRCA1 and BRCA2 carriers are unknown. Methods: We assessed breast cancer risk in a large series of 1,187 BRCA1 and 414 BRCA2 carriers from the International BRCA1/2 Carrier Cohort Study. Rate ratios were estimated using a weighted Cox-regression approach. Results: Breast cancer risk was not significantly related to age at menopause {hazard ratio [HR] for menopause below age 35 years, 0.60 [95% confidence interval (95% CI), 0.25-1.44]; 35 to 40 years, 1.15 [0.65-2.04]; 45 to 54 years, 1.02 [0.65-1.60]; ≥55 years, 1.12 [0.12-5.02], as compared with premenopausal women}. However, there was some suggestion of a reduction in risk after menopause in BRCA2 carriers. There was some evidence of a protective effect of oophorectomy (HR, 0.56; 95% CI, 0.29-1.09) and a significant trend of decreasing risk with increasing time since oophorectomy, but no apparent effect of natural menopause. There was no association between age at menarche and breast cancer risk, nor any apparent association with the estimated total duration of breast mitotic activity. Conclusions: These results are consistent with other observations suggesting a protective effect of oophorectomy, similar in relative effect to that in the general population. The absence of an effect of age at natural menopause is, however, not consistent with findings in the general population and may reflect the different natural history of the disease in carriers.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Chang-Claude, Je ...
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Andrieu, Nadine
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Rookus, Matti
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Brohet, Richard
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Antoniou, Antoni ...
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Peock, Susan
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show more...
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Davidson, Rosema ...
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Izatt, Louise
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Cole, Trevor
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Noguès, Catherin ...
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Luporsi, Elisabe ...
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Huiart, Laetitia
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Hoogerbrugge, Ni ...
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Van Leeuwen, Flo ...
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Osorio, Ana
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Eyfjord, Jorunn
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Radice, Paolo
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Goldgar, David E ...
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Easton, Douglas ...
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Wagner, Teresa
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Korn, Verena
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Gerdes, Anne Mar ...
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Olah, Edith
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Eyford, Jorunn
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Manoukian, Siran ...
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Pierotti, Marco ...
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Benitez, Javier
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Caldes, Trinidad
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De La Hoya, Migu ...
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Lubinski, Jan
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Arver, Brita
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Simard, Jacques
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Sibille, Catheri ...
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Van Asperen, Chr ...
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Meijers-Heijboer ...
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Verhoef, Senno
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Vasen, Hans
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Ausems, Margreet
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Menko, Fred
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Gomez-Garcia, En ...
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Cook, Margaret
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Engel, Cassandra
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Haites, Neva
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Gregory, Helen
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Morrison, Patric ...
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McKeown, Carole
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Donaldson, Alan
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Paterson, Joan
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Olsson, H.
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Loman, Niklas
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Cancer Epidemiol ...
- By the university
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Lund University