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  • Chang-Claude, JennyGerman Cancer Research Centre (author)

Age at menarche and menopause and breast cancer risk in the International BRCA1/2 Carrier Cohort Study

  • Article/chapterEnglish2007

Publisher, publication year, extent ...

  • 2007

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:860d1822-96f0-46f6-ad29-e64a6b82c915
  • https://lup.lub.lu.se/record/860d1822-96f0-46f6-ad29-e64a6b82c915URI
  • https://doi.org/10.1158/1055-9965.EPI-06-0829DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Background: Early menarche and late menopause are important risk factors for breast cancer, but their effects on breast cancer risk in BRCA1 and BRCA2 carriers are unknown. Methods: We assessed breast cancer risk in a large series of 1,187 BRCA1 and 414 BRCA2 carriers from the International BRCA1/2 Carrier Cohort Study. Rate ratios were estimated using a weighted Cox-regression approach. Results: Breast cancer risk was not significantly related to age at menopause {hazard ratio [HR] for menopause below age 35 years, 0.60 [95% confidence interval (95% CI), 0.25-1.44]; 35 to 40 years, 1.15 [0.65-2.04]; 45 to 54 years, 1.02 [0.65-1.60]; ≥55 years, 1.12 [0.12-5.02], as compared with premenopausal women}. However, there was some suggestion of a reduction in risk after menopause in BRCA2 carriers. There was some evidence of a protective effect of oophorectomy (HR, 0.56; 95% CI, 0.29-1.09) and a significant trend of decreasing risk with increasing time since oophorectomy, but no apparent effect of natural menopause. There was no association between age at menarche and breast cancer risk, nor any apparent association with the estimated total duration of breast mitotic activity. Conclusions: These results are consistent with other observations suggesting a protective effect of oophorectomy, similar in relative effect to that in the general population. The absence of an effect of age at natural menopause is, however, not consistent with findings in the general population and may reflect the different natural history of the disease in carriers.

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  • Andrieu, NadineInstitut Gustave Roussy,Curie Institute, Paris (author)
  • Rookus, MattiNetherlands Cancer Institute (author)
  • Brohet, RichardNetherlands Cancer Institute (author)
  • Antoniou, Antonis C.University of Cambridge (author)
  • Peock, SusanUniversity of Cambridge (author)
  • Davidson, RosemarieRoyal Hospital for Sick Children, Glasgow,Royal Marsden Hospital, London (author)
  • Izatt, LouiseGuy's and St Thomas' NHS Foundation Trust (author)
  • Cole, TrevorBirmingham Women’s Hospital Healthcare NHS Trust (author)
  • Noguès, Catherine (author)
  • Luporsi, ElisabethInstitute Cancer De Lorraine - Alexis Vautrin (author)
  • Huiart, LaetitiaInstitut Paoli-Calmettes (author)
  • Hoogerbrugge, NicolineRadboud University Nijmegen,Radboud University Medical Center (author)
  • Van Leeuwen, Flora E.Netherlands Cancer Institute (author)
  • Osorio, AnaSpanish National Cancer Research Center (CNIO) (author)
  • Eyfjord, JorunnIcelandic Cancer Society (author)
  • Radice, PaoloIstituto Nazionale dei Tumori (author)
  • Goldgar, David E. (author)
  • Easton, Douglas F.University of Cambridge (author)
  • Wagner, Teresa (author)
  • Korn, Verena (author)
  • Gerdes, Anne Marie (author)
  • Olah, Edith (author)
  • Eyford, Jorunn (author)
  • Manoukian, Siranonoush (author)
  • Pierotti, Marco A. (author)
  • Benitez, Javier (author)
  • Caldes, Trinidad (author)
  • De La Hoya, Miguel (author)
  • Lubinski, Jan (author)
  • Arver, Brita (author)
  • Simard, Jacques (author)
  • Sibille, Catherine (author)
  • Van Asperen, ChristiLeiden University Medical Centre (author)
  • Meijers-Heijboer, HanneErasmus University Medical Center (author)
  • Verhoef, SennoNetherlands Cancer Institute (author)
  • Vasen, HansTrinity College Dublin (author)
  • Ausems, MargreetUniversity Medical Center Utrecht (author)
  • Menko, FredAmsterdam UMC - Vrije Universiteit Amsterdam (author)
  • Gomez-Garcia, EncarnaMaastricht University Medical Centre (author)
  • Cook, Margaret (author)
  • Engel, Cassandra (author)
  • Haites, NevaGuy's and St Thomas' NHS Foundation Trust (author)
  • Gregory, HelenGuy's and St Thomas' NHS Foundation Trust (author)
  • Morrison, PatrickNorthern Ireland Regional Genetics Service (author)
  • McKeown, CaroleBirmingham Women’s Hospital Healthcare NHS Trust (author)
  • Donaldson, AlanSouth West Regional Genetics Service (author)
  • Paterson, JoanAddenbrooke's Hospital (author)
  • Olsson, H.Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lunds Melanomstudiegrupp,Forskargrupper vid Lunds universitet,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Melanoma Study Group,Lund University Research Groups(Swepub:lu)onk-hol (creator_code:cre_t)
  • Loman, NiklasLund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Bröstcancer-genetik,Institutionen för kliniska vetenskaper, Lund,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Breastcancer-genetics,Department of Clinical Sciences, Lund(Swepub:lu)onk-nlo (creator_code:cre_t)
  • German Cancer Research CentreInstitut Gustave Roussy (creator_code:org_t)
  • BRCA1 and BRCA2 Cohort Consortium

Related titles

  • In:Cancer Epidemiology Biomarkers and Prevention16:4, s. 740-7461055-9965

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