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Residual beta-cell ...
Residual beta-cell function in diabetes children followed and diagnosed in the TEDDY study compared to community controls
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- Steck, Andrea K (author)
- University of Colorado
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- Larsson, Helena Elding (author)
- Lund University,Lunds universitet,Pediatrisk endokrinologi,Forskargrupper vid Lunds universitet,Neonatalogi,Paediatric Endocrinology,Lund University Research Groups,Neonatology,Skåne University Hospital
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- Liu, Xiang (author)
- University of South Florida
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- Veijola, Riitta (author)
- University of Oulu
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- Toppari, Jorma (author)
- Turku University Hospital
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- Hagopian, William A. (author)
- Pacific Northwest Research Institute
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- Haller, Michael J. (author)
- University of Florida
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- Ahmed, Simi (author)
- Juvenile Diabetes Research Foundation
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- Akolkar, Beena (author)
- National Institute of Diabetes and Digestive and Kidney Diseases
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- Lernmark, Åke (author)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups,Skåne University Hospital
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- Rewers, Marian J. (author)
- University of Colorado
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- Krischer, Jeffrey P (author)
- University of South Florida
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(creator_code:org_t)
- 2017-01-27
- 2017
- English.
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In: Pediatric Diabetes. - : Hindawi Limited. - 1399-543X. ; 18:8, s. 794-802
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http://dx.doi.org/10...
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Abstract
Subject headings
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- Objective: To explore whether children diagnosed with type 1 diabetes during islet autoantibody surveillance through The Environmental Determinants of Diabetes in the Young (TEDDY) study retain greater islet function than children diagnosed through the community. Methods: TEDDY children identified at birth with high-risk human leukocyte antigen and followed every 3months until diabetes diagnosis were compared to age-matched children diagnosed with diabetes in the community. Both participated in long-term follow up after diagnosis. Hemoglobin A1c (HbA1c) and mixed meal tolerance test were performed within 1month of diabetes onset, then at 3, 6, and 12months, and biannually thereafter. Results: Comparison of 43 TEDDY and 43 paired control children showed that TEDDY children often had no symptoms (58%) at diagnosis and none had diabetic ketoacidosis (DKA) compared with 98% with diabetes symptoms and 14% DKA in the controls (P<0.001 and P=0.03, respectively). At diagnosis, mean HbA1c was lower in TEDDY (6.8%, 51mmol/mol) than control (10.5%, 91mmol/mol) children (P<0.0001). TEDDY children had significantly higher area under the curve and peak C-peptide values than the community controls throughout the first year postdiagnosis. Total insulin dose and insulin dose-adjusted A1c were lower throughout the first year postdiagnosis for TEDDY compared with control children. Conclusions: Higher C-peptide levels in TEDDY vs community-diagnosed children persist for at least 12months following diabetes onset and appear to represent a shift in the disease process of about 6months. Symptom-free diagnosis, reduction of DKA, and the potential for immune intervention with increased baseline C-peptide may portend additional long-term benefits of early diagnosis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
Keyword
- HbA1c
- Pediatric diabetes
- Preservation of C-peptide
- Prospective study
- Type 1 diabetes
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Steck, Andrea K
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Larsson, Helena ...
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Liu, Xiang
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Veijola, Riitta
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Toppari, Jorma
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Hagopian, Willia ...
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show more...
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Haller, Michael ...
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Ahmed, Simi
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Akolkar, Beena
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Lernmark, Åke
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Rewers, Marian J ...
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Krischer, Jeffre ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Pediatrics
- Articles in the publication
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Pediatric Diabet ...
- By the university
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Lund University