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Immunoglobulin germ...
Immunoglobulin germline gene polymorphisms influence the function of SARS-CoV-2 neutralizing antibodies
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- Pushparaj, Pradeepa (author)
- Karolinska Institutet,Karolinska Institute
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- Nicoletto, Andrea (author)
- Karolinska Institutet,Karolinska Institute
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- Sheward, Daniel J. (author)
- Karolinska Institutet,Karolinska Institute
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- Das, Hrishikesh (author)
- Karolinska Institutet,Karolinska Institute
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- Castro Dopico, Xaquin (author)
- Karolinska Institutet,Karolinska Institute
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- Perez Vidakovics, Laura (author)
- Karolinska Institute
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- Hanke, Leo (author)
- Karolinska Institutet,Karolinska Institute
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- Chernyshev, Mark (author)
- Karolinska Institutet,Karolinska Institute
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- Narang, Sanjana (author)
- Karolinska Institutet,Karolinska Institute
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- Kim, Sungyong (author)
- Karolinska Institute
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- Fischbach, Julian (author)
- Karolinska Institute
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- Ekström, Simon (author)
- Lund University,Lunds universitet,Avdelningen för Biomedicinsk teknik,Institutionen för biomedicinsk teknik,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Biomedical Engineering,Departments at LTH,Faculty of Engineering, LTH
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- McInerney, Gerald (author)
- Karolinska Institutet,Karolinska Institute
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- Hällberg, B. Martin (author)
- Karolinska Institutet,Karolinska Institute
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- Murrell, Ben (author)
- Karolinska Institutet,Karolinska Institute
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- Corcoran, Martin (author)
- Karolinska Institutet,Karolinska Institute
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- Karlsson Hedestam, Gunilla B. (author)
- Karolinska Institutet,Karolinska Institute
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(creator_code:org_t)
- Elsevier BV, 2023
- 2023
- English.
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In: Immunity. - : Elsevier BV. - 1074-7613 .- 1097-4180. ; 56:1, s. 7-206
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Abstract
Subject headings
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- The human immunoglobulin heavy-chain (IGH) locus is exceptionally polymorphic, with high levels of allelic and structural variation. Thus, germline IGH genotypes are personal, which may influence responses to infection and vaccination. For an improved understanding of inter-individual differences in antibody responses, we isolated SARS-CoV-2 spike-specific monoclonal antibodies from convalescent health care workers, focusing on the IGHV1-69 gene, which has the highest level of allelic variation of all IGHV genes. The IGHV1-69∗20-using CAB-I47 antibody and two similar antibodies isolated from an independent donor were critically dependent on allele usage. Neutralization was retained when reverting the V region to the germline IGHV1-69∗20 allele but lost when reverting to other IGHV1-69 alleles. Structural data confirmed that two germline-encoded polymorphisms, R50 and F55, in the IGHV1-69 gene were required for high-affinity receptor-binding domain interaction. These results demonstrate that polymorphisms in IGH genes can influence the function of SARS-CoV-2 neutralizing antibodies.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Keyword
- copy-number variation
- immunoglobulin allelic diversity
- neutralizing antibody
- SARS-CoV-2
- single-nucleotide polymorphism
Publication and Content Type
- art (subject category)
- ref (subject category)
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Immunity
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- By the author/editor
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Pushparaj, Prade ...
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Nicoletto, Andre ...
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Sheward, Daniel ...
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Das, Hrishikesh
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Castro Dopico, X ...
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Perez Vidakovics ...
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show more...
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Hanke, Leo
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Chernyshev, Mark
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Narang, Sanjana
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Kim, Sungyong
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Fischbach, Julia ...
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Ekström, Simon
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McInerney, Geral ...
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Hällberg, B. Mar ...
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Murrell, Ben
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Corcoran, Martin
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Karlsson Hedesta ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Immunology in th ...
- Articles in the publication
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Immunity
- By the university
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Lund University
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Karolinska Institutet