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Risk of subsequent ...
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Heymer, Emma J.University of Birmingham
(author)
Risk of subsequent gliomas and meningiomas among 69,460 5-year survivors of childhood and adolescent cancer in Europe : the PanCareSurFup study
- Article/chapterEnglish2024
Publisher, publication year, extent ...
Numbers
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LIBRIS-ID:oai:lup.lub.lu.se:87322128-6969-4e7b-8cb5-7e49bf0c6b92
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https://lup.lub.lu.se/record/87322128-6969-4e7b-8cb5-7e49bf0c6b92URI
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https://doi.org/10.1038/s41416-024-02577-yDOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:154785539URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Background: Childhood cancer survivors are at risk of subsequent gliomas and meningiomas, but the risks beyond age 40 years are uncertain. We quantified these risks in the largest ever cohort. Methods: Using data from 69,460 5-year childhood cancer survivors (diagnosed 1940–2008), across Europe, standardized incidence ratios (SIRs) and cumulative incidence were calculated. Results: In total, 279 glioma and 761 meningioma were identified. CNS tumour (SIR: 16.2, 95% CI: 13.7, 19.2) and leukaemia (SIR: 11.2, 95% CI: 8.8, 14.2) survivors were at greatest risk of glioma. The SIR for CNS tumour survivors was still 4.3-fold after age 50 (95% CI: 1.9, 9.6), and for leukaemia survivors still 10.2-fold after age 40 (95% CI: 4.9, 21.4). Following cranial radiotherapy (CRT), the cumulative incidence of a glioma in CNS tumour survivors was 2.7%, 3.7% and 5.0% by ages 40, 50 and 60, respectively, whilst for leukaemia this was 1.2% and 1.7% by ages 40 and 50. The cumulative incidence of a meningioma after CRT in CNS tumour survivors doubled from 5.9% to 12.5% between ages 40 and 60, and in leukaemia survivors increased from 5.8% to 10.2% between ages 40 and 50. Discussion: Clinicians following up survivors should be aware that the substantial risks of meningioma and glioma following CRT are sustained beyond age 40 and be vigilant for symptoms.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Hawkins, Michael M.University of Birmingham
(author)
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Winter, David L.University of Birmingham
(author)
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Teepen, Jop C.Princess Maxima Center for Pediatric Oncology/Hematology
(author)
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Sunguc, CerenUniversity of Birmingham
(author)
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Ronckers, Cécile M.Johannes-Gutenberg University Mainz,Princess Maxima Center for Pediatric Oncology/Hematology
(author)
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Allodji, Rodrigue S.Centre for Research in Epidemiology and Population Health (CESP)
(author)
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Alessi, DanielaUniversity of Turin
(author)
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Sugden, ElaineUniversity of Birmingham
(author)
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Belle, Fabiën N.University of Bern,University of Lausanne
(author)
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Bagnasco, FrancescaGaslini Children's Hospital
(author)
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Byrne, JulianneBoyne Research Institute
(author)
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Bárdi, EditSt. Anna Children's Hospital,Kepler University Hospital Linz
(author)
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Garwicz, StanislawLund University,Lunds universitet,Sena effekter efter barncancerbehandling,Forskargrupper vid Lunds universitet,Late effects after childhood cancer treatment,Lund University Research Groups(Swepub:lu)st6750ga
(author)
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Grabow, DesireeJohannes-Gutenberg University Mainz
(author)
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Jankovic, MomciloUniversity of Milano-Bicocca
(author)
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Kaatsch, PeterJohannes-Gutenberg University Mainz
(author)
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Kaiser, MelanieJohannes-Gutenberg University Mainz
(author)
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Michel, GiselaUniversity of Lucerne
(author)
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Schindera, ChristinaUniversity Children's Hospital, Basel,University of Bern
(author)
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Haddy, NadiaCentre for Research in Epidemiology and Population Health (CESP)
(author)
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Journy, NeigeCentre for Research in Epidemiology and Population Health (CESP)
(author)
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Česen Mazić, MajaUniversity Children's Hospital, Ljubljana
(author)
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Skinner, RoderickUniversity of Newcastle upon Tyne
(author)
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Kok, Judith L.Princess Maxima Center for Pediatric Oncology/Hematology
(author)
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Gunnes, Maria W.Cancer Registry of Norway, Institute of Population-Based Cancer Research,Norwegian Radium Hospital
(author)
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Wiebe, ThomasLund University,Lunds universitet,Sena effekter efter barncancerbehandling,Forskargrupper vid Lunds universitet,Late effects after childhood cancer treatment,Lund University Research Groups(Swepub:lu)pedi-twi
(author)
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Sacerdote, CarlottaUniversity of Turin
(author)
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Maule, Milena M.University of Turin
(author)
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Terenziani, MonicaIstituto Nazionale dei Tumori
(author)
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Jakab, ZsuzsannaSemmelweis University
(author)
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Winther, Jeanette F.Aarhus University Hospital,Danish Cancer Society
(author)
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Lähteenmäki, Päivi M.Turku University Hospital
(author)
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Zadravec Zaletel, LornaInstitute of Oncology, Ljubljana
(author)
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Haupt, RiccardoGaslini Children's Hospital
(author)
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Kuehni, Claudia E.University of Bern,University Children's Hospital Bern
(author)
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Kremer, Leontien C.Academic Medical Center of University of Amsterdam (AMC),Princess Maxima Center for Pediatric Oncology/Hematology
(author)
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de Vathaire, FlorentCentre for Research in Epidemiology and Population Health (CESP)
(author)
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Hjorth, LarsLund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Sena effekter efter barncancerbehandling,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Late effects after childhood cancer treatment,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital(Swepub:lu)pedi-lhj
(author)
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Reulen, Raoul C.University of Birmingham
(author)
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University of BirminghamPrincess Maxima Center for Pediatric Oncology/Hematology
(creator_code:org_t)
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Heymer, Emma J.
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Hawkins, Michael ...
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Winter, David L.
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Teepen, Jop C.
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Sunguc, Ceren
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Ronckers, Cécile ...
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Allodji, Rodrigu ...
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Alessi, Daniela
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Sugden, Elaine
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Belle, Fabiën N.
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Bagnasco, France ...
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Byrne, Julianne
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Bárdi, Edit
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Garwicz, Stanisl ...
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Grabow, Desiree
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Jankovic, Momcil ...
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Kaatsch, Peter
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Kaiser, Melanie
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Michel, Gisela
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Schindera, Chris ...
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Haddy, Nadia
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Journy, Neige
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Česen Mazić, Maj ...
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Skinner, Roderic ...
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Kok, Judith L.
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Gunnes, Maria W.
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Wiebe, Thomas
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Sacerdote, Carlo ...
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Maule, Milena M.
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Terenziani, Moni ...
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Jakab, Zsuzsanna
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Winther, Jeanett ...
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Lähteenmäki, Päi ...
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Zadravec Zaletel ...
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Haupt, Riccardo
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Kuehni, Claudia ...
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Kremer, Leontien ...
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de Vathaire, Flo ...
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Hjorth, Lars
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Reulen, Raoul C.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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British Journal ...
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British journal ...
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Lund University
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Karolinska Institutet