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DNA methylation of ...
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Dayeh, TasnimLund University,Lunds universitet,Diabetes - epigenetik,Forskargrupper vid Lunds universitet,Diabetes - Epigenetics,Lund University Research Groups
(författare)
DNA methylation of loci within ABCG1 and PHOSPHO1 in blood DNA is associated with future type 2 diabetes risk
- Artikel/kapitelEngelska2016
Förlag, utgivningsår, omfång ...
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2016-06-09
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Informa UK Limited,2016
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7 s.
Nummerbeteckningar
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LIBRIS-ID:oai:lup.lub.lu.se:87be88fb-5546-421c-b3d0-c3ab1716ee0c
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https://lup.lub.lu.se/record/87be88fb-5546-421c-b3d0-c3ab1716ee0cURI
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https://doi.org/10.1080/15592294.2016.1178418DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
Anmärkningar
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Identification of subjects with a high risk of developing type 2 diabetes (T2D) is fundamental for prevention of the disease. Consequently, it is essential to search for new biomarkers that can improve the prediction of T2D. The aim of this study was to examine whether 5 DNA methylation loci in blood DNA (ABCG1, PHOSPHO1, SOCS3, SREBF1, and TXNIP), recently reported to be associated with T2D, might predict future T2D in subjects from the Botnia prospective study. We also tested if these CpG sites exhibit altered DNA methylation in human pancreatic islets, liver, adipose tissue, and skeletal muscle from diabetic vs. non-diabetic subjects. DNA methylation at the ABCG1 locus cg06500161 in blood DNA was associated with an increased risk for future T2D (OR = 1.09, 95% CI = 1.02–1.16, P-value = 0.007, Q-value = 0.018), while DNA methylation at the PHOSPHO1 locus cg02650017 in blood DNA was associated with a decreased risk for future T2D (OR = 0.85, 95% CI = 0.75–0.95, P-value = 0.006, Q-value = 0.018) after adjustment for age, gender, fasting glucose, and family relation. Furthermore, the level of DNA methylation at the ABCG1 locus cg06500161 in blood DNA correlated positively with BMI, HbA1c, fasting insulin, and triglyceride levels, and was increased in adipose tissue and blood from the diabetic twin among monozygotic twin pairs discordant for T2D. DNA methylation at the PHOSPHO1 locus cg02650017 in blood correlated positively with HDL levels, and was decreased in skeletal muscle from diabetic vs. non-diabetic monozygotic twins. DNA methylation of cg18181703 (SOCS3), cg11024682 (SREBF1), and cg19693031 (TXNIP) was not associated with future T2D risk in subjects from the Botnia prospective study.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Tuomi, TiinamaijaUniversity of Helsinki,Helsinki University Central Hospital,Folkhälsan Research Center(Swepub:lu)ti8736tu
(författare)
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Almgren, PeterLund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine(Swepub:lu)endo-pal
(författare)
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Perfilyev, AlexanderLund University,Lunds universitet,Diabetes - epigenetik,Forskargrupper vid Lunds universitet,Diabetes - Epigenetics,Lund University Research Groups(Swepub:lu)med-apy
(författare)
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Jansson, Per AndersSahlgrenska University Hospital
(författare)
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de Mello, Vanessa D.University of Eastern Finland
(författare)
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Pihlajamäki, JussiUniversity of Eastern Finland,Kuopio University Hospital
(författare)
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Vaag, AllanCopenhagen University Hospital(Swepub:lu)med-ava
(författare)
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Groop, LeifLund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine(Swepub:lu)endo-lgr
(författare)
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Nilsson, EmmaLund University,Lunds universitet,Diabetes - epigenetik,Forskargrupper vid Lunds universitet,Diabetes - Epigenetics,Lund University Research Groups(Swepub:lu)med-en0
(författare)
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Ling, CharlotteLund University,Lunds universitet,Diabetes - epigenetik,Forskargrupper vid Lunds universitet,Diabetes - Epigenetics,Lund University Research Groups(Swepub:lu)endo-cl0
(författare)
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Diabetes - epigenetikForskargrupper vid Lunds universitet
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Epigenetics: Informa UK Limited11:7, s. 482-4881559-22941559-2308
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Dayeh, Tasnim
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Tuomi, Tiinamaij ...
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Almgren, Peter
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Perfilyev, Alexa ...
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Jansson, Per And ...
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de Mello, Vaness ...
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Pihlajamäki, Jus ...
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Vaag, Allan
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Groop, Leif
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Nilsson, Emma
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Ling, Charlotte
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Epigenetics
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