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Homozygous deletion...
Homozygous deletions of cadherin genes in chondrosarcoma-an array comparative genomic hybridization study
- Article/chapterEnglish2012
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Numbers
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LIBRIS-ID:oai:lup.lub.lu.se:87cbf864-323a-4eba-85ea-2fe2f14bb40d
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https://lup.lub.lu.se/record/3373237URI
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https://doi.org/10.1016/j.cancergen.2012.09.007DOI
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Chondrosarcoma is a malignant bone tumor that is often resistant to chemotherapy and radiotherapy. We applied high resolution oligonucleotide array comparative genomic hybridization to 46 tumor specimens from 44 patients with chondrosarcoma and identified several genes with potential importance for the development of chondrosarcoma. Several homozygous deletions were detected. The tumor suppressor genes CDKN2A and MTAP were each homozygously deleted in four of the cases, and the RB1 gene was homozygously deleted in one. Two homozygous deletions of MTAP did not affect CDKN2A. Deletions were also found to affect genes of the cadherin family, including CDH4 and CDH7, each of which had a targeted homozygous loss in one case, and CDH19, which had a targeted homozygous loss in two cases. Loss of the EXT1 and EXT2 genes was uncommon; EXT1 was homozygously deleted in none and EXT2 in two of the cases, and large heterozygous losses including EXT1 and/or EXT2 were seen in three cases. Targeted gains and amplifications affected the MYC, E2F3, CDK6, PDGFRA, KIT, and PDGFD genes in one case each. The data indicate that chondrosarcomas develop through a combination of genomic imbalances that often affect the RB1 signaling pathway. The inactivation of cadherin genes may also be critical in the pathogenesis of the tumor.
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Scheinin, Ilari
(author)
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Lahti, Leo
(author)
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Savola, Suvi
(author)
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Mertens, FredrikLund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)kgen-fme
(author)
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Hollmen, Jaakko
(author)
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Bohling, Tom
(author)
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Kivioja, Aarne
(author)
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Hansén Nord, KarolinLund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)klin-kha
(author)
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Knuutila, Sakari
(author)
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Avdelningen för klinisk genetikInstitutionen för laboratoriemedicin
(creator_code:org_t)
Related titles
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In:Cancer Genetics: Elsevier BV205:11, s. 588-5932210-7762
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Niini, Tarja
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Scheinin, Ilari
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Lahti, Leo
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Savola, Suvi
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Mertens, Fredrik
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Hollmen, Jaakko
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Bohling, Tom
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Kivioja, Aarne
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Hansén Nord, Kar ...
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Knuutila, Sakari
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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Cancer Genetics
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Lund University