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High-Density Lipoprotein function is modulated by the SARS-CoV-2 spike protein in a lipid-type dependent manner

Correa, Yubexi (författare)
Malmö universitet,Malmö University,Biofilms Research Center for Biointerfaces,Institutionen för biomedicinsk vetenskap (BMV)
Del Giudice, Rita (författare)
Malmö universitet,Malmö University,Biofilms Research Center for Biointerfaces,Institutionen för biomedicinsk vetenskap (BMV)
Waldie, Sarah (författare)
Malmö universitet,Malmö University,Life Sciences Group, Institut Laue Langevin, Grenoble F-38042, France; Partnership for Structural Biology, Grenoble F-38042, France,Institutionen för biomedicinsk vetenskap (BMV),Biofilms Research Center for Biointerfaces
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Thépaut, Michel (författare)
University Grenoble Alpes,Univ. Grenoble Alpes, CNRS, CEA, IBS, 71 avenue des Martyrs, F-38000 Grenoble, France
Micciula, Samantha (författare)
Life Sciences Group, Institut Laue Langevin, Grenoble F-38042, France; Large Scale Structures, Institut Laue Langevin (ILL), Grenoble F-38042, France
Gerelli, Yuri (författare)
Marche Polytechnic University, Department of Life and Environmental Sciences, Via Brecce Bianche 12, 60131 Ancona, Italy; CNR-ISC and Department of Physics, Sapienza University of Rome, Piazzale A. Moro 2, Rome, Italy
Moulin, Martine (författare)
Life Sciences Group, Institut Laue Langevin, Grenoble F-38042, France; Partnership for Structural Biology, Grenoble F-38042, France
Delaunay, Clara (författare)
University Grenoble Alpes,Univ. Grenoble Alpes, CNRS, CEA, IBS, 71 avenue des Martyrs, F-38000 Grenoble, France
Fieschi, Franck (författare)
University Grenoble Alpes,Partnership for Structural Biology, Grenoble F-38042, France; Univ. Grenoble Alpes, CNRS, CEA, IBS, 71 avenue des Martyrs, F-38000 Grenoble, France; Institut universitaire de France (IUF), Paris, France
Pichler, Harald (författare)
Austrian Center of Industrial Biotechnology GmbH,Austrian Centre of Industrial Biotechnology, Petersgasse 14, 8010 Graz, Austria; Graz University of Technology, Institute of Molecular Biotechnology, NAWI Graz, BioTechMed Graz, Petersgasse 14, 8010 Graz, Austria
Haertlein, Michael (författare)
Life Sciences Group, Institut Laue Langevin, Grenoble F-38042, France; Partnership for Structural Biology, Grenoble F-38042, France
Forsyth, V. Trevor (författare)
Lund University,Lunds universitet,LINXS - Institute of advanced Neutron and X-ray Science,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Molekylär Biofysik,Forskargrupper vid Lunds universitet,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH,Molecular Biophysics,Lund University Research Groups,LU Profile Area: Proactive Ageing,Lund University Profile areas,Life Sciences Group, Institut Laue Langevin, Grenoble F-38042, France; Partnership for Structural Biology, Grenoble F-38042, France; Faculty of Medicine, Lund University, 22184 Lund, Sweden; LINXS Institute for Advanced Neutron and X-ray Science, Scheelevagen 19, 22370 Lund, Sweden
Le Brun, Anton (författare)
National Deuteration Facility, Australian Nuclear Science and Technology Organization (ANSTO), New Illawarra Road, Lucas Heights, NSW 2234, Australia
Moir, Michael (författare)
National Deuteration Facility, Australian Nuclear Science and Technology Organization (ANSTO), New Illawarra Road, Lucas Heights, NSW 2234, Australia
Russell, Robert A. (författare)
National Deuteration Facility, Australian Nuclear Science and Technology Organization (ANSTO), New Illawarra Road, Lucas Heights, NSW 2234, Australia
Darwish, Tamim (författare)
National Deuteration Facility, Australian Nuclear Science and Technology Organization (ANSTO), New Illawarra Road, Lucas Heights, NSW 2234, Australia
Brinck, Jonas (författare)
Karolinska Institutet,Karolinska Institute,Karolinska Institute, Stockholm, Sweden
Wodaje, Tigist (författare)
Karolinska Institutet,Karolinska Institute,Karolinska Institute, Stockholm, Sweden
Jansen, Martin (författare)
Institute of Clinical Chemistry and Laboratory Medicine, Medical Centre, University of Freiburg, Freiburg Im Breisgau, Germany
Martín, César (författare)
CSIC Spanish National Research Council,Department of Molecular Biophysics, Biofisika Institute (University of Basque Country and Consejo Superior de Investigaciones Científicas (UPV/EHU, CSIC)), 48940 Leioa, Spain
Roosen - Runge, Felix (författare)
Malmö universitet,Malmö University,Institutionen för biomedicinsk vetenskap (BMV),Biofilms Research Center for Biointerfaces
Cárdenas, Marité (författare)
Malmö universitet,Malmö University,CSIC Spanish National Research Council,Department of Molecular Biophysics, Biofisika Institute (University of Basque Country and Consejo Superior de Investigaciones Científicas (UPV/EHU, CSIC)), 48940 Leioa, Spain; School of Biological Sciences, Nanyang Technological University, Singapore; IKERBASQUE, Basque Foundation for Science, Bilbao, Spain,Basque Foundation for Science,Institutionen för biomedicinsk vetenskap (BMV),Biofilms Research Center for Biointerfaces
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 (creator_code:org_t)
Elsevier, 2023
2023
Engelska 12 s.
Ingår i: Journal of Colloid and Interface Science. - : Elsevier. - 0021-9797 .- 1095-7103. ; 645, s. 627-638
Relaterad länk:
http://dx.doi.org/10... (free)
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https://doi.org/10.1...
https://mau.diva-por... (primary) (Raw object)
https://lup.lub.lu.s...
https://doi.org/10.1...
https://urn.kb.se/re...
http://kipublication...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • There is a close relationship between the SARS-CoV-2 virus and lipoproteins, in particular high-density lipoprotein (HDL). The severity of the coronavirus disease 2019 (COVID-19) is inversely correlated with HDL plasma levels. It is known that the SARS-CoV-2 spike (S) protein binds the HDL particle, probably depleting it of lipids and altering HDL function. Based on neutron reflectometry (NR) and the ability of HDL to efflux cholesterol from macrophages, we confirm these observations and further identify the preference of the S protein for specific lipids and the consequent effects on HDL function on lipid exchange ability. Moreover, the effect of the S protein on HDL function differs depending on the individuals lipid serum profile. Contrasting trends were observed for individuals presenting low triglycerides/high cholesterol serum levels (LTHC) compared to high triglycerides/high cholesterol (HTHC) or low triglycerides/low cholesterol serum levels (LTLC). Collectively, these results suggest that the S protein interacts with the HDL particle and, depending on the lipid profile of the infected individual, it impairs its function during COVID-19 infection, causing an imbalance in lipid metabolism.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Läkemedelskemi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Medicinal Chemistry (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Microbiology in the medical area (hsv//eng)

Nyckelord

Cholesterol efflux capacity
COVID-19
Deuterated cholesterol
HDL
Lipid metabolism
Lipids
Neutron reflection
SARS-CoV-2 spike protein
COVID-19

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