HEARTBiT : A Transcriptomic Signature for Excluding Acute Cellular Rejection in Adult Heart Allograft Patients

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HEARTBiT : A Transcriptomic Signature for Excluding Acute Cellular Rejection in Adult Heart Allograft Patients

Shannon, Casey P. (author): PROOF Centre for Excellence

Hollander, Zsuzsanna (author): PROOF Centre for Excellence

Dai, Darlene L.Y. (author): PROOF Centre for Excellence

Chen, Virginia (author): PROOF Centre for Excellence

Assadian, Sara (author): PROOF Centre for Excellence

Lam, Karen K. (author): PROOF Centre for Excellence,University of British Columbia

McManus, Janet E. (author): PROOF Centre for Excellence

Zarzycki, Marek (author): PROOF Centre for Excellence,University of British Columbia

Kim, Young Woong (author): University of British Columbia

Kim, Ji Young V. (author): PROOF Centre for Excellence,University of British Columbia

Balshaw, Robert (author): PROOF Centre for Excellence,University of British Columbia

Gidlöf, Olof (author): Lund University,Lunds universitet,Cardiovascular Epigenetics,Forskargrupper vid Lunds universitet,Lund University Research Groups,Skåne University Hospital

Öhman, Jenny (author): Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital

Smith, J. Gustav (author): Lund University,Lunds universitet,Cardiovascular Epigenetics,Forskargrupper vid Lunds universitet,Lund University Research Groups,Skåne University Hospital

Toma, Mustafa (author): University of British Columbia

Ignaszewski, Andrew (author): University of British Columbia

Davies, Ross A. (author): University of Ottawa

Delgado, Diego (author): University of Toronto

Haddad, Haissam (author): University of Saskatchewan

Isaac, Debra (author): University of Alberta

Kim, Daniel (author): University of Alberta

Mui, Alice (author): University of British Columbia

Rajda, Miroslaw (author): Dalhousie University

West, Lori (author): University of Alberta

White, Michel (author): Montreal Heart Institute

Zieroth, Shelley (author): University of Manitoba

Tebbutt, Scott J. (author): University of British Columbia,PROOF Centre for Excellence

Keown, Paul A. (author): University of British Columbia

McMaster, W. Robert (author): University of British Columbia

Ng, Raymond T. (author): PROOF Centre for Excellence,University of British Columbia

McManus, Bruce M. (author): University of British Columbia,PROOF Centre for Excellence

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(creator_code:org_t)

Elsevier BV, 2020
2020
English 11 s.
In: Canadian Journal of Cardiology. - : Elsevier BV. - 0828-282X. ; 36:8, s. 1217-1227

Related links:: http://dx.doi.org/10...; show more...; https://lup.lub.lu.s...; https://doi.org/10.1...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

Background: Nine mRNA transcripts associated with acute cellular rejection (ACR) in previous microarray studies were ported to the clinically amenable NanoString nCounter platform. Here we report the diagnostic performance of the resulting blood test to exclude ACR in heart allograft recipients: HEARTBiT. Methods: Blood samples for transcriptomic profiling were collected during routine post-transplantation monitoring in 8 Canadian transplant centres participating in the Biomarkers in Transplantation initiative, a large (n = 1622) prospective observational study conducted between 2009 and 2014. All adult cardiac transplant patients were invited to participate (median age = 56 [17 to 71]). The reference standard for rejection status was histopathology grading of tissue from endomyocardial biopsy (EMB). All locally graded ISHLT ≥ 2R rejection samples were selected for analysis (n = 36). ISHLT 1R (n = 38) and 0R (n = 86) samples were randomly selected to create a cohort approximately matched for site, age, sex, and days post-transplantation, with a focus on early time points (median days post-transplant = 42 [7 to 506]). Results: ISHLT ≥ 2R rejection was confirmed by EMB in 18 and excluded in 92 samples in the test set. HEARTBiT achieved 47% specificity (95% confidence interval [CI], 36%-57%) given ≥ 90% sensitivity, with a corresponding area under the receiver operating characteristic curve of 0.69 (95% CI, 0.56-0.81). Conclusions: HEARTBiT's diagnostic performance compares favourably to the only currently approved minimally invasive diagnostic test to rule out ACR, AlloMap (CareDx, Brisbane, CA) and may be used to inform care decisions in the first 2 months post-transplantation, when AlloMap is not approved, and most ACR episodes occur.

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cardiac and Card ...

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By the university: Lund University

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HEARTBiT : A Transcriptomic Signature for Excluding Acute Cellular Rejection in Adult Heart Allograft Patients

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