Search: (WFRF:(Klopp Norman)) pers:(Morris Andrew D) pers:(Tuomi Tiinamaija) pers:(Stefansson Kari) >
Genetic fine mappin...
Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci.
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- Gaulton, Kyle J (author)
- Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.;Stanford Univ, Dept Genet, Stanford, CA 94305 USA.
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- Ferreira, Teresa (author)
- Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.
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- Lee, Yeji (author)
- Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA.
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- Raimondo, Anne (author)
- Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England.
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- Mägi, Reedik (author)
- Univ Tartu, Estonian Genome Ctr, EE-50090 Tartu, Estonia.
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- Reschen, Michael E (author)
- Univ Oxford, Nuffield Dept Med, Ctr Cellular & Mol Physiol, Oxford, England.,CNRS, UMR 8199, Inst Biol, Lille, France.;Univ Lille 2, Inst Pasteur, Lille, France.
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- Mahajan, Anubha (author)
- Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.
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- Locke, Adam (author)
- Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA.
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- William Rayner, N (author)
- Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.;Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England.;Wellcome Trust Sanger Inst, Hinxton, England.
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- Robertson, Neil (author)
- Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.;Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England.
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- Scott, Robert A (author)
- Univ Cambridge, Sch Clin Med, Inst Metab Sci, Med Res Council MRC Epidemiol Unit, Cambridge, England.
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- Prokopenko, Inga (author)
- Univ London Imperial Coll Sci Technol & Med, Genom Common Dis, London, England.
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- Scott, Laura J (author)
- Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA.
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- Green, Todd (author)
- Broad Inst Harvard & MIT, Cambridge, MA USA.
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- Sparso, Thomas (author)
- Univ Copenhagen, Fac Hlth & Med Sci, Novo Nordisk Fdn Ctr Basic Metab Res, Copenhagen, Denmark.
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- Thuillier, Dorothee (author)
- European Genom Inst Diabet, Lille Inst Biol, Lille, France.
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- Yengo, Loic (author)
- European Genom Inst Diabet, Lille Inst Biol, Lille, France.
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- Grallert, Harald (author)
- German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Res Unit Mol Epidemiol, Neuherberg, Germany.;German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Epidemiol 2, Neuherberg, Germany.;German Ctr Diabet Res, Neuherberg, Germany.
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- Wahl, Simone (author)
- German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Res Unit Mol Epidemiol, Neuherberg, Germany.;German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Epidemiol 2, Neuherberg, Germany.;German Ctr Diabet Res, Neuherberg, Germany.
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- Frånberg, Mattias (author)
- Stockholms universitet,Numerisk analys och datalogi (NADA),Science for Life Laboratory (SciLifeLab),Karolinska Institutet, Sweden,Karolinska Inst, Dept Med Solna, Atherosclerosis Res Unit, Stockholm, Sweden.;Sci Life Lab, Stockholm, Sweden.;Stockholm Univ, Dept Numer Anal & Comp Sci, S-10691 Stockholm, Sweden.
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- Strawbridge, Rona J (author)
- Karolinska Institutet,Karolinska Inst, Dept Med Solna, Atherosclerosis Res Unit, Stockholm, Sweden.
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- Kestler, Hans (author)
- Fritz Lipmann Inst, Leibniz Inst Age Res, Jena, Germany.;Univ Ulm, Med Syst Biol, D-89069 Ulm, Germany.
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- Chheda, Himanshu (author)
- Finnish Inst Mol Med, Helsinki, Finland.
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- Eisele, Lewin (author)
- Univ Hosp Essen, Inst Med Informat Biometry & Epidemiol, Essen, Germany.
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- Gustafsson, Stefan (author)
- Uppsala universitet,Molekylär epidemiologi
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- Steinthorsdottir, Valgerdur (author)
- deCODE Genet Amgen Inc, Reykjavik, Iceland.
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- Thorleifsson, Gudmar (author)
- deCODE Genet Amgen Inc, Reykjavik, Iceland.
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- Qi, Lu (author)
- Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.;Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.;Brigham & Womens Hosp, Dept Med, Channing Div Network Med, Boston, MA 02115 USA.;Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA.;Tulane Univ, Sch Publ Hlth & Trop Med, Dept Epidemiol, New Orleans, LA USA.
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- Karssen, Lennart C (author)
- Erasmus Univ, Med Ctr, Dept Epidemiol, Rotterdam, Netherlands.
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- van Leeuwen, Elisabeth M (author)
- Erasmus Univ, Med Ctr, Dept Epidemiol, Rotterdam, Netherlands.
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- Willems, Sara M (author)
- Univ Cambridge, Sch Clin Med, Inst Metab Sci, Med Res Council MRC Epidemiol Unit, Cambridge, England.;Erasmus Univ, Med Ctr, Dept Epidemiol, Rotterdam, Netherlands.
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- Li, Man (author)
- Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA.
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- Chen, Han (author)
- Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA.;Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA.
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- Fuchsberger, Christian (author)
- Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA.
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- Kwan, Phoenix (author)
- Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA.
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- Ma, Clement (author)
- Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA.
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- Linderman, Michael (author)
- Icahn Sch Med Mt Sinai, Icahn Inst Genom & Multiscale Biol, New York, NY 10029 USA.,Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.;Broad Inst Harvard & MIT, Cambridge, MA USA.
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- Lu, Yingchang (author)
- Icahn Sch Med Mt Sinai, Genet Obes & Related Metab Traits Program, New York, NY 10029 USA.
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- Thomsen, Soren K (author)
- Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England.
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- Rundle, Jana K (author)
- Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England.
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- Lind, Lars (author)
- Uppsala universitet,Kardiovaskulär epidemiologi,Univ N Carolina, Dept Genet, Chapel Hill, NC USA.,Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.;Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England.;Churchill Hosp, Biomed Res Ctr, Oxford Natl Inst Hlth Res, Oxford OX3 7LJ, England.
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- van de Bunt, Martijn (author)
- Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.;Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England.
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- Chalisey, Anil (author)
- Univ Oxford, Nuffield Dept Med, Ctr Cellular & Mol Physiol, Oxford, England.
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- Kang, Hyun Min (author)
- Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA.
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- Voight, Benjamin F (author)
- Univ Penn, Perelman Sch Med, Dept Pharmacol, Philadelphia, PA 19104 USA.
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- Abecasis, Gonçalo R (author)
- Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA.,Kuopio Res Inst Exercise Med, Kuopio, Finland.;Kuopio Univ Hosp, Dept Clin Physiol & Nucl Med, SF-70210 Kuopio, Finland.
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- Almgren, Peter (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Lund Univ, Scania Univ Hosp, Dept Clin Sci Malmo, Ctr Diabet, Malmo, Sweden.
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- Baldassarre, Damiano (author)
- IRCCS, Ctr Cardiol Monzino, Milan, Italy.;Univ Milan, Dipartimento Sci Farmacol & Biomol, Milan, Italy.
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- Balkau, Beverley (author)
- Karolinska Institutet,Ctr Rech Epidemiol & Sante Populat CESP, INSERM, U1018, Villejuif, France.;Univ Paris 11, UMRS 1018, Villejuif, France.,Broad Inst Harvard & MIT, Cambridge, MA USA.,Landspitali Univ Hosp, Reykjavik, Iceland.,Univ Cambridge, Sch Clin Med, Inst Metab Sci, Med Res Council MRC Epidemiol Unit, Cambridge, England.,Massachusetts Gen Hosp, Gen Med Div, Boston, MA 02114 USA.,Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.;Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.;Brigham & Womens Hosp, Dept Med, Channing Div Network Med, Boston, MA 02115 USA.;Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA.
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- Benediktsson, Rafn (author)
- Univ Iceland, Fac Med, Reykjavik, Iceland.;Landspitali Univ Hosp, Reykjavik, Iceland.
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- Blüher, Matthias (author)
- Univ Leipzig, Integrated Treatment & Res IFB Ctr Adipos Dis, D-04109 Leipzig, Germany.;Univ Leipzig, Dept Med, D-04109 Leipzig, Germany.
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- Boeing, Heiner (author)
- German Inst Human Nutr, Potsdam, Germany.
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- Bonnycastle, Lori L (author)
- NHGRI, US NIH, Bethesda, MD 20892 USA.
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- Bottinger, Erwin P (author)
- Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA.
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- Burtt, Noël P (author)
- Broad Inst Harvard & MIT, Cambridge, MA USA.
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- Carey, Jason (author)
- Broad Inst Harvard & MIT, Cambridge, MA USA.
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- Charpentier, Guillaume (author)
- Corbeil Essonnes Hosp, Endocrinol Diabetol Unit, Corbeil Essonnes, France.
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- Chines, Peter S (author)
- NHGRI, US NIH, Bethesda, MD 20892 USA.,Lund Univ, Scania Univ Hosp, Dept Clin Sci Malmo, Ctr Diabet, Malmo, Sweden.
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- Cornelis, Marilyn C (author)
- Northwestern Univ, Feinberg Sch Med, Dept Prevent Med, Chicago, IL 60611 USA.
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- Couper, David J (author)
- Univ N Carolina, Dept Biostat, Collaborat Studies Coordinating Ctr, Chapel Hill, NC USA.
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- Crenshaw, Andrew T (author)
- Broad Inst Harvard & MIT, Cambridge, MA USA.,Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA.;Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England.;Finnish Inst Mol Med, Helsinki, Finland.;Folkhalsan Res Ctr, Helsinki, Finland.;Helsinki Univ Hosp, Abdominal Ctr, Dept Endocrinol, Helsinki, Finland.;Univ Helsinki, Res Program Diabet & Obes, Helsinki, Finland.
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- van Dam, Rob M (author)
- Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.;Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore 117548, Singapore.
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- Doney, Alex S F (author)
- Univ Dundee, Ninewells Hosp, Biomed Res Inst, Ctr Diabet Res, Dundee, Scotland.;Univ Dundee, Ninewells Hosp, Biomed Res Inst, Pharmacogen Ctr, Dundee, Scotland.
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- Dorkhan, Mozhgan (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Lund Univ, Ctr Diabet, Dept Clin Sci Malmo, Novo Nordisk Scandinavia, Malmo, Sweden.
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- Edkins, Sarah (author)
- Wellcome Trust Sanger Inst, Hinxton, England.
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- Eriksson, Johan G (author)
- Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Helsinki, Finland.;Univ Helsinki, Dept Gen Practice & Primary Hlth Care, Helsinki, Finland.;Univ Helsinki, Cent Hosp, Unit Gen Practice, Helsinki, Finland.;Folkhalsan Res Ctr, Helsinki, Finland.
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- Esko, Tonu (author)
- Univ Tartu, Estonian Genome Ctr, EE-50090 Tartu, Estonia.;Childrens Hosp, Div Endocrinol, Boston, MA 02115 USA.;Broad Inst Harvard & MIT, Program Med & Populat Genet, Cambridge, MA USA.
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- Eury, Elodie (author)
- UCL, Inst Cardiovasc Sci, British Heart Fdn BHF Labs, Cardiovasc Genet, London, England.,Steno Diabet Ctr, DK-2820 Gentofte, Denmark.,Finnish Diabet Assoc, Tampere, Finland.;Pirkanmaa Dist Hosp, Tampere, Finland.
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- Fadista, Joao (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Lund Univ, Scania Univ Hosp, Dept Clin Sci Malmo, Ctr Diabet, Malmo, Sweden.,Univ Cambridge, Sch Clin Med, Inst Metab Sci, Med Res Council MRC Epidemiol Unit, Cambridge, England.;Icahn Sch Med Mt Sinai, Genet Obes & Related Metab Traits Program, New York, NY 10029 USA.;Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA.;Icahn Sch Med Mt Sinai, Mindich Child Hlth & Dev Inst, New York, NY 10029 USA. Harvard Univ, Sch Med, Dept Med, Boston, MA USA.
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- Flannick, Jason (author)
- Broad Inst Harvard & MIT, Cambridge, MA USA.
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- Fontanillas, Pierre (author)
- Broad Inst Harvard & MIT, Cambridge, MA USA.
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- Fox, Caroline (author)
- NHLBI, Framingham Heart Study, Framingham, MA USA.;Brigham & Womens Hosp, Div Endocrinol & Metab, Boston, MA 02115 USA.;Harvard Univ, Sch Med, Boston, MA USA.
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- Franks, Paul (author)
- Umeå universitet,Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Medicin,Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA; Lund University Diabetes Centre, Department of Clinical Science Malmö, Scania University Hospital, Lund University, Malmö, Sweden; Department of Clinical Sciences, Lund University, Malmö, Sweden.,Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.;Lund Univ, Scania Univ Hosp, Dept Clin Sci Malmo, Ctr Diabet, Malmo, Sweden.;Lund Univ, Dept Clin Sci, Malmo, Sweden.;Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden.
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- Gertow, Karl (author)
- Karolinska Institutet,Karolinska Inst, Dept Med Solna, Atherosclerosis Res Unit, Stockholm, Sweden.,Norwegian Univ Sci & Technol, Dept Publ Hlth & Gen Practice, Nord Trondelag Hlth Study HUNT Res Ctr, Levanger, Norway.;Nord Trondelag Hlth Trust, Levanger Hosp, Dept Internal Med, Levanger, Norway.
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- Gieger, Christian (author)
- German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Res Unit Mol Epidemiol, Neuherberg, Germany.;German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Epidemiol 2, Neuherberg, Germany.
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- Gigante, Bruna (author)
- Karolinska Inst, Inst Environm Med, Div Cardiovasc Epidemiol, S-10401 Stockholm, Sweden.
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- Gottesman, Omri (author)
- Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA.
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Grant, George B (author)
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- Grarup, Niels (author)
- Univ Copenhagen, Fac Hlth & Med Sci, Novo Nordisk Fdn Ctr Basic Metab Res, Copenhagen, Denmark.
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- Groves, Christopher J (author)
- Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England.
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- Hassinen, Maija (author)
- Kuopio Res Inst Exercise Med, Kuopio, Finland.
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- Have, Christian T (author)
- Univ Copenhagen, Fac Hlth & Med Sci, Novo Nordisk Fdn Ctr Basic Metab Res, Copenhagen, Denmark.
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- Herder, Christian (author)
- Univ Dusseldorf, Leibniz Ctr Diabet Res, German Diabet Ctr, Inst Clin Diabetol, Dusseldorf, Germany.;Partner Site Dusseldorf, German Ctr Diabet Res, Dusseldorf, Germany.
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- Holmen, Oddgeir L (author)
- Norwegian Univ Sci & Technol, Dept Publ Hlth & Gen Practice, Nord Trondelag Hlth Study HUNT Res Ctr, Levanger, Norway.
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Hreidarsson, Astradur B (author)
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Humphries, Steve E (author)
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- Hunter, David J (author)
- Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.;Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.;Brigham & Womens Hosp, Dept Med, Channing Div Network Med, Boston, MA 02115 USA.;Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA.;Harvard Univ, Sch Publ Hlth, Program Genet Epidemiol & Stat Genet, Boston, MA 02115 USA.
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- Jackson, Anne U (author)
- Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA.
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- Jonsson, Anna (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Lund Univ, Scania Univ Hosp, Dept Clin Sci Malmo, Ctr Diabet, Malmo, Sweden.
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Jørgensen, Marit E (author)
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- Jørgensen, Torben (author)
- Capital Reg Denmark, Res Ctr Prevent & Hlth, Copenhagen, Denmark.;Univ Copenhagen, Fac Hlth & Med Sci, Copenhagen, Denmark.;Aalborg Univ, Fac Med, Aalborg, Denmark.
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- Kao, Wen-Hong L (author)
- Karolinska Institutet,Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA.
-
- Kerrison, Nicola D (author)
- Univ Cambridge, Sch Clin Med, Inst Metab Sci, Med Res Council MRC Epidemiol Unit, Cambridge, England.
-
- Kinnunen, Leena (author)
- Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Helsinki, Finland.
-
- Klopp, Norman (author)
- German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Res Unit Mol Epidemiol, Neuherberg, Germany.;Hannover Med Sch, Hannover Unified Biobank, Hannover, Germany.
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- Kong, Augustine (author)
- deCODE Genet Amgen Inc, Reykjavik, Iceland.
-
- Kovacs, Peter (author)
- Univ Leipzig, Integrated Treatment & Res IFB Ctr Adipos Dis, D-04109 Leipzig, Germany.;Univ Leipzig, Dept Med, D-04109 Leipzig, Germany.
-
- Kraft, Peter (author)
- Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.;Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA.;Harvard Univ, Sch Publ Hlth, Program Genet Epidemiol & Stat Genet, Boston, MA 02115 USA.
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- Kravic, Jasmina (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Lund Univ, Scania Univ Hosp, Dept Clin Sci Malmo, Ctr Diabet, Malmo, Sweden.
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- Langford, Cordelia (author)
- Wellcome Trust Sanger Inst, Hinxton, England.
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- Leander, Karin (author)
- Karolinska Inst, Inst Environm Med, Div Cardiovasc Epidemiol, S-10401 Stockholm, Sweden.
-
- Liang, Liming (author)
- Karolinska Institutet,Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.
-
- Lichtner, Peter (author)
- German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Human Genet, Neuherberg, Germany.
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Lindgren, Cecilia M (author)
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- Lindholm, Eero (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Lund Univ, Scania Univ Hosp, Dept Clin Sci Malmo, Ctr Diabet, Malmo, Sweden.
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- Linneberg, Allan (author)
- Capital Reg Denmark, Res Ctr Prevent & Hlth, Copenhagen, Denmark.;Rigshosp, Copenhagen Univ Hosp, DK-2100 Copenhagen, Denmark.;Univ Copenhagen, Fac Hlth & Med Sci, Dept Clin Med, Copenhagen, Denmark.
-
- Liu, Ching-Ti (author)
- Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA.
-
- Lobbens, Stéphane (author)
- CNRS, UMR 8199, Inst Biol, Lille, France.;Univ Lille 2, Inst Pasteur, Lille, France.
-
- Luan, Jian'an (author)
- Univ Cambridge, Sch Clin Med, Inst Metab Sci, Med Res Council MRC Epidemiol Unit, Cambridge, England.
-
- Lyssenko, Valeriya (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Lund Univ, Scania Univ Hosp, Dept Clin Sci Malmo, Ctr Diabet, Malmo, Sweden.;Steno Diabet Ctr, DK-2820 Gentofte, Denmark.
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- Männistö, Satu (author)
- Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Helsinki, Finland.
-
- McLeod, Olga (author)
- Karolinska Inst, Dept Med Solna, Atherosclerosis Res Unit, Stockholm, Sweden.
-
- Meyer, Julia (author)
- German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Genet Epidemiol, Neuherberg, Germany.,Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.;Univ Oxford, Dept Stat, Oxford OX1 3TG, England.
-
- Mihailov, Evelin (author)
- Univ Tartu, Estonian Genome Ctr, EE-50090 Tartu, Estonia.
-
- Mirza, Ghazala (author)
- Guys & St Thomas Natl Hlth Serv NHS Fdn Trust, Guys & St Thomas Hosp, Genom Core Facil, Biomed Res Ctr, London, England.
-
- Mühleisen, Thomas W (author)
- Univ Bonn, Inst Human Genet, Bonn, Germany.;Univ Bonn, Life & Brain Ctr, Dept Genom, Bonn, Germany.;Res Ctr Julich, Inst Neurosci & Med INM 1, Julich, Germany.
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- Müller-Nurasyid, Martina (author)
- German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Genet Epidemiol, Neuherberg, Germany.;Univ Munich, Univ Hosp Grosshadern, Dept Med 1, Munich, Germany.;Univ Munich, Chair Genet Epidemiol, Inst Med Informat Biometry & Epidemiol, Neuherberg, Germany.;Partner Site Munich Heart Alliance, DZHK German Ctr Cardiovasc Res, Munich, Germany.
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- Navarro, Carmen (author)
- Inst Murciano Invest Biosanitaria Virgen de la Ar, Murcia Reg Hlth Council, Dept Epidemiol, Murcia, Spain.;CIBERESP, Madrid, Spain.;Univ Murcia, Dept Hlth & Social Sci, Murcia, Spain.
-
- Nöthen, Markus M (author)
- Univ Bonn, Inst Human Genet, Bonn, Germany.;Univ Bonn, Life & Brain Ctr, Dept Genom, Bonn, Germany.
-
- Oskolkov, Nikolay (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Lund Univ, Scania Univ Hosp, Dept Clin Sci Malmo, Ctr Diabet, Malmo, Sweden.
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- Owen, Katharine R (author)
- Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England.;Churchill Hosp, Biomed Res Ctr, Oxford Natl Inst Hlth Res, Oxford OX3 7LJ, England.
-
- Palli, Domenico (author)
- Canc Res & Prevent Inst ISPO, Florence, Italy.
-
- Pechlivanis, Sonali (author)
- Univ Hosp Essen, Inst Med Informat Biometry & Epidemiol, Essen, Germany.
-
- Peltonen, Leena (author)
- Wellcome Trust Sanger Inst, Hinxton, England.;Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Helsinki, Finland.
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Perry, John R B (author)
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Platou, Carl G P (author)
-
- Roden, Michael (author)
- Univ Dusseldorf, Leibniz Ctr Diabet Res, German Diabet Ctr, Inst Clin Diabetol, Dusseldorf, Germany.;Partner Site Dusseldorf, German Ctr Diabet Res, Dusseldorf, Germany.;Univ Hosp Dusseldorf, Dept Endocrinol & Diabetol, Dusseldorf, Germany.
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- Ruderfer, Douglas (author)
- Icahn Sch Med Mt Sinai, Dept Psychiat, Div Psychiat Genom, New York, NY 10029 USA.
-
- Rybin, Denis (author)
- Boston Univ, Data Coordinating Ctr, Boston, MA 02215 USA.
-
- van der Schouw, Yvonne T (author)
- Univ Med Ctr Utrecht, Utrecht, Netherlands.
-
- Sennblad, Bengt (author)
- Karolinska Inst, Dept Med Solna, Atherosclerosis Res Unit, Stockholm, Sweden.;Sci Life Lab, Stockholm, Sweden.
-
- Sigurðsson, Gunnar (author)
- Landspitali Univ Hosp, Reykjavik, Iceland.;Iceland Heart Assoc, Kopavogur, Iceland.
-
- Stančáková, Alena (author)
- Univ Eastern Finland, Dept Med, Kuopio, Finland.;Kuopio Univ Hosp, SF-70210 Kuopio, Finland.
-
- Steinbach, Gerald (author)
- Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.;Univ Ulm, Dept Clin Chem & Cent Lab, D-89069 Ulm, Germany.
-
- Storm, Petter (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
-
- Strauch, Konstantin (author)
- German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Genet Epidemiol, Neuherberg, Germany.;Univ Munich, Chair Genet Epidemiol, Inst Med Informat Biometry & Epidemiol, Neuherberg, Germany.
-
- Stringham, Heather M (author)
- Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA.
-
- Sun, Qi (author)
- Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.;Brigham & Womens Hosp, Dept Med, Channing Div Network Med, Boston, MA 02115 USA.;Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA.
-
- Thorand, Barbara (author)
- German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Epidemiol 2, Neuherberg, Germany.;German Ctr Diabet Res, Neuherberg, Germany.
-
- Tikkanen, Emmi (author)
- Stanford Univ, Dept Genet, Stanford, CA 94305 USA.;Finnish Inst Mol Med, Helsinki, Finland.;Univ Helsinki, Dept Publ Hlth, Hjelt Inst, Helsinki, Finland.
-
- Tonjes, Anke (author)
- Univ Leipzig, Integrated Treatment & Res IFB Ctr Adipos Dis, D-04109 Leipzig, Germany.;Univ Leipzig, Dept Med, D-04109 Leipzig, Germany.
-
- Trakalo, Joseph (author)
- Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.
-
- Tremoli, Elena (author)
- IRCCS, Ctr Cardiol Monzino, Milan, Italy.;Univ Milan, Dipartimento Sci Farmacol & Biomol, Milan, Italy.
-
- Tuomi, Tiinamaija (author)
- Univ Exeter, Sch Med, Inst Biomed & Clin Sci, Exeter, Devon, England.
-
- Wennauer, Roman (author)
- Univ Tartu, Estonian Genome Ctr, EE-50090 Tartu, Estonia.;Erasmus Univ, Med Ctr, Dept Internal Med, Rotterdam, Netherlands.
-
- Wiltshire, Steven (author)
- Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.
-
- Wood, Andrew R (author)
- Univ Oxford, Nuffield Dept Med, Ctr Cellular & Mol Physiol, Oxford, England.;Univ Exeter, Sch Med, Genet Complex Traits, Exeter, Devon, England.
-
- Zeggini, Eleftheria (author)
- Wellcome Trust Sanger Inst, Hinxton, England.
-
- Dunham, Ian (author)
- Wellcome Trust Sanger Inst, Hinxton, England.;European Mol Biol Lab, EBI, Hinxton, England.
-
- Birney, Ewan (author)
- Wellcome Trust Sanger Inst, Hinxton, England.;European Mol Biol Lab, EBI, Hinxton, England.
-
- Pasquali, Lorenzo (author)
- Univ Cambridge, Sch Clin Med, Inst Metab Sci, Med Res Council MRC Epidemiol Unit, Cambridge, England.;Univ London Imperial Coll Sci Technol & Med, Genom Common Dis, London, England.;Germans Trias & Pujol Univ Hosp & Res Inst, Div Endocrinol, Badalona, Spain.;Josep Carreras Leukaemia Res Inst, Badalona, Spain.;CIBERDEM, Barcelona, Spain.
-
- Ferrer, Jorge (author)
- Univ London Imperial Coll Sci Technol & Med, Dept Med, London, England.;Inst Invest Biomed August Pi & Sunyer, Ctr Esther Koplowitz, Barcelona, Spain.
-
Loos, Ruth J F (author)
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- Dupuis, Josée (author)
- Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA.;NHLBI, Framingham Heart Study, Framingham, MA USA.
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- Florez, Jose C (author)
- Broad Inst Harvard & MIT, Program Med & Populat Genet, Cambridge, MA USA.;Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA.;Massachusetts Gen Hosp, Diabet Res Ctr, Boston, MA 02114 USA.
-
- Boerwinkle, Eric (author)
- Univ Texas Hlth Sci Ctr Houston, Human Genet Ctr, Houston, TX 77030 USA.;Baylor Coll Med, Human Genome Sequencing Ctr, Houston, TX 77030 USA.
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- Univ Minnesota, Div Epidemiol & Community Hlth, Minneapolis, MN USA.
-
- van Duijn, Cornelia (author)
- Erasmus Univ, Med Ctr, Dept Epidemiol, Rotterdam, Netherlands.;Netherlands Consortium Hlth Ageing, Netherlands Genom Initiat, Rotterdam, Netherlands.;Ctr Med Syst Biol, Rotterdam, Netherlands.
-
- Sijbrands, Eric (author)
- Univ Tartu, Estonian Genome Ctr, EE-50090 Tartu, Estonia.;Erasmus Univ, Med Ctr, Dept Internal Med, Rotterdam, Netherlands.
-
Meigs, James B (author)
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Hu, Frank B (author)
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- Thorsteinsdottir, Unnur (author)
- deCODE Genet Amgen Inc, Reykjavik, Iceland.;Univ Iceland, Fac Med, Reykjavik, Iceland.
-
- Stefansson, Kari (author)
- deCODE Genet Amgen Inc, Reykjavik, Iceland.;Univ Iceland, Fac Med, Reykjavik, Iceland.
-
- Lakka, Timo A (author)
- Kuopio Res Inst Exercise Med, Kuopio, Finland.;Univ Eastern Finland, Inst Biomed Physiol, Kuopio, Finland.;Kuopio Univ Hosp, Dept Clin Physiol & Nucl Med, SF-70210 Kuopio, Finland.
-
Rauramaa, Rainer (author)
-
- Stumvoll, Michael (author)
- Univ Leipzig, Integrated Treatment & Res IFB Ctr Adipos Dis, D-04109 Leipzig, Germany.;Univ Leipzig, Dept Med, D-04109 Leipzig, Germany.
-
Pedersen, Nancy L (author)
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Lind, Lars (author)
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- Keinanen-Kiukaanniemi, Sirkka M (author)
- Univ Oulu, Inst Hlth Sci, Fac Med, Oulu, Finland.;Oulu Univ Hosp, Unit Gen Practice, Oulu, Finland.
-
- Korpi-Hyövälti, Eeva (author)
- South Ostrobothnia Cent Hosp, Seinajoki, Finland.
-
Saaristo, Timo E (author)
-
- Saltevo, Juha (author)
- Cent Finland Cent Hosp, Dept Med, Jyvasklya, Finland.
-
- Kuusisto, Johanna (author)
- Univ Eastern Finland, Dept Med, Kuopio, Finland.;Kuopio Univ Hosp, SF-70210 Kuopio, Finland.
-
- Laakso, Markku (author)
- Univ Eastern Finland, Dept Med, Kuopio, Finland.;Kuopio Univ Hosp, SF-70210 Kuopio, Finland.
-
- Metspalu, Andres (author)
- Univ Tartu, Estonian Genome Ctr, EE-50090 Tartu, Estonia.;Univ Tartu, Inst Mol & Cell Biol, EE-50090 Tartu, Estonia.
-
- Erbel, Raimund (author)
- Univ Duisdurg Essen, Univ Hosp Essen, West German Heart Ctr, Clin Cardiol, Essen, Germany.
-
- Jöcke, Karl-Heinz (author)
- Univ Eastern Finland, Inst Biomed Physiol, Kuopio, Finland.
-
- Moebus, Susanne (author)
- Univ Hosp Essen, Inst Med Informat Biometry & Epidemiol, Essen, Germany.
-
- Ripatti, Samuli (author)
- Stanford Univ, Dept Genet, Stanford, CA 94305 USA.;Wellcome Trust Sanger Inst, Hinxton, England.;Finnish Inst Mol Med, Helsinki, Finland.;Univ Helsinki, Dept Publ Hlth, Hjelt Inst, Helsinki, Finland.;Natl Inst Hlth & Welf, Publ Hlth Genom Unit, Helsinki, Finland.
-
- Salomaa, Veikko (author)
- Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Helsinki, Finland.
-
- Ingelsson, Erik (author)
- Uppsala universitet,Molekylär epidemiologi,Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.
-
- Boehm, Bernhard O (author)
- Univ Med Ctr Ulm, Dept Internal Med, Div Endocrinol & Diabet, Ulm, Germany.;Univ London Imperial Coll Sci Technol & Med, Lee Kong Chian Sch Med, London SW7 2AZ, England.;Nanyang Technol Univ, Singapore 639798, Singapore.
-
- Bergman, Richard N (author)
- Cedars Sinai Med Ctr, Diabet & Obes Res Inst, Los Angeles, CA 90048 USA.
-
- Collins, Francis S (author)
- Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England.;NHGRI, US NIH, Bethesda, MD 20892 USA.
-
Mohlke, Karen L (author)
-
- Koistinen, Heikki (author)
- Univ Tartu, Estonian Genome Ctr, EE-50090 Tartu, Estonia.;Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Helsinki, Finland.;Univ Helsinki, Cent Hosp, Dept Med, Div Endocrinol, Helsinki, Finland.;Minerva Fdn, Helsinki, Finland.
-
- Tuomilehto, Jaakko (author)
- Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Helsinki, Finland.;Hosp Univ La Paz, Inst Invest Sanitaria, Madrid, Spain.;Danube Univ Krems, Ctr Vasc Prevent, Krems, Austria.;King Abdulaziz Univ, Diabet Res Grp, Jeddah 21413, Saudi Arabia.
-
- Hveem, Kristian (author)
- Norwegian Univ Sci & Technol, Dept Publ Hlth & Gen Practice, Nord Trondelag Hlth Study HUNT Res Ctr, Levanger, Norway.
-
- Njølstad, Inger (author)
- Univ Tromso, Fac Hlth Sci, Dept Community Med, Tromso, Norway.
-
- Deloukas, Panagiotis (author)
- Wellcome Trust Sanger Inst, Hinxton, England.;Queen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, London, England.
-
Donnelly, Peter J (author)
-
- Frayling, Timothy M (author)
- Univ Oxford, Nuffield Dept Med, Ctr Cellular & Mol Physiol, Oxford, England.;Univ Exeter, Sch Med, Genet Complex Traits, Exeter, Devon, England.
-
Hattersley, Andrew T (author)
-
- de Faire, Ulf (author)
- Karolinska Institutet,Karolinska Inst, Inst Environm Med, Div Cardiovasc Epidemiol, S-10401 Stockholm, Sweden.
-
- Hamsten, Anders (author)
- Karolinska Institutet,Karolinska Inst, Dept Med Solna, Atherosclerosis Res Unit, Stockholm, Sweden.
-
- Illig, Thomas (author)
- German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Res Unit Mol Epidemiol, Neuherberg, Germany.;Hannover Med Sch, Hannover Unified Biobank, Hannover, Germany.
-
- Peters, Annette (author)
- German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Epidemiol 2, Neuherberg, Germany.;German Ctr Diabet Res, Neuherberg, Germany.;Partner Site Munich Heart Alliance, DZHK German Ctr Cardiovasc Res, Munich, Germany.
-
- Cauchi, Stephane (author)
- European Genom Inst Diabet, Lille Inst Biol, Lille, France.
-
- Sladek, Rob (author)
- Ctr Hosp Univ Montreal, Ctr Rech, Montreal Diabet Res Ctr, Montreal, PQ, Canada.;McGill Univ, Montreal, PQ, Canada.;Genome Quebec Innovat Ctr, Montreal, PQ, Canada.
-
- Froguel, Philippe (author)
- Univ London Imperial Coll Sci Technol & Med, Genom Common Dis, London, England.;CNRS, UMR 8199, Inst Biol, Lille, France.;Univ Lille 2, Inst Pasteur, Lille, France.
-
- Hansen, Torben (author)
- Univ Copenhagen, Fac Hlth & Med Sci, Novo Nordisk Fdn Ctr Basic Metab Res, Copenhagen, Denmark.;Univ Southern Denmark, Fac Hlth Sci, Odense, Denmark.
-
- Pedersen, Oluf (author)
- Univ Copenhagen, Fac Hlth & Med Sci, Novo Nordisk Fdn Ctr Basic Metab Res, Copenhagen, Denmark.
-
- Morris, Andrew D (author)
- Univ Edinburgh, Usher Inst Populat Hlth Sci & Informat, Edinburgh, Midlothian, Scotland.
-
- Palmer, Collin N A (author)
- Univ Dundee, Ninewells Hosp, Biomed Res Inst, Ctr Diabet Res, Dundee, Scotland.;Univ Dundee, Ninewells Hosp, Biomed Res Inst, Pharmacogen Ctr, Dundee, Scotland.
-
- Kathiresan, Sekar (author)
- Broad Inst Harvard & MIT, Cambridge, MA USA.;Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA.;Massachusetts Gen Hosp, Cardiovasc Res Ctr, Boston, MA 02114 USA.
-
- Melander, Olle (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups,Lund Univ, Scania Univ Hosp, Dept Clin Sci Malmo, Ctr Diabet, Malmo, Sweden.
-
- Nilsson, Peter (author)
- Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Lund Univ, Scania Univ Hosp, Dept Clin Sci Malmo, Ctr Diabet, Malmo, Sweden.
-
- Groop, Leif (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Finnish Inst Mol Med, Helsinki, Finland.;Lund Univ, Scania Univ Hosp, Dept Clin Sci Malmo, Ctr Diabet, Malmo, Sweden.
-
- Barroso, Inês (author)
- Wellcome Trust Sanger Inst, Hinxton, England.;Univ Cambridge, Metab Res Labs, Wellcome Trust MRC Inst Metab Sci, Cambridge, England.;Cambridge Biomed Res Ctr, Natl Inst Hlth Res, Cambridge, England.
-
- Langenberg, Claudia (author)
- Univ Cambridge, Sch Clin Med, Inst Metab Sci, Med Res Council MRC Epidemiol Unit, Cambridge, England.
-
- Wareham, Nicholas J (author)
- Univ Cambridge, Sch Clin Med, Inst Metab Sci, Med Res Council MRC Epidemiol Unit, Cambridge, England.
-
- O'Callaghan, Christopher A (author)
- Univ Oxford, Nuffield Dept Med, Ctr Cellular & Mol Physiol, Oxford, England.
-
Gloyn, Anna L (author)
-
- Altshuler, David (author)
- Broad Inst Harvard & MIT, Cambridge, MA USA.;Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA.;Massachusetts Gen Hosp, Diabet Res Ctr, Boston, MA 02114 USA.;Harvard Univ, Sch Med, Dept Genet, Boston, MA USA.;Harvard Univ, Sch Med, Dept Mol Biol, Boston, MA USA. Univ Liverpool, Dept Biostat, Liverpool L69 3BX, Merseyside, England.
-
- Boehnke, Michael (author)
- Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA.
-
- Teslovich, Tanya M (author)
- Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA.
-
- McCarthy, Mark I (author)
- Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.;Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England.;Churchill Hosp, Biomed Res Ctr, Oxford Natl Inst Hlth Res, Oxford OX3 7LJ, England.
-
- Morris, Andrew P (author)
- Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.;Univ Tartu, Estonian Genome Ctr, EE-50090 Tartu, Estonia.;Univ Liverpool, Dept Mol & Clin Pharmacol, Liverpool L69 3BX, Merseyside, England.
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Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England;Stanford Univ, Dept Genet, Stanford, CA 94305 USA. Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England. (creator_code:org_t)
- 2015-11-09
- 2015
- English.
-
In: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 47:12, s. 1415-1415
- Related links:
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Abstract
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- We performed fine mapping of 39 established type 2 diabetes (T2D) loci in 27,206 cases and 57,574 controls of European ancestry. We identified 49 distinct association signals at these loci, including five mapping in or near KCNQ1. 'Credible sets' of the variants most likely to drive each distinct signal mapped predominantly to noncoding sequence, implying that association with T2D is mediated through gene regulation. Credible set variants were enriched for overlap with FOXA2 chromatin immunoprecipitation binding sites in human islet and liver cells, including at MTNR1B, where fine mapping implicated rs10830963 as driving T2D association. We confirmed that the T2D risk allele for this SNP increases FOXA2-bound enhancer activity in islet- and liver-derived cells. We observed allele-specific differences in NEUROD1 binding in islet-derived cells, consistent with evidence that the T2D risk allele increases islet MTNR1B expression. Our study demonstrates how integration of genetic and genomic information can define molecular mechanisms through which variants underlying association signals exert their effects on disease.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- NATURVETENSKAP -- Biologi -- Genetik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Genetics (hsv//eng)
Keyword
- ANDIS
- diabetes
- diabetics
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Gaulton, Kyle J
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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NATURAL SCIENCES
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Nature Genetics
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Lund University
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Umeå University
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Karolinska Institutet
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Uppsala University