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Accuracy of 1-Hour ...
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Ahuja, VasudhaInstitute for Molecular Medicine Finland (FIMM),University of Helsinki
(författare)
Accuracy of 1-Hour Plasma Glucose During the Oral Glucose Tolerance Test in Diagnosis of Type 2 Diabetes in Adults : A Meta-analysis
- Artikel/kapitelEngelska2021
Förlag, utgivningsår, omfång ...
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2021-03-15
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American Diabetes Association,2021
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8 s.
Nummerbeteckningar
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LIBRIS-ID:oai:lup.lub.lu.se:88d43823-4d4c-4e2e-a23d-d854397ab228
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https://lup.lub.lu.se/record/88d43823-4d4c-4e2e-a23d-d854397ab228URI
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https://doi.org/10.2337/dc20-1688DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:for swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
Anmärkningar
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OBJECTIVE: One-hour plasma glucose (1-h PG) during the oral glucose tolerance test (OGTT) is an accurate predictor of type 2 diabetes. We performed a meta-analysis to determine the optimum cutoff of 1-h PG for detection of type 2 diabetes using 2-h PG as the gold standard. RESEARCH DESIGN AND METHODS: We included 15 studies with 35,551 participants from multiple ethnic groups (53.8% Caucasian) and 2,705 newly detected cases of diabetes based on 2-h PG during OGTT. We excluded cases identified only by elevated fasting plasma glucose and/or HbA1c. We determined the optimal 1-h PG threshold and its accuracy at this cutoff for detection of diabetes (2-h PG ≥11.1 mmol/L) using a mixed linear effects regression model with different weights to sensitivity/specificity (2/3, 1/2, and 1/3). RESULTS: Three cutoffs of 1-h PG, at 10.6 mmol/L, 11.6 mmol/L, and 12.5 mmol/L, had sensitivities of 0.95, 0.92, and 0.87 and specificities of 0.86, 0.91, and 0.94 at weights 2/3, 1/2, and 1/3, respectively. The cutoff of 11.6 mmol/L (95% CI 10.6, 12.6) had a sensitivity of 0.92 (0.87, 0.95), specificity of 0.91 (0.88, 0.93), area under the curve 0.939 (95% confidence region for sensitivity at a given specificity: 0.904, 0.946), and a positive predictive value of 45%. CONCLUSIONS: The 1-h PG of ≥11.6 mmol/L during OGTT has a good sensitivity and specificity for detecting type 2 diabetes. Prescreening with a diabetes-specific risk calculator to identify high-risk individuals is suggested to decrease the proportion of false-positive cases. Studies including other ethnic groups and assessing complication risk are warranted.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Aronen, PasiHelsinki University Central Hospital,University of Helsinki
(författare)
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Pramodkumar, T. A.Madras Diabetes Research Foundation
(författare)
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Looker, HelenNational Institute of Diabetes and Digestive and Kidney Diseases, Phoenix
(författare)
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Chetrit, AngelaGertner Institute for Epidemiology and Health Policy Research
(författare)
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Bloigu, Aini H.University of Oulu
(författare)
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Juutilainen, AuniUniversity of Eastern Finland
(författare)
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Bianchi, CristinaUniversity Hospital of Pisa
(författare)
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La Sala, LuciaIRCCS Multimedica
(författare)
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Anjana, Ranjit MohanMadras Diabetes Research Foundation
(författare)
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Pradeepa, RajendraMadras Diabetes Research Foundation
(författare)
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Venkatesan, UlagamadesanMadras Diabetes Research Foundation
(författare)
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Jebarani, SarvananMadras Diabetes Research Foundation
(författare)
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Baskar, ViswanathanMadras Diabetes Research Foundation
(författare)
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Fiorentino, Teresa VanessaUniversity Magna Graecia
(författare)
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Timpel, PatrickDresden University of Technology
(författare)
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DeFronzo, Ralph A.University of Texas Health Science Centre
(författare)
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Ceriello, AntonioIRCCS Multimedica
(författare)
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Del Prato, StefanoUniversity Hospital of Pisa
(författare)
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Abdul-Ghani, MuhammadUniversity of Texas Health Science Centre
(författare)
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Keinänen-Kiukaanniemi, SirkkaUniversity of Oulu
(författare)
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Dankner, RachelTel-Aviv University,Gertner Institute for Epidemiology and Health Policy Research
(författare)
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Bennett, Peter H.National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix
(författare)
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Knowler, William C.National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix
(författare)
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Schwarz, PeterUniversity Clinic Carl Gustav Carus at the TU Dresden,Dresden University of Technology,German Center for Diabetes Research
(författare)
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Sesti, GiorgioSapienza University of Rome
(författare)
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Oka, RieHokuriku Central Hospital
(författare)
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Mohan, ViswanathanMadras Diabetes Research Foundation
(författare)
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Groop, LeifLund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,Institute for Molecular Medicine Finland (FIMM),University of Helsinki(Swepub:lu)endo-lgr
(författare)
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Tuomilehto, JaakkoKing Abdulaziz University,University of Helsinki,Finnish National Institute for Health and Welfare
(författare)
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Ripatti, SamuliUniversity of Helsinki,Institute for Molecular Medicine Finland (FIMM),Broad Institute(Swepub:lu)med-sur
(författare)
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Bergman, MichaelNew York University
(författare)
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Tuomi, TiinamaijaLund University,Lunds universitet,Diabetiska komplikationer,Forskargrupper vid Lunds universitet,Diabetic Complications,Lund University Research Groups,Helsinki University Central Hospital,Folkhälsan Research Center,University of Helsinki,Institute for Molecular Medicine Finland (FIMM)(Swepub:lu)ti8736tu
(författare)
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Institute for Molecular Medicine Finland (FIMM)University of Helsinki
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Diabetes Care: American Diabetes Association44:4, s. 1062-10691935-55480149-5992
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Till lärosätets databas
- Av författaren/redakt...
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Ahuja, Vasudha
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Aronen, Pasi
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Pramodkumar, T. ...
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Looker, Helen
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Chetrit, Angela
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Bloigu, Aini H.
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visa fler...
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Juutilainen, Aun ...
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Bianchi, Cristin ...
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La Sala, Lucia
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Anjana, Ranjit M ...
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Pradeepa, Rajend ...
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Venkatesan, Ulag ...
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Jebarani, Sarvan ...
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Baskar, Viswanat ...
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Fiorentino, Tere ...
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Timpel, Patrick
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DeFronzo, Ralph ...
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Ceriello, Antoni ...
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Del Prato, Stefa ...
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Abdul-Ghani, Muh ...
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Keinänen-Kiukaan ...
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Dankner, Rachel
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Bennett, Peter H ...
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Knowler, William ...
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Schwarz, Peter
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Sesti, Giorgio
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Oka, Rie
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Mohan, Viswanath ...
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Groop, Leif
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Tuomilehto, Jaak ...
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Ripatti, Samuli
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Bergman, Michael
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Tuomi, Tiinamaij ...
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visa färre...
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Lunds universitet