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  • Ariceta, Gema (författare)

Guideline for the investigation and initial therapy of diarrhea-negative hemolytic uremic syndrome

  • Artikel/kapitelEngelska2009

Förlag, utgivningsår, omfång ...

  • 2009-04-01
  • Springer Science and Business Media LLC,2009

Nummerbeteckningar

  • LIBRIS-ID:oai:lup.lub.lu.se:898f9612-5b49-4dd3-8afc-4e88488549f7
  • https://lup.lub.lu.se/record/1370946URI
  • https://doi.org/10.1007/s00467-008-0964-1DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:vet swepub-contenttype

Anmärkningar

  • This guideline for the investigation and initial treatment of atypical hemolytic uremic syndrome (HUS) is intended to offer an approach based on opinion, as evidence is lacking. It builds on the current ability to identify the etiology of specific diagnostic sub-groups of HUS. HUS in children is mostly due to infection, enterohemorrhagic Escherichia coli (EHEC), Shigella dysenteriae type 1 in some geographic regions, and invasive Streptococcus pneumoniae. These sub-groups are relatively straightforward to diagnose. Their management, which is outside the remit of this guideline, is related to control of infection where that is necessary and supportive measures for the anemia and acute renal failure. A thorough investigation of the remainder of childhood HUS cases, commonly referred to as "atypical" HUS, will reveal a risk factor for the syndrome in approximately 60% of cases. Disorders of complement regulation are, numerically, the most important. The outcome for children with atypical HUS is poor, and, because of the rarity of these disorders, clinical experience is scanty. Some cases of complement dysfunction appear to respond to plasma therapy. The therapeutic part of this guideline is the consensus of the contributing authors and is based on limited information from uncontrolled studies. The guideline proposes urgent and empirical plasmapheresis replacement with whole plasma fraction for the first month after diagnosis. This should only be undertaken in specialized pediatric nephrology centers where appropriate medical and nursing skills are available. The guideline includes defined terminology and audit points so that the early clinical effectiveness of the strategy can be evaluated.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Besbas, Nesrin (författare)
  • Johnson, Sally (författare)
  • Karpman, DianaLund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Pediatrisk nefrologi,Forskargrupper vid Lunds universitet,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Pediatric Nephrology,Lund University Research Groups(Swepub:lu)pedi-dka (författare)
  • Landau, Daniel (författare)
  • Licht, Christoph (författare)
  • Loirat, Chantal (författare)
  • Pecoraro, Carmine (författare)
  • Taylor, C. Mark (författare)
  • Van de Kar, Nicole (författare)
  • VandeWalle, Johan (författare)
  • Zimmerhackl, Lothar B. (författare)
  • Pediatrik, LundSektion V (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Pediatric Nephrology: Springer Science and Business Media LLC24:4, s. 687-6961432-198X0931-041X

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