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Characterization of...
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Laroy, MaartenKatholieke Univ Leuven, Belgium
(author)
Characterization of gray matter volume changes from one week to 6 months after termination of electroconvulsive therapy in depressed patients
- Article/chapterEnglish2024
Publisher, publication year, extent ...
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ELSEVIER SCIENCE INC,2024
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Numbers
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LIBRIS-ID:oai:DiVA.org:liu-207225
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-207225URI
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https://doi.org/10.1016/j.brs.2024.07.015DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Funding Agencies|Research Foundation Flanders (FWO) [1168821 N]; KU Leuven Research Fund [C24/18/095]; KU Leuven Sequoia Fund for Research on Aging and Mental Health; Western Norway Regional Health Authority Grant [912238]; Lundbeck Foundation
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Background: Increased gray matter volume (GMV) following electroconvulsive therapy (ECT) has been welldocumented, with limited studies reporting a subsequent decrease in GMV afterwards. Objective: This study characterized the reversion pattern of GMV after ECT and its association with clinical depression outcome, using multi-site triple time-point data from the Global ECT-MRI Research Collaboration (GEMRIC). Methods: 86 subjects from the GEMRIC database were included, and GMV in 84 regions-of-interest (ROI) was obtained from automatic segmentation of T1 MRI images at three timepoints: pre-ECT (T0), within one-week post-ECT (T1), and one to six months post-ECT (T2). RM-ANOVAs were used to assess longitudinal changes and LMM analyses explored associations between GMV changes and demographical and clinical characteristics. Results: 63 of the 84 ROIs showed a significant increase-and-decrease pattern (RM-ANOVA, Bonferroni corrected p < 0.00059). Post hoc tests indicated a consistent pattern in each of these 63 ROIs: significant increase from T0 to T1in GMV, followed by significant decrease from T1 to T2 and no difference between T0 and T2, except for both amygdalae, right hippocampus and pars triangularis, which showed the same increase and decrease but GMV at T2 remained higher compared to T0. No consistent relationship was found between GMV change pattern and clinical status. Conclusion: The GEMRIC cohort confirmed a rapid increase of GMV after ECT followed by reversion of GMV one to six months thereafter. The lack of association between the GMV change pattern and depression outcome scores implies a transient neurobiological effect of ECT unrelated to clinical improvement.
Subject headings and genre
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Bouckaert, FilipKatholieke Univ Leuven, Belgium; Univ Psychiat Ctr KU Leuven, Belgium
(author)
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Ousdal, Olga ThereseHaukeland Hosp, Norway; Univ Bergen, Norway
(author)
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Dols, AnnemiekeUMC Utrecht, Netherlands; Amsterdam UMC, Netherlands
(author)
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Rhebergen, DidiAmsterdam UMC, Netherlands; GGZ Cent, Netherlands
(author)
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van Exel, EricAmsterdam UMC, Netherlands
(author)
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van Wingen, GuidoAmsterdam UMC, Netherlands; Amsterdam Neurosci, Netherlands
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van Waarde, JeroenRijnstate Hosp, Netherlands
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Verdijk, JoeyRijnstate Hosp, Netherlands; Univ Twente, Netherlands
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Kessler, UteUniv Bergen, Norway
(author)
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Bartsch, HaukeHaukeland Hosp, Norway; Univ Bergen, Norway
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Jorgensen, Martin BalslevPsychiat Ctr Copenhagen, Denmark; Univ Copenhagen, Denmark
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Paulson, Olaf B.Univ Copenhagen, Denmark; Rigshosp, Denmark
(author)
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Nordanskog, PiaLinköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten,Region Östergötland, Psykiatriska kliniken i Linköping(Swepub:liu)piano33
(author)
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Prudic, JoanColumbia Univ, NY USA
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Sienaert, PascalKatholieke Univ Leuven, Belgium
(author)
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Vandenbulcke, MathieuKatholieke Univ Leuven, Belgium; Univ Psychiat Ctr KU Leuven, Belgium
(author)
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Oltedal, LeifHaukeland Hosp, Norway; Univ Bergen, Norway
(author)
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Emsell, LouiseKatholieke Univ Leuven, Belgium; Univ Psychiat Ctr KU Leuven, Belgium; Katholieke Univ Leuven, Belgium
(author)
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Katholieke Univ Leuven, BelgiumKatholieke Univ Leuven, Belgium; Univ Psychiat Ctr KU Leuven, Belgium
(creator_code:org_t)
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In:Brain Stimulation: ELSEVIER SCIENCE INC17:4, s. 876-8861935-861X1876-4754
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Laroy, Maarten
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Bouckaert, Filip
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Ousdal, Olga The ...
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Dols, Annemieke
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Rhebergen, Didi
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van Exel, Eric
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van Wingen, Guid ...
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van Waarde, Jero ...
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Verdijk, Joey
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Kessler, Ute
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Bartsch, Hauke
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Paulson, Olaf B.
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Nordanskog, Pia
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Prudic, Joan
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Sienaert, Pascal
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Vandenbulcke, Ma ...
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Oltedal, Leif
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Emsell, Louise
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