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ABO Genotyping find...
ABO Genotyping finds more A2 to B kidney transplant opportunities than lectin-based subtyping
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- Joseph, Abigail (författare)
- Brigham and Women's Hospital / Harvard Medical School
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- Murray, Cody J. (författare)
- Southwest Immunodiagnostics, Inc.
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- Novikov, Natasha D. (författare)
- Harvard Medical School,Brigham and Women's Hospital / Harvard Medical School
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visa fler...
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- Velliquette, Randall W. (författare)
- New York Blood Center
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- Vege, Sunitha (författare)
- New York Blood Center
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- Halls, Justin B.L. (författare)
- Harvard Medical School,Brigham and Women's Hospital / Harvard Medical School
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- Mah, Helen H. (författare)
- Brigham and Women's Hospital / Harvard Medical School
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- Dellagatta, Jamie L. (författare)
- Brigham and Women's Hospital / Harvard Medical School
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- Comeau, Edward (författare)
- Brigham and Women's Hospital / Harvard Medical School
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- Aguad, Maria (författare)
- Brigham and Women's Hospital / Harvard Medical School
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- Kaufman, Richard M. (författare)
- Harvard Medical School,Brigham and Women's Hospital / Harvard Medical School
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- Olsson, Martin L. (författare)
- Lund University,Lunds universitet,Transfusionsmedicin,Forskargrupper vid Lunds universitet,Transfusion Medicine,Lund University Research Groups,Region Skåne
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- Guleria, Indira (författare)
- Brigham and Women's Hospital / Harvard Medical School,Harvard Medical School
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- Stowell, Sean R. (författare)
- Harvard Medical School,Brigham and Women's Hospital / Harvard Medical School
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- Milford, Edgar L. (författare)
- Harvard Medical School,Brigham and Women's Hospital / Harvard Medical School
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- Hult, Annika K. (författare)
- Lund University,Lunds universitet,Transfusionsmedicin,Forskargrupper vid Lunds universitet,Transfusion Medicine,Lund University Research Groups,Region Skåne
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- Yeung, Melissa Y. (författare)
- Harvard Medical School,Brigham and Women's Hospital / Harvard Medical School
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- Westhoff, Connie M. (författare)
- New York Blood Center
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- Murphey, Cathi L. (författare)
- Southwest Immunodiagnostics, Inc.
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- Lane, William J. (författare)
- Brigham and Women's Hospital / Harvard Medical School,Harvard Medical School
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visa färre...
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Brigham and Women's Hospital / Harvard Medical School Southwest Immunodiagnostics, Inc (creator_code:org_t)
- Elsevier BV, 2023
- 2023
- Engelska 8 s.
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Ingår i: American Journal of Transplantation. - : Elsevier BV. - 1600-6135. ; 23:4, s. 512-519
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- ABO compatibility is important for kidney transplantation, with longer waitlist times for blood group B kidney transplant candidates. However, kidneys from non-A1 (eg, A2) subtype donors, which express less A antigen, can be safely transplanted into group B recipients. ABO subtyping is routinely performed using anti-A1 lectin, but DNA-based genotyping is also possible. Here, we compare lectin and genotyping testing. Lectin and genotype subtyping was performed on 554 group A deceased donor samples at 2 transplant laboratories. The findings were supported by 2 additional data sets of 210 group A living kidney donors and 124 samples with unclear lectin testing sent to a reference laboratory. In deceased donors, genotyping found 65% more A2 donors than lectin testing, most with weak lectin reactivity, a finding supported in living donors and samples sent for reference testing. DNA sequencing and flow cytometry showed that the discordances were because of several factors, including transfusion, small variability in A antigen levels, and rare ABO∗A2.06 and ABO∗A2.16 sequences. Although lectin testing is the current standard for transplantation subtyping, genotyping is accurate and could increase A2 kidney transplant opportunities for group B candidates, a difference that should reduce group B wait times and improve transplant equity.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Nyckelord
- ABO genotyping
- ABO incompatibility
- Dolichos biflorus lectin
- donors and donation
- kidney transplantation/nephrology
- molecular biology
- solid organ transplantation
- translational research/science
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Joseph, Abigail
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Murray, Cody J.
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Novikov, Natasha ...
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Velliquette, Ran ...
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Vege, Sunitha
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Halls, Justin B. ...
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visa fler...
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Mah, Helen H.
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Dellagatta, Jami ...
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Comeau, Edward
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Aguad, Maria
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Kaufman, Richard ...
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Olsson, Martin L ...
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Guleria, Indira
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Stowell, Sean R.
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Milford, Edgar L ...
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Hult, Annika K.
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Yeung, Melissa Y ...
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Westhoff, Connie ...
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Murphey, Cathi L ...
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Lane, William J.
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Hematologi
- Artiklar i publikationen
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American Journal ...
- Av lärosätet
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Lunds universitet