Search: (WFRF:(Fitzpatrick Annette)) mspu:(article)
> (2010-2014) >
Body mass index is ...
Body mass index is associated with biological CSF markers of core brain pathology of Alzheimer's disease
-
Ewers, Michael (author)
-
Schmitz, Susanne (author)
-
- Hansson, Oskar (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups
-
show more...
-
Walsh, Cathal (author)
-
Fitzpatrick, Annette (author)
-
Bennett, David (author)
-
- Minthon, Lennart (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups
-
Trojanowski, John Q. (author)
-
Shaw, Leslie M. (author)
-
Faluyi, Yetunde O. (author)
-
Vellas, Bruno (author)
-
Dubois, Bruno (author)
-
- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
-
Buerger, Katharina (author)
-
Teipel, Stefan J. (author)
-
Weiner, Michael (author)
-
Hampel, Harald (author)
-
show less...
-
(creator_code:org_t)
- Elsevier BV, 2012
- 2012
- English.
-
In: Neurobiology of Aging. - : Elsevier BV. - 1558-1497 .- 0197-4580. ; 33:8, s. 1599-1608
- Related links:
-
http://dx.doi.org/10...
-
show more...
-
https://europepmc.or...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
https://gup.ub.gu.se...
-
show less...
Abstract
Subject headings
Close
- Weight changes are common in aging and Alzheimer's disease (AD) and postmortem findings suggest a relation between lower body mass index (BMI) and increased AD brain pathology. In the current multicenter study, we tested whether lower BMI is associated with higher core AD brain pathology as assessed by cerebrospinal fluid (CSF)-based biological markers of AD in 751 living subjects: 308 patients with AD, 296 subjects with amnestic mild cognitive impairment (MCI), and 147 elderly healthy controls (HC). Based upon a priori cutoff values on CSF concentration of total tau and beta-amyloid (A beta(1-42)), subjects were binarized into a group with abnormal CSF biomarker signature (CSF+) and those without (CSF-). Results showed that BMI was significantly lower in the CSF+ when compared with the CSF- group (F = 27.7, df = 746, p < 0.001). There was no interaction between CSF signature and diagnosis or apolipoprotein E (ApoE) genotype. In conclusion, lower BMI is indicative of AD pathology as assessed with CSF-based biomarkers in demented and nondemented elderly subjects. Published by Elsevier Inc.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Keyword
- Alzheimer's disease
- Body mass index
- Cerebrospinal fluid
- Tau protein
- A beta(1-42)
- Alzheimer's disease; Body mass index; Cerebrospinal fluid; Tau protein; Aβ1–42
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database
- By the author/editor
-
Ewers, Michael
-
Schmitz, Susanne
-
Hansson, Oskar
-
Walsh, Cathal
-
Fitzpatrick, Ann ...
-
Bennett, David
-
show more...
-
Minthon, Lennart
-
Trojanowski, Joh ...
-
Shaw, Leslie M.
-
Faluyi, Yetunde ...
-
Vellas, Bruno
-
Dubois, Bruno
-
Blennow, Kaj, 19 ...
-
Buerger, Kathari ...
-
Teipel, Stefan J ...
-
Weiner, Michael
-
Hampel, Harald
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Neurology
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Psychiatry
- Articles in the publication
-
Neurobiology of ...
- By the university
-
Lund University
-
University of Gothenburg