Developmental programming : State-of-the-science and future directions: Summary from a Pennington Biomedical symposium

OBJECTIVE: On December 8-9, 2014, the Pennington Biomedical Research Center convened a scientific symposium to review the state-of-the-science and future directions for the study of developmental programming of obesity and chronic disease. The objectives of the symposium were to discuss: (i) past and current scientific advances in animal models, population-based cohort studies, and human clinical trials, (ii) the state-of-the-science of epigenetic-based research, and (iii) considerations for future studies.RESULTS: This symposium provided a comprehensive assessment of the state of the scientific field and identified research gaps and opportunities for future research in order to understand the mechanisms contributing to the developmental programming of health and disease.CONCLUSIONS: Identifying the mechanisms which cause or contribute to developmental programming of future generations will be invaluable to the scientific and medical community. The ability to intervene during critical periods of prenatal and early postnatal life to promote lifelong health is the ultimate goal. Considerations for future research including the use of animal models, the study design in human cohorts with considerations about the timing of the intrauterine exposure, and the resulting tissue-specific epigenetic signature were extensively discussed and are presented in this meeting summary.

Gilmore, L AnnePennington Biomedical Research Center (författare)
Dunger, David BUniversity of Cambridge (författare)
Heijmans, Bas TLeiden University Medical Centre (författare)
Hivert, Marie-FranceHarvard University (författare)
Ling, CharlotteLund University,Lunds universitet,Diabetes - epigenetik,Forskargrupper vid Lunds universitet,Diabetes - Epigenetics,Lund University Research Groups(Swepub:lu)endo-cl0 (författare)
Martinez, J AlfredoUniversity of Navarra (författare)
Ozanne, Susan EUniversity of Cambridge (författare)
Simmons, Rebecca AUniversity of Pennsylvania (författare)
Szyf, MosheMcGill University (författare)
Waterland, Robert ABaylor College of Medicine (författare)
Redman, Leanne MPennington Biomedical Research Center (författare)
Ravussin, EricPennington Biomedical Research Center (författare)
Pennington Biomedical Research CenterUniversity of Cambridge (creator_code:org_t)

Av författaren/redakt...: Sutton, Elizabet ...; Gilmore, L Anne; Dunger, David B; Heijmans, Bas T; Hivert, Marie-Fr ...; Ling, Charlotte; visa fler...; Martinez, J Alfr ...; Ozanne, Susan E; Simmons, Rebecca ...; Szyf, Moshe; Waterland, Rober ...; Redman, Leanne M; Ravussin, Eric; visa färre...

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