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Design of a randomi...
Design of a randomized controlled trial of physical training and cancer (Phys-Can) - the impact of exercise intensity on cancer related fatigue, quality of life and disease outcome
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- Berntsen, Sveinung (författare)
- Uppsala universitet,Uppsala University,Uppsala University, Sweden; University of Agder, Norway,Livsstil och rehabilitering vid långvarig sjukdom
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- Aaronson, Neil K. (författare)
- Netherlands Cancer Institute, Netherlands
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- Buffart, Laurien (författare)
- Amsterdam UMC - Vrije Universiteit Amsterdam,Vrije University of Amsterdam Medical Centre, Netherlands; Vrije University of Amsterdam Medical Centre, Netherlands
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- Börjeson, Sussanne (författare)
- Linköpings universitet,Linköping University,Avdelningen för omvårdnad,Medicinska fakulteten,Region Östergötland, Onkologiska kliniken US
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- Demmelmaier, Ingrid, 1960- (författare)
- Uppsala universitet,Uppsala University,Livsstil och rehabilitering vid långvarig sjukdom,Uppsala University, Sweden
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- Hellbom, Maria (författare)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University, Sweden
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- Hojman, Pernille (författare)
- Copenhagen University Hospital, Denmark
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- Igelström, Helena, 1976- (författare)
- Uppsala universitet,Uppsala University,Livsstil och rehabilitering vid långvarig sjukdom,Uppsala University, Sweden
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- Johansson, Birgitta, 1959- (författare)
- Uppsala universitet,Uppsala University,Livsstil och rehabilitering vid långvarig sjukdom,Experimentell och klinisk onkologi,Uppsala University, Sweden
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- Pingel, Ronnie, 1978- (författare)
- Uppsala universitet,Uppsala University,Livsstil och rehabilitering vid långvarig sjukdom,Uppsala University, Sweden
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- Raastad, Truls (författare)
- Norwegian School of Sport Sciences,Norwegian School Sport Science, Norway
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- Velikova, Galina (författare)
- St James's University Hospital,University of Leeds, England
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- Åsenlöf, P., 1967- (författare)
- Uppsala universitet,Uppsala University,Fysioterapi,Uppsala University, Sweden
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- Nordin, Karin (författare)
- Uppsala universitet,Uppsala University,Uppsala University, Sweden; University of Agder, Norway,Livsstil och rehabilitering vid långvarig sjukdom
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(creator_code:org_t)
- 2017-03-27
- 2017
- Engelska.
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Ingår i: BMC Cancer. - : Springer Science and Business Media LLC. - 1471-2407. ; 17:1, s. 1-12
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://bmccancer.bi...
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://liu.diva-por... (primary) (Raw object)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Background: Cancer-related fatigue is a common problem in persons with cancer, influencing health-related quality of life and causing a considerable challenge to society. Current evidence supports the beneficial effects of physical exercise in reducing fatigue, but the results across studies are not consistent, especially in terms of exercise intensity. It is also unclear whether use of behaviour change techniques can further increase exercise adherence and maintain physical activity behaviour. This study will investigate whether exercise intensity affects fatigue and health related quality of life in persons undergoing adjuvant cancer treatment. In addition, to examine effects of exercise intensity on mood disturbance, adherence to oncological treatment, adverse effects from treatment, activities of daily living after treatment completion and return to work, and behaviour change techniques effect on exercise adherence. We will also investigate whether exercise intensity influences inflammatory markers and cytokines, and whether gene expressions following training serve as mediators for the effects of exercise on fatigue and health related quality of life. Methods/design: Six hundred newly diagnosed persons with breast, colorectal or prostate cancer undergoing adjuvant therapy will be randomized in a 2 × 2 factorial design to following conditions; A) individually tailored low-to-moderate intensity exercise with or without behaviour change techniques or B) individually tailored high intensity exercise with or without behaviour change techniques. The training consists of both resistance and endurance exercise sessions under the guidance of trained coaches. The primary outcomes, fatigue and health related quality of life, are measured by self-reports. Secondary outcomes include fitness, mood disturbance, adherence to the cancer treatment, adverse effects, return to activities of daily living after completed treatment, return to work as well as inflammatory markers, cytokines and gene expression. Discussion: The study will contribute to our understanding of the value of exercise and exercise intensity in reducing fatigue and improving health related quality of life and, potentially, clinical outcomes. The value of behaviour change techniques in terms of adherence to and maintenance of physical exercise behaviour in persons with cancer will be evaluated. Trial registration:NCT02473003 , October, 2014.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Idrottsvetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Sport and Fitness Sciences (hsv//eng)
Nyckelord
- Behaviour change techniques
- Biological mechanism
- Cancer
- Fatigue
- Physical exercise
- Quality of life
- Randomized controlled trial
- Behaviour change techniques
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Berntsen, Sveinu ...
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Aaronson, Neil K ...
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Buffart, Laurien
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Börjeson, Sussan ...
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Demmelmaier, Ing ...
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Hellbom, Maria
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visa fler...
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Hojman, Pernille
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Igelström, Helen ...
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Johansson, Birgi ...
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Pingel, Ronnie, ...
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Raastad, Truls
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Velikova, Galina
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Åsenlöf, P., 196 ...
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Nordin, Karin
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Idrottsvetenskap
- Artiklar i publikationen
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BMC Cancer
- Av lärosätet
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Lunds universitet
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Uppsala universitet
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Linköpings universitet