Impact of penalizing factor in a block-sequential regularized expectation maximization reconstruction algorithm for 18 F-fluorocholine PET-CT regarding image quality and interpretation

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Bjöersdorff, MimmiLund University,Lunds universitet,Nuklearmedicin, Malmö,Forskargrupper vid Lunds universitet,Nuclear medicine, Malmö,Lund University Research Groups,Skåne University Hospital (författare)

Impact of penalizing factor in a block-sequential regularized expectation maximization reconstruction algorithm for 18 F-fluorocholine PET-CT regarding image quality and interpretation

Artikel/kapitelEngelska2019

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2019-03-21
Springer Science and Business Media LLC,2019

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LIBRIS-ID:oai:lup.lub.lu.se:8a8dc3cd-2bbd-4569-84b6-e4c11ec8b8f4
https://lup.lub.lu.se/record/8a8dc3cd-2bbd-4569-84b6-e4c11ec8b8f4URI
https://doi.org/10.1186/s40658-019-0242-2DOI

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Språk:engelska
Sammanfattning på:engelska

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Background: Recently, the block-sequential regularized expectation maximization (BSREM) reconstruction algorithm was commercially introduced (Q.Clear, GE Healthcare, Milwaukee, WI, USA). However, the combination of noise-penalizing factor (β), acquisition time, and administered activity for optimal image quality has not been established for 18 F-fluorocholine (FCH). The aim was to compare image quality and diagnostic performance of different reconstruction protocols for patients with prostate cancer being examined with 18 F-FCH on a silicon photomultiplier-based PET-CT. Thirteen patients were included, injected with 4 MBq/kg, and images were acquired after 1 h. Images were reconstructed with frame durations of 1.0, 1.5, and 2.0 min using β of 150, 200, 300, 400, 500, and 550. An ordered subset expectation maximization (OSEM) reconstruction with a frame duration of 2.0 min was used for comparison. Images were quantitatively analyzed regarding standardized uptake values (SUV) in metastatic lymph nodes, local background, and muscle to obtain contrast-to-noise ratios (CNR) as well as the noise level in muscle. Images were analyzed regarding image quality and number of metastatic lymph nodes by two nuclear medicine physicians. Results: The highest median CNR was found for BSREM with a β of 300 and a frame duration of 2.0 min. The OSEM reconstruction had the lowest median CNR. Both the noise level and lesion SUV max decreased with increasing β. For a frame duration of 1.5 min, the median quality score was highest for β 400-500, and for a frame duration of 2.0 min the score was highest for β 300-500. There was no statistically significant difference in the number of suspected lymph node metastases between the different image series for one of the physicians, and for the other physician the number of lymph nodes differed only for one combination of image series. Conclusions: To achieve acceptable image quality at 4 MBq/kg 18 F-FCH, we propose using a β of 400-550 with a frame duration of 1.5 min. The lower β should be used if a high CNR is desired and the higher if a low noise level is important.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Radiologi och bildbehandling hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Radiology, Nuclear Medicine and Medical Imaging hsv//eng
F-FCH
Image quality
Oncology
Protocol optimization
Q.Clear

Biuppslag (personer, institutioner, konferenser, titlar ...)

Oddstig, JennyLund University,Lunds universitet,Nuklearmedicin, Malmö,Forskargrupper vid Lunds universitet,Nuclear medicine, Malmö,Lund University Research Groups,Skåne University Hospital(Swepub:lu)med-jot (författare)
Karindotter-Borgendahl, NinaSkåne University Hospital,Lund University (författare)
Almquist, HelénLund University,Lunds universitet,Klinisk fysiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Clinical Physiology (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital(Swepub:lu)extLU-691 (författare)
Zackrisson, SophiaLund University,Lunds universitet,Diagnostisk radiologi, Malmö,Forskargrupper vid Lunds universitet,Radiology Diagnostics, Malmö,Lund University Research Groups,Skåne University Hospital(Swepub:lu)smi-sza (författare)
Minarik, DavidLund University,Lunds universitet,Medicinsk strålningsfysik, Malmö,Forskargrupper vid Lunds universitet,Medical Radiation Physics, Malmö,Lund University Research Groups,Skåne University Hospital(Swepub:lu)radf-dmi (författare)
Trägårdh, ElinLund University,Lunds universitet,Nuklearmedicin, Malmö,Forskargrupper vid Lunds universitet,WCMM- Wallenberg center för molekylär medicinsk forskning,Medicinska fakulteten,Nuclear medicine, Malmö,Lund University Research Groups,WCMM-Wallenberg Centre for Molecular Medicine,Faculty of Medicine,Skåne University Hospital(Swepub:lu)klin-etr (författare)
Nuklearmedicin, MalmöForskargrupper vid Lunds universitet (creator_code:org_t)

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Ingår i:EJNMMI Physics: Springer Science and Business Media LLC6:12197-7364

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