Quantitative T-wave morphology assessment from surface ECG is linked with cardiac events risk in genotype-positive KCNH2 mutation carriers with normal QTc values

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Search: WFRF:(Rosero G) > Quantitative T-wave...

Details
MARC

Cortez, DanielLund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,University of Minnesota Masonic Children's Hospital,University of Minnesota (author)

Quantitative T-wave morphology assessment from surface ECG is linked with cardiac events risk in genotype-positive KCNH2 mutation carriers with normal QTc values

Article/chapterEnglish2019

Publisher, publication year, extent ...

2019-10-16
Wiley,2019

Numbers

LIBRIS-ID:oai:lup.lub.lu.se:8b7d4ce0-a4bc-443b-a22f-fa3ef7dd86ee
https://lup.lub.lu.se/record/8b7d4ce0-a4bc-443b-a22f-fa3ef7dd86eeURI
https://doi.org/10.1111/jce.14210DOI

Supplementary language notes

Language:English
Summary in:English

Part of subdatabase

SwePubSwePub

Classification

Subject category:art swepub-publicationtype
Subject category:ref swepub-contenttype

Notes

Introduction: Long QT syndrome (LQTS) mutation carriers have elevated the risk of cardiac events even in the absence of QTc prolongation; however, mutation penetrance in patients with normal QTc may be reflected in abnormal T-wave shape, particularly in KCNH2 mutation carriers. We aimed to assess whether the magnitude of a three-dimensional T-wave vector (TwVM) will identify KCNH2-mutation carriers with normal QTc at risk for cardiac events. Methods: Adult LQT2 patients with QTc < 460 ms in men and <470 ms in women (n = 113, age 42 ± 16 years, 43% male) were compared with genotype-negative family members (n = 1007). The TwVM was calculated using T-wave amplitudes in leads V6, II, and V2 as the square root of (TV62 + TII2 + (0.5*TV2)2). Cox regression analysis adjusted for gender and time-dependent beta-blocker use was performed to assess cardiac event (CE) risk, defined as syncope, aborted cardiac arrest, implantable cardioverter-defibrillator therapy, or sudden death. Results: Dichotomized by median of 0.30 mV, lower TwVM was associated with elevated CE risk compared to those with high TwVM (HR = 2.95, 95% CI, 1.25-6.98, P =.014) and also remained significant after including sex and time-dependent beta-blocker usage in the Cox regression analysis (HR = 2.64, 95% CI, 1.64-4.24, P <.001). However, these associations were found only in women but not in men who had low event rates. Conclusion: T-wave morphology quantified as repolarization vector magnitude using T-wave amplitudes retrieved from standard 12-lead electrocardiogram predicts cardiac events risk in LQT2 women and appears useful for risk stratification of KCNH2-mutation carriers without QTc prolongation.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kardiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cardiac and Cardiovascular Systems hsv//eng
cardiac events
long QT syndrome
T-wave vector magnitude

Added entries (persons, corporate bodies, meetings, titles ...)

Zareba, WojciechUniversity of Rochester Medical Center (author)
McNitt, ScottUniversity of Rochester Medical Center (author)
Polonsky, BronislavaUniversity of Rochester Medical Center (author)
Rosero, Spencer Z.University of Rochester Medical Center (author)
Platonov, Pyotr G.Lund University,Lunds universitet,Electrocardiology Research Group - CIEL,Forskargrupper vid Lunds universitet,Lund University Research Groups(Swepub:lu)kard-ppl (author)
KardiologiSektion II (creator_code:org_t)

Related titles

In:Journal of Cardiovascular Electrophysiology: Wiley30:12, s. 2907-29131045-38731540-8167

Internet link

Find in a library

Journal of Cardiovascular Electrophysiology (Search for host publication in LIBRIS)

To the university's database

Find more in SwePub

By the author/editor: Cortez, Daniel; Zareba, Wojciech; McNitt, Scott; Polonsky, Bronis ...; Rosero, Spencer ...; Platonov, Pyotr ...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cardiac and Card ...

Articles in the publication: Journal of Cardi ...

By the university: Lund University

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se