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  • Ayton, ScottUniversity of Melbourne,The Florey Institute of Neuroscience and Mental Health (author)

CSF ferritin in the clinicopathological progression of Alzheimer's disease and associations with APOE and inflammation biomarkers

  • Article/chapterEnglish2023

Publisher, publication year, extent ...

  • 2022-11-10
  • BMJ,2023

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:8b8d491f-57c8-4a4d-8b68-93f00f14173e
  • https://lup.lub.lu.se/record/8b8d491f-57c8-4a4d-8b68-93f00f14173eURI
  • https://doi.org/10.1136/jnnp-2022-330052DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Background: A putative role for iron in driving Alzheimer's disease (AD) progression is complicated by previously reported associations with neuroinflammation, apolipoprotein E and AD proteinopathy. To establish how iron interacts with clinicopathological features of AD and at what disease stage iron influences cognitive outcomes, we investigated the association of cerebrospinal fluid (CSF) biomarkers of iron (ferritin), inflammation (acute phase response proteins) and apolipoproteins with pathological biomarkers (CSF Aβ42/t-tau, p-tau181), clinical staging and longitudinal cognitive deterioration in subjects from the BioFINDER cohort, with replication of key results in the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort. Methods: Ferritin, acute phase response proteins (n=9) and apolipoproteins (n=6) were measured in CSF samples from BioFINDER (n=1239; 4 years cognitive follow-up) participants stratified by cognitive status (cognitively unimpaired, mild cognitive impairment, AD) and for the presence of amyloid and tangle pathology using CSF Aβ42/t-tau (A+) and p-tau181 (T+). The ferritin and apolipoprotein E associations were replicated in the ADNI (n=264) cohort. Results: In both cohorts, ferritin and apoE were elevated in A-T+ and A+T+ subjects (16%-40%), but not clinical diagnosis. Other apolipoproteins and acute phase response proteins increased with clinical diagnosis, not pathology. CSF ferritin was positively associated with p-tau181, which was mediated by apolipoprotein E. An optimised threshold of ferritin predicted cognitive deterioration in mild cognitive impairment subjects in the BioFINDER cohort, especially those people classified as A-T- and A+T-. Conclusions: CSF markers of iron and neuroinflammation have distinct associations with disease stages, while iron may be more intimately associated with apolipoprotein E and tau pathology.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Janelidze, ShorenaLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups(Swepub:lu)nkir-sje (author)
  • Kalinowski, PawelUniversity of Melbourne,The Florey Institute of Neuroscience and Mental Health (author)
  • Palmqvist, SebastianLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital(Swepub:lu)med-spa (author)
  • Belaidi, Abdel AliThe Florey Institute of Neuroscience and Mental Health,University of Melbourne (author)
  • Stomrud, ErikLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital(Swepub:lu)med-esr (author)
  • Roberts, AnneEmory University (author)
  • Roberts, BlaineEmory University (author)
  • Hansson, OskarLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups(Swepub:lu)mphy-ohn (author)
  • Bush, Ashley IanUniversity of Melbourne,The Florey Institute of Neuroscience and Mental Health (author)
  • University of MelbourneThe Florey Institute of Neuroscience and Mental Health (creator_code:org_t)

Related titles

  • In:Journal of Neurology, Neurosurgery and Psychiatry: BMJ94:3, s. 211-2190022-30501468-330X

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