Search: onr:"swepub:oai:lup.lub.lu.se:8be6ed91-fde0-42c0-8856-b5903bfbb308" >
The length of the C...
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Lowe, Michael R.
(author)
The length of the CTLA-4 microsatellite (AT)(N)-repeat affects the risk for type 1 diabetes
- Article/chapterEnglish2000
Publisher, publication year, extent ...
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2009-07-07
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Informa UK Limited,2000
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8 s.
Numbers
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LIBRIS-ID:oai:lup.lub.lu.se:8be6ed91-fde0-42c0-8856-b5903bfbb308
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https://lup.lub.lu.se/record/8be6ed91-fde0-42c0-8856-b5903bfbb308URI
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https://doi.org/10.3109/08916930008994090DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-45414URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:17013171URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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CTLA-4 is important to down-regulating T cell responses and has been implicated in type 1 (insulin dependent) diabetes mellitus in both linkage and association studies. The aim of our study was to relate the polymorphic (AT)(n) microsatellite in the 3' untranslated sequence of the CTLA-4 gene to diabetes risk. We studied 616 consecutively diagnosed 0-34 year-old Swedish patients and 502 matched controls by PCR-based genotyping to determine the length of the 3'-end (AT)(n)repeat region of the CTLA-4 gene and categorizing alleles as predominantly monomorphic short (S) or highly polymorphic (in length) long (L) alleles. The odds of type 1 diabetes of subjects with the L/L genotype was estimated to be 1.84 times that of subjects with the S/S genotype (95% CI 1.44-2.73, p=0.002). Further analysis of the long alleles, partitioned into intermediate (I) length and very long (VL) alleles, suggested that L alleles act recessively in conferring diabetes risk (p=0.0009). This study suggests that the 3'-end (AT)(n) repeat region of the CTLA-4 gene represents a recessive risk factor for type 1 diabetes.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Graham, J
(author)
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Sund, G.
(author)
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Kockum, IKarolinska Institutet
(author)
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Landin-Olsson, M.Lund University,Lunds universitet,Medicin, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)med-mla
(author)
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Schaefer, Jonathan B
(author)
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Torn, C.Lund University,Lunds universitet,Medicin, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)med-cto
(author)
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Lernmark, A.University of Washington(Swepub:lu)endo-ale
(author)
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Dahlquist, GiselaUmeå universitet,Pediatrik(Swepub:umu)gida0001
(author)
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Blohme, G
(author)
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Karolinska InstitutetMedicin, Lund
(creator_code:org_t)
Related titles
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In:Autoimmunity: Informa UK Limited32:3, s. 173-1800891-69341607-842X
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Lowe, Michael R.
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Graham, J
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Sund, G.
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Kockum, I
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Landin-Olsson, M ...
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Schaefer, Jonath ...
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Torn, C.
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Lernmark, A.
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Dahlquist, Gisel ...
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Blohme, G
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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Autoimmunity
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Lund University
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Umeå University
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Karolinska Institutet