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  • Lowe, Michael R. (author)

The length of the CTLA-4 microsatellite (AT)(N)-repeat affects the risk for type 1 diabetes

  • Article/chapterEnglish2000

Publisher, publication year, extent ...

  • 2009-07-07
  • Informa UK Limited,2000
  • 8 s.

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:8be6ed91-fde0-42c0-8856-b5903bfbb308
  • https://lup.lub.lu.se/record/8be6ed91-fde0-42c0-8856-b5903bfbb308URI
  • https://doi.org/10.3109/08916930008994090DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-45414URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:17013171URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • CTLA-4 is important to down-regulating T cell responses and has been implicated in type 1 (insulin dependent) diabetes mellitus in both linkage and association studies. The aim of our study was to relate the polymorphic (AT)(n) microsatellite in the 3' untranslated sequence of the CTLA-4 gene to diabetes risk. We studied 616 consecutively diagnosed 0-34 year-old Swedish patients and 502 matched controls by PCR-based genotyping to determine the length of the 3'-end (AT)(n)repeat region of the CTLA-4 gene and categorizing alleles as predominantly monomorphic short (S) or highly polymorphic (in length) long (L) alleles. The odds of type 1 diabetes of subjects with the L/L genotype was estimated to be 1.84 times that of subjects with the S/S genotype (95% CI 1.44-2.73, p=0.002). Further analysis of the long alleles, partitioned into intermediate (I) length and very long (VL) alleles, suggested that L alleles act recessively in conferring diabetes risk (p=0.0009). This study suggests that the 3'-end (AT)(n) repeat region of the CTLA-4 gene represents a recessive risk factor for type 1 diabetes.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Graham, J (author)
  • Sund, G. (author)
  • Kockum, IKarolinska Institutet (author)
  • Landin-Olsson, M.Lund University,Lunds universitet,Medicin, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)med-mla (author)
  • Schaefer, Jonathan B (author)
  • Torn, C.Lund University,Lunds universitet,Medicin, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)med-cto (author)
  • Lernmark, A.University of Washington(Swepub:lu)endo-ale (author)
  • Dahlquist, GiselaUmeå universitet,Pediatrik(Swepub:umu)gida0001 (author)
  • Blohme, G (author)
  • Karolinska InstitutetMedicin, Lund (creator_code:org_t)

Related titles

  • In:Autoimmunity: Informa UK Limited32:3, s. 173-1800891-69341607-842X

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