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Cardioprotection an...
Cardioprotection and lifespan extension by the natural polyamine spermidine
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Eisenberg, Tobias (author)
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Abdellatif, Mahmoud (author)
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Schroeder, Sabrina (author)
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show more...
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Primessnig, Uwe (author)
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Stekovic, Slaven (author)
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Pendl, Tobias (author)
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Harger, Alexandra (author)
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Schipke, Julia (author)
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Zimmermann, Andreas (author)
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Schmidt, Albrecht (author)
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Tong, Mingming (author)
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Ruckenstuhl, Christoph (author)
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Dammbrueck, Christopher (author)
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Gross, Angelina S. (author)
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Herbst, Viktoria (author)
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Magnes, Christoph (author)
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Trausinger, Gert (author)
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Narath, Sophie (author)
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Meinitzer, Andreas (author)
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Hu, Zehan (author)
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Kirsch, Alexander (author)
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Eller, Kathrin (author)
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Carmona-Gutierrez, Didac (author)
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- Büttner, Sabrina (author)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,University of Graz, Austria
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Pietrocola, Federico (author)
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Knittelfelder, Oskar (author)
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Schrepfer, Emilie (author)
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Rockenfeller, Patrick (author)
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Simonini, Corinna (author)
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Rahn, Alexandros (author)
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Horsch, Marion (author)
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Moreth, Kristin (author)
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Beckers, Johannes (author)
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Fuchs, Helmut (author)
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Gailus-Durner, Valerie (author)
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Neff, Frauke (author)
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Janik, Dirk (author)
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Rathkolb, Birgit (author)
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Rozman, Jan (author)
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de Angelis, Martin Hrabe (author)
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Moustafa, Tarek (author)
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Haemmerle, Guenter (author)
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Mayr, Manuel (author)
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Willeit, Peter (author)
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von Frieling-Salewsky, Marion (author)
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Pieske, Burkert (author)
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Scorrano, Luca (author)
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Pieber, Thomas (author)
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Pechlaner, Raimund (author)
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Willeit, Johann (author)
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Sigrist, Stephan J. (author)
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Linke, Wolfgang A. (author)
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Muehlfeld, Christian (author)
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Sadoshima, Junichi (author)
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Dengjel, Joern (author)
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Kiechl, Stefan (author)
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Kroemer, Guido (author)
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Sedej, Simon (author)
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Madeo, Frank (author)
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(creator_code:org_t)
- 2016-11-14
- 2016
- English.
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In: Nature Medicine. - : Springer Science and Business Media LLC. - 1078-8956 .- 1546-170X. ; 22:12, s. 1428-1438
- Related links:
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https://europepmc.or...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Aging is associated with an increased risk of cardiovascular disease and death. Here we show that oral supplementation of the natural polyamine spermidine extends the lifespan of mice and exerts cardioprotective effects, reducing cardiac hypertrophy and preserving diastolic function in old mice. Spermidine feeding enhanced cardiac autophagy, mitophagy and mitochondrial respiration, and it also improved the mechano-elastical properties of cardiomyocytes in vivo, coinciding with increased titin phosphorylation and suppressed subclinical inflammation. Spermidine feeding failed to provide cardioprotection in mice that lack the autophagy-related protein Atg5 in cardiomyocytes. In Dahl salt-sensitive rats that were fed a high-salt diet, a model for hypertension-induced congestive heart failure, spermidine feeding reduced systemic blood pressure, increased titin phosphorylation and prevented cardiac hypertrophy and a decline in diastolic function, thus delaying the progression to heart failure. In humans, high levels of dietary spermidine, as assessed from food questionnaires, correlated with reduced blood pressure and a lower incidence of cardiovascular disease. Our results suggest a new and feasible strategy for protection against cardiovascular disease.
Subject headings
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Eisenberg, Tobia ...
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Abdellatif, Mahm ...
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Schroeder, Sabri ...
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Primessnig, Uwe
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Stekovic, Slaven
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Pendl, Tobias
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show more...
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Harger, Alexandr ...
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Schipke, Julia
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Zimmermann, Andr ...
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Schmidt, Albrech ...
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Tong, Mingming
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Ruckenstuhl, Chr ...
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Dammbrueck, Chri ...
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Gross, Angelina ...
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Herbst, Viktoria
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Magnes, Christop ...
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Trausinger, Gert
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Narath, Sophie
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Meinitzer, Andre ...
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Hu, Zehan
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Kirsch, Alexande ...
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Eller, Kathrin
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Carmona-Gutierre ...
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Büttner, Sabrina
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Pietrocola, Fede ...
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Knittelfelder, O ...
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Schrepfer, Emili ...
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Rockenfeller, Pa ...
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Simonini, Corinn ...
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Rahn, Alexandros
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Horsch, Marion
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Moreth, Kristin
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Beckers, Johanne ...
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Fuchs, Helmut
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Gailus-Durner, V ...
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Neff, Frauke
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Janik, Dirk
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Rathkolb, Birgit
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Rozman, Jan
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de Angelis, Mart ...
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Moustafa, Tarek
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Haemmerle, Guent ...
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Mayr, Manuel
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Willeit, Peter
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von Frieling-Sal ...
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Pieske, Burkert
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Scorrano, Luca
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Pieber, Thomas
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Pechlaner, Raimu ...
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Willeit, Johann
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Sigrist, Stephan ...
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Linke, Wolfgang ...
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Muehlfeld, Chris ...
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Sadoshima, Junic ...
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Dengjel, Joern
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Kiechl, Stefan
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Kroemer, Guido
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Sedej, Simon
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Madeo, Frank
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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Nature Medicine
- By the university
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Stockholm University
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Karolinska Institutet