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Search: (WFRF:(Andrulis Irene L.)) srt2:(2015-2019) > (2019) > The association bet...

  • Kar, Siddhartha P.University of Cambridge (author)

The association between weight at birth and breast cancer risk revisited using Mendelian randomisation

  • Article/chapterEnglish2019

Publisher, publication year, extent ...

  • 2019-02-08
  • Springer Science and Business Media LLC,2019

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:8d406351-5fed-47a3-b49f-559536a74574
  • https://lup.lub.lu.se/record/8d406351-5fed-47a3-b49f-559536a74574URI
  • https://doi.org/10.1007/s10654-019-00485-7DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:140835876URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Observational studies suggest that higher birth weight (BW) is associated with increased risk of breast cancer in adult life. We conducted a two-sample Mendelian randomisation (MR) study to assess whether this association is causal. Sixty independent single nucleotide polymorphisms (SNPs) known to be associated at P < 5 × 10 −8 with BW were used to construct (1) a 41-SNP instrumental variable (IV) for univariable MR after removing SNPs with pleiotropic associations with other breast cancer risk factors and (2) a 49-SNP IV for multivariable MR after filtering SNPs for data availability. BW predicted by the 41-SNP IV was not associated with overall breast cancer risk in inverse-variance weighted (IVW) univariable MR analysis of genetic association data from 122,977 breast cancer cases and 105,974 controls (odds ratio = 0.86 per 500 g higher BW; 95% confidence interval 0.73–1.01). Sensitivity analyses using four alternative methods and three alternative IVs, including an IV with 59 of the 60 BW-associated SNPs, yielded similar results. Multivariable MR adjusting for the effects of the 49-SNP IV on birth length, adult height, adult body mass index, age at menarche, and age at menopause using IVW and MR-Egger methods provided estimates consistent with univariable analyses. Results were also similar when all analyses were repeated after restricting to estrogen receptor-positive or -negative breast cancer cases. Point estimates of the odds ratios from most analyses performed indicated an inverse relationship between genetically-predicted BW and breast cancer, but we are unable to rule out an association between the non-genetically-determined component of BW and breast cancer. Thus, genetically-predicted higher BW was not associated with an increased risk of breast cancer in adult life in our MR study.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Andrulis, Irene L.University of Toronto,Mount Sinai Hospital of University of Toronto (author)
  • Brenner, HermannNational Centre of Tumor Diseases,German Cancer Research Centre (author)
  • Burgess, StephenUniversity of Cambridge (author)
  • Chang-Claude, JennyGerman Cancer Research Centre,University Medical Center Hamburg-Eppendorf (author)
  • Considine, DanielUniversity of Cambridge (author)
  • Dörk, ThiloHannover Medical School (author)
  • Evans, Dafydd Gareth R.University of Manchester (author)
  • Gago-Domínguez, ManuelaUniversity of California, San Diego,Complejo Hospitalario Universitario de Santiago,University of Santiago de Compostela (author)
  • Giles, Graham G.University of Melbourne,Cancer Council Victoria (author)
  • Hartman, MikaelNational University of Singapore (author)
  • Huo, DezhengUniversity of Chicago (author)
  • Kaaks, RudolfGerman Cancer Research Centre (author)
  • Li, JingmeiA*Star, Genome Institute of Singapore (GIS) (author)
  • Lophatananon, ArtitayaUniversity of Manchester (author)
  • Margolin, SaraKarolinska Institutet,Karolinska Institute,Stockholm South General Hospital (author)
  • Milne, Roger L.University of Melbourne,Cancer Council Victoria (author)
  • Muir, Kenneth R.University of Manchester (author)
  • Olsson, HåkanLund University,Lunds universitet,Lunds Melanomstudiegrupp,Forskargrupper vid Lunds universitet,Lund Melanoma Study Group,Lund University Research Groups(Swepub:lu)onk-hol (author)
  • Punie, KevinCatholic University of Leuven,University Hospitals Leuven (author)
  • Radice, PaoloIstituto Nazionale dei Tumori (author)
  • Simard, JacquesCentre hospitalier universitaire de Québec,Laval University (author)
  • Tamimi, Rulla M.Harvard University,Brigham and Women's Hospital / Harvard Medical School (author)
  • Van Nieuwenhuysen, ElsCatholic University of Leuven,University Hospitals Leuven (author)
  • Wendt, CamillaKarolinska Institute,Stockholm South General Hospital (author)
  • Zheng, WeiVanderbilt University (author)
  • Pharoah, Paul D.P.University of Cambridge (author)
  • University of CambridgeUniversity of Toronto (creator_code:org_t)

Related titles

  • In:European Journal of Epidemiology: Springer Science and Business Media LLC34:6, s. 591-6000393-29901573-7284

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