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Pleiotropy of genet...
Pleiotropy of genetic variants on obesity and smoking phenotypes : Results from the Oncoarray Project of The International Lung Cancer Consortium
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- Wang, Tao (author)
- Yeshiva University
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- Moon, Jee Young (author)
- Yeshiva University
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- Wu, Yiqun (author)
- Yeshiva University,Peking University
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- Amos, Christopher I. (author)
- Dartmouth College
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- Hung, Rayjean J. (author)
- University of Toronto
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- Tardon, Adonina (author)
- CIBER Epidemiology and Public Health (CIBERESP),University of Oviedo
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- Andrew, Angeline (author)
- Norris Cotton Cancer Center,Radboud University Nijmegen
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- Chen, Chu (author)
- Fred Hutchinson Cancer Research Center,Harvard University,Vanderbilt University
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- Christiani, David C. (author)
- Harvard University
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- Albanes, Demetrios (author)
- National Cancer Institute, USA
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- Heijden, Erik H.F.M.van der (author)
- Radboud University Nijmegen
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- Duell, Eric (author)
- Catalan Institute of Oncology
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- Rennert, Gadi (author)
- Carmel Medical Center
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- Goodman, Gary (author)
- Fred Hutchinson Cancer Research Center
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- Liu, Geoffrey (author)
- University of Toronto
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- Mckay, James D. (author)
- International Agency for Research on Cancer, World Health Organization
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- Yuan, Jian Min (author)
- University of Pittsburgh
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- Field, John K. (author)
- University of Liverpool
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- Manjer, Jonas (author)
- Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups,Skåne University Hospital
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- Grankvist, Kjell (author)
- Umeå universitet,Umeå University,Klinisk kemi
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- Kiemeney, Lambertus A. (author)
- Radboud University Nijmegen
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- Marchand, Loic Le (author)
- University of Hawai'i at Hilo
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- Teare, M. Dawn (author)
- University of Sheffield
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- Schabath, Matthew B. (author)
- H. Lee Moffitt Cancer Center & Research Institute
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- Johansson, Mattias (author)
- International Agency for Research on Cancer, World Health Organization
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- Aldrich, Melinda C. (author)
- Vanderbilt University
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- Davies, Michael (author)
- University of Liverpool
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- Johansson, Mikael (author)
- Umeå universitet,Umeå University,Onkologi
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- Tsao, Ming Sound (author)
- Princess Margaret Hospital University of Toronto
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- Caporaso, Neil (author)
- National Cancer Institute, USA
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- Lazarus, Philip (author)
- Washington State University
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- Lam, Stephen (author)
- British Columbia Cancer Agency
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- Bojesen, Stig E. (author)
- Copenhagen University Hospital,University of Copenhagen
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- Arnold, Susanne (author)
- University of Kentucky
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- Wu, Xifeng (author)
- University of Texas
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- Zong, Xuchen (author)
- University of Toronto
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- Hong, Yun Chul (author)
- Seoul National University
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- Ho, Gloria Y.F. (author)
- Hofstra University
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(creator_code:org_t)
- 2017-09-28
- 2017
- English.
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In: PLoS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 12:9, s. 0185660-0185660
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https://journals.plo...
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- Obesity and cigarette smoking are correlated through complex relationships. Common genetic causes may contribute to these correlations. In this study, we selected 241 loci potentially associated with body mass index (BMI) based on the Genetic Investigation of ANthropometric Traits (GIANT) consortium data and calculated a BMI genetic risk score (BMI-GRS) for 17,037 individuals of European descent from the Oncoarray Project of the International Lung Cancer Consortium (ILCCO). Smokers had a significantly higher BMI-GRS than never-smokers (p = 0.016 and 0.010 before and after adjustment for BMI, respectively). The BMI-GRS was also positively correlated with pack-years of smoking (p<0.001) in smokers. Based on causal network inference analyses, seven and five of 241 SNPs were classified to pleiotropic models for BMI/smoking status and BMI/pack-years, respectively. Among them, three and four SNPs associated with smoking status and pack-years (p<0.05), respectively, were followed up in the ever-smoking data of the Tobacco, Alcohol and Genetics (TAG) consortium. Among these seven candidate SNPs, one SNP (rs11030104, BDNF) achieved statistical significance after Bonferroni correction for multiple testing, and three suggestive SNPs (rs13021737, TMEM18; rs11583200, ELAVL4; and rs6990042, SGCZ) achieved a nominal statistical significance. Our results suggest that there is a common genetic component between BMI and smoking, and pleiotropy analysis can be useful to identify novel genetic loci of complex phenotypes.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
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- art (subject category)
- ref (subject category)
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- By the author/editor
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Wang, Tao
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Moon, Jee Young
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Wu, Yiqun
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Amos, Christophe ...
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Hung, Rayjean J.
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Tardon, Adonina
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show more...
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Andrew, Angeline
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Chen, Chu
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Christiani, Davi ...
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Albanes, Demetri ...
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Heijden, Erik H. ...
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Duell, Eric
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Rennert, Gadi
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Goodman, Gary
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Liu, Geoffrey
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Mckay, James D.
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Yuan, Jian Min
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Field, John K.
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Manjer, Jonas
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Grankvist, Kjell
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Kiemeney, Lamber ...
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Marchand, Loic L ...
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Teare, M. Dawn
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Schabath, Matthe ...
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Johansson, Matti ...
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Aldrich, Melinda ...
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Davies, Michael
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Johansson, Mikae ...
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Tsao, Ming Sound
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Caporaso, Neil
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Lazarus, Philip
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Lam, Stephen
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Bojesen, Stig E.
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Arnold, Susanne
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Wu, Xifeng
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Zong, Xuchen
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Hong, Yun Chul
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Ho, Gloria Y.F.
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
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PLoS ONE
- By the university
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Lund University
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Umeå University