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Irestorm, ElinLund University,Lunds universitet,Pediatrisk onkologi,Forskargrupper vid Lunds universitet,Childhood Cancer Research Unit,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Pediatric Oncology,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Princess Maxima Center for Pediatric Oncology/Hematology
(author)
The development of fatigue after treatment for pediatric brain tumors does not differ between tumor locations
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LIBRIS-ID:oai:lup.lub.lu.se:8d8b1adf-60ea-4aab-a9da-3c582dff58dd
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https://lup.lub.lu.se/record/8d8b1adf-60ea-4aab-a9da-3c582dff58ddURI
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https://doi.org/10.1002/pbc.31028DOI
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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BackgroundChildren and adolescents treated for a brain tumor suffer from more fatigue than survivors of other types of childhood cancer. As tumor location might be predictive of fatigue, our aim was to investigate the longitudinal development of fatigue in children with brain tumors and risk factors for fatigue separately for different tumor locations.MethodsFatigue was assessed 1235 times for 425 participants. Self-report versions of PedsQL Multidimensional Fatigue Scale were used to repeatedly assess fatigue from the end of treatment up to 8 years later. Mixed models were used to analyze fatigue over time and determinants separately for infratentorial (N = 205), supratentorial hemispheric (N = 91), and supratentorial midline tumors (N = 129).ResultsCognitive fatigue worsened with time, while sleep-rest and general fatigue first decreased and then increased. There was no difference in fatigue between the tumor locations, but the risk factors differed when stratified by location. Radiotherapy was associated with more fatigue for infratentorial tumors, and centralization of care was associated with less fatigue for the supratentorial midline tumors. For supratentorial hemispheric tumors, female sex was associated with more fatigue. Higher parental education was associated with less fatigue regardless of tumor location.ConclusionsThe development of fatigue seems to be more related to sociodemographic and treatment variables than to tumor location. Healthcare providers need to be aware that fatigue may develop in the years following end of treatment, and that patients with a low/middle educational family background might be more vulnerable and in need of targeted support.
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Meeteren, Antoinette Y N Schouten vanPrincess Maxima Center for Pediatric Oncology/Hematology
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van Gorp, MarloesPrincess Maxima Center for Pediatric Oncology/Hematology
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Twisk, Jos W RAmsterdam Public Health
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Van Santen, Hanneke M.Wilhelmina Children’s Hospital
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Partanen, MaritaPrincess Maxima Center for Pediatric Oncology/Hematology
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Grootenhuis, Martha A.Princess Maxima Center for Pediatric Oncology/Hematology
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van Litsenburg, Raphaele R.L.Princess Maxima Center for Pediatric Oncology/Hematology
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Pediatrisk onkologiForskargrupper vid Lunds universitet
(creator_code:org_t)
Related titles
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In:Pediatric Blood & Cancer, s. 1-91545-5017
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