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  • Sjögreen Gleisner, KatarinaLund University,Lunds universitet,Nuclear Medicine Physics,Forskargrupper vid Lunds universitet,Lund University Research Groups,Lund Univ, Dept Med Radiat Phys, Clin Sci Lund, Lund, Sweden. (författare)

Variations in the practice of molecular radiotherapy and implementation of dosimetry : results from a European survey

  • Artikel/kapitelEngelska2017

Förlag, utgivningsår, omfång ...

  • 2017-12-04
  • Springer Science and Business Media LLC,2017

Nummerbeteckningar

  • LIBRIS-ID:oai:lup.lub.lu.se:8d8e608b-0e65-4d99-94bb-c42ccce30732
  • https://lup.lub.lu.se/record/8d8e608b-0e65-4d99-94bb-c42ccce30732URI
  • https://doi.org/10.1186/s40658-017-0193-4DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-343903URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype

Anmärkningar

  • Background: Currently, the implementation of dosimetry in molecular radiotherapy (MRT) is not well investigated, and in view of the Council Directive (2013/59/Euratom), there is a need to understand the current availability of dosimetry-based MRT in clinical practice and research studies. The aim of this study was to assess the current practice of MRT and dosimetry across European countries. Methods: An electronic questionnaire was distributed to European countries. This addressed 18 explicitly considered therapies, and for each therapy, a similar set of questions were included. Questions covered the number of patients and treatments during 2015, involvement of medical specialties and medical physicists, implementation of absorbed dose planning, post-therapy imaging and dosimetry, and the basis of therapy prescription. Results: Responses were obtained from 26 countries and 208 hospitals, administering in total 42,853 treatments. The most common therapies were 131I-NaI for benign thyroid diseases and thyroid ablation of adults. The involvement of a medical physicist (mean over all 18 therapies) was reported to be either minority or never by 32% of the responders. The percentage of responders that reported that dosimetry was included on an always/majority basis differed between the therapies and showed a median value of 36%. The highest percentages were obtained for 177Lu-PSMA therapy (100%), 90Y microspheres of glass (84%) and resin (82%), 131I-mIBG for neuroblastoma (59%), and 131I-NaI for benign thyroid diseases (54%). The majority of therapies were prescribed based on fixed-activity protocols. The highest number of absorbed-dose based prescriptions were reported for 90Y microsphere treatments in the liver (64% and 96% of responses for resin and glass, respectively), 131I-NaI treatment of benign thyroid diseases (38% of responses), and for 131I-mIBG treatment of neuroblastoma (18% of responses). Conclusions: There is a wide variation in MRT practice across Europe and for different therapies, including the extent of medical-physicist involvement and the implementation of dosimetry-guided treatments.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Spezi, EmilianoCardiff University,Cardiff Univ, Sch Engn, Cardiff, S Glam, Wales. (författare)
  • Solny, PavelUniversity Hospital Motol,Charles Univ Prague, Motol Univ Hosp, Dept Nucl Med & Endocrinol, Fac Med 2, Prague, Czech Republic. (författare)
  • Gabina, Pablo MinguezGurutzeta/Cruces University Hospital,Gurutzeta Cruces Univ Hosp, Dept Med Phys & Radiat Protect, Baracaldo, Spain.(Swepub:lu)pa5002mi (författare)
  • Cicone, FrancescoSapienza University of Rome,Sapienza Univ Rome, Dept Surg & Med Sci & Translat Med, St Andrea Hosp, Nucl Med, Rome, Italy. (författare)
  • Stokke, CarolineOslo university hospital,Oslo Univ Hosp, Dept Diagnost Phys, Oslo, Norway. (författare)
  • Chiesa, CarloIstituto Nazionale dei Tumori,Fdn IRCCS Ist Nazl Tumori, Div Nucl Med, Milan, Italy. (författare)
  • Paphiti, MariaPammakaristos Hospital,Pammakaristos Hosp, Dept Med Phys, Athens, Greece. (författare)
  • Brans, BoudewijnGhent University Hospital,Univ Hosp, Dept Nucl Med, Ghent, Belgium.;Univ Hosp, PET Ctr, Ghent, Belgium. (författare)
  • Sandström, MattiasUppsala universitet,Radiologi(Swepub:uu)masan637 (författare)
  • Tipping, JillChristie NHS Foundation Trust,Christie NHS Fdn Trust, Nucl Med, Manchester, Lancs, England. (författare)
  • Konijnenberg, MarkErasmus University Medical Center,Erasmus MC, Dept Nucl Med, Rotterdam, Netherlands. (författare)
  • Flux, GlennInstitute of Cancer Research London,Royal Marsden Hosp, Dept Phys, Sutton, Surrey, England.;Inst Canc Res, Sutton, Surrey, England. (författare)
  • Nuclear Medicine PhysicsForskargrupper vid Lunds universitet (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:EJNMMI Physics: Springer Science and Business Media LLC4:12197-7364

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