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Quantitative proteo...
Quantitative proteomic analysis identifies proteins and pathways related to neuronal development in differentiated SH-SY5Y neuroblastoma cells
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- Murillo, Jimmy Rodriguez (författare)
- Federal University of Rio de Janeiro
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- Goto-Silva, Livia (författare)
- D'Or Institute for Research and Education
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- Sánchez, Aniel (författare)
- Lund University,Lunds universitet,Clinical Protein Science and Imaging,Forskargrupper vid Lunds universitet,Lund University Research Groups,Skåne University Hospital
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- Nogueira, Fábio C.S. (författare)
- Federal University of Rio de Janeiro
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- Domont, Gilberto B. (författare)
- Federal University of Rio de Janeiro
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- Junqueira, Magno (författare)
- Federal University of Rio de Janeiro
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(creator_code:org_t)
- Elsevier BV, 2017
- 2017
- Engelska 11 s.
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Ingår i: EuPA Open Proteomics. - : Elsevier BV. - 2212-9685. ; 16, s. 1-11
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- SH-SY5Y neuroblastoma cells are susceptible to differentiation using retinoic acid (RA) and brain-derived neurotrophic factor (BDNF), providing a model of neuronal differentiation. We compared SH-SY5Y cells proteome before and after RA/BDNF treatment using iTRAQ and phosphopeptide enrichment strategies. We identified 5587 proteins, 366 of them with differential abundance. Differentiated cells expressed proteins related to neuronal development, and, undifferentiated cells expressed proteins involved in cell proliferation. Interactive network covered focal adhesion, cytoskeleton dynamics and neurodegenerative diseases processes and regulation of mitogen-activated protein kinase-related signaling pathways; key proteins involved in those processes might be explored as markers for neuronal differentiation.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- iTRAQ-based proteomics
- Neuronal differentiation
- Phosphoproteomics
- SH-SY5Y cells
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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