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Platelet function t...
Platelet function testing : Current practice among clinical centres in Northern Europe
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- Szanto, Timea (author)
- Helsinki University Central Hospital,Coagulation Disorders Unit, Department of Hematology, Comprehensive Cancer Center, Helsinki University Hospital, Helsinki, Finland; Research Program in Systems Oncology, Helsinki University, Helsinki, Finland,Helsinki Univ Hosp, Finland; Univ Helsinki, Finland
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- Zetterberg, Eva (author)
- Lund University,Lunds universitet,Klinisk koagulationsmedicin, Malmö,Forskargrupper vid Lunds universitet,Clinical Coagulation, Malmö,Lund University Research Groups,Department of Translational Medicine & Centre for Thrombosis and Haemostasis, Lund University, Malmö, Sweden,Lund Univ, Sweden; Lund Univ, Sweden
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- Ramström, Sofia, 1973- (author)
- Linköpings universitet,Örebro universitet,Örebro University,Linköping University,Institutionen för medicinska vetenskaper,Department of Clinical Chemistry and Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden,Avdelningen för klinisk kemi och farmakologi,Medicinska fakulteten,Region Östergötland, Klinisk kemi,Orebro Univ, Sweden
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- Leinøe, Eva B. (author)
- Department of Haematology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark,Copenhagen Univ Hosp, Denmark
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- Holme, Pål A. (author)
- Department of Haematology, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway,Univ Oslo, Norway; Univ Oslo, Norway
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- Antovic, Jovan P. (author)
- Karolinska Institutet
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- Holmström, Margareta (author)
- Linköpings universitet,Linköping University,Department of Health and Department of Acute Internal Medicine and Geriatrics, Medicine and Caring Sciences Linköping University, Linköping, Sweden,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Medicinska och geriatriska akutkliniken
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- Onundarson, Pall T. (author)
- Faculty of Medicine, University of Iceland, Reykjavik, Iceland,Univ Iceland, Iceland
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- Pikta, Marika (author)
- Laboratory, North Estonia Medical Centre, Tallinn, Estonia,North Estonia Med Ctr, Estonia
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- Vaide, Ines (author)
- Department of Hemato-Oncology, University of Tartu, Institute of Clinical Medicine, Tartu, Estonia,Univ Tartu, Estonia
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- Olsson, Anna (author)
- Region Västra Götaland, Department of Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden,The County of Västra Götaland,Sahlgrens Univ Hosp, Sweden
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- Magnusson, Maria (author)
- Karolinska Institutet
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- Kärkkäinen, Satu (author)
- Hemostasis and Platelet Laboratory, Fimlab Laboratoriot, Tampere, Finland,Fimlab Lab, Finland
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- Bitar, Manar (author)
- Department of Laboratory Medicine, Clinical Chemistry, Faculty of Medicine and Health, Örebro University Hospital, Örebro, Sweden,Orebro Univ Hosp, Sweden
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- Poulsen, Lone Hvitfeldt (author)
- Centre for Haemophilia and Thrombosis, Aarhus University Hospital, Aarhus, Denmark,Aarhus Univ Hosp, Denmark
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- Lassila, Riitta (author)
- Helsinki University Central Hospital,Coagulation Disorders Unit, Department of Hematology, Comprehensive Cancer Center, Helsinki University Hospital, Helsinki, Finland; Research Program in Systems Oncology, Helsinki University, Helsinki, Finland,Helsinki Univ Hosp, Finland; Univ Helsinki, Finland
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(creator_code:org_t)
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- 2022-05-05
- 2022
- English.
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In: Haemophilia. - : Wiley. - 1351-8216 .- 1365-2516. ; 28:4, s. 642-648
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Abstract
Subject headings
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- Introduction: Platelet function tests are used to screen and diagnose patients with possible inherited platelet function defects (IPFD). Some acquired platelet dysfunction may be caused by certain drugs or comorbidities, which need to be excluded before testing. Aims: To identify current practice among centres performing platelet function tests in Northern Europe. Methods: A total of 14 clinical centres from Sweden (six), Finland (two), Denmark (two), Norway (one), Estonia (two) and Iceland (one) completed the survey questionnaire, the population capture area of about 29.5 million. Results: Six of the 14 (42.8%) centres providing platelet function assessment represent comprehensive treatment centres (EUHANET status). A Bleeding score (BS) or ISTH bleeding assessment tool (ISTH BAT score) is evaluated in 11/14 (78.6%) centres and family history in all. Five/14 centres (35.7%) use structured preanalytical patient instructions, and 10/14 (71.4%) recorded questionnaire on the preassessment of avoidance of any drugs or natural products affecting platelet functions. Preliminary investigations of screening tests of coagulation are performed in 10/14 (71.4%), while in 4/14 (28.6%), the diagnostic work-up of IPFD and von Willebrand disease (VWD) is performed simultaneously. The work-up of IPFD includes peripheral blood smear in 10/14 (71.4%), platelet aggregometry in all, flow cytometry in 10/14 (71.4%) and Platelet Function Analysis (PFA) in 3/11 (28.6%). Molecular genetic diagnosis is available in 7/14 (50%) centres. Conclusions: The considerable variability in the current practice illustrates the need for harmonization between the Northern European centres according to the international registers (i.e. EUHASS) and IPFD guidelines (ISTH, EHA).
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Allmänmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- General Practice (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- blood platelet disorders
- data collection
- platelet function testing
- platelets
- survey
- Blood platelet disorders
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Szanto, Timea
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Zetterberg, Eva
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Ramström, Sofia, ...
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Leinøe, Eva B.
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Holme, Pål A.
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Antovic, Jovan P ...
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show more...
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Holmström, Marga ...
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Onundarson, Pall ...
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Pikta, Marika
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Vaide, Ines
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Olsson, Anna
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Magnusson, Maria
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Kärkkäinen, Satu
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Bitar, Manar
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Poulsen, Lone Hv ...
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Lassila, Riitta
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and General Practice
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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Haemophilia
- By the university
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Lund University
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Örebro University
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Linköping University
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Karolinska Institutet