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Prediagnostic calci...
Prediagnostic calcium intake and lung cancer survival : A pooled analysis of 12 cohort studies
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- Yu, Danxia (author)
- Vanderbilt University
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- Takata, Yumie (author)
- Oregon State University,Vanderbilt University
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- Smith-Warner, Stephanie A. (author)
- Harvard University
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- Blot, William (author)
- Vanderbilt University
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- Sawada, Norie (author)
- National Cancer Center Tokyo
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- White, Emily (author)
- Fred Hutchinson Cancer Research Center
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- Freedman, Neal (author)
- National Cancer Institute, USA
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- Robien, Kim (author)
- George Washington University
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- Giovannucci, Edward (author)
- Harvard University
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- Zhang, Xuehong (author)
- Brigham and Women's Hospital / Harvard Medical School
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- Park, Yikyung (author)
- Washington University in St. Louis
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- Gao, Yu-Tang (author)
- Renji Hospital
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- Chlebowski, Rowan T. (author)
- University of California, Los Angeles
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- Langhammer, Arnulf (author)
- Norwegian University of Science and Technology
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- Yang, Gong (author)
- Vanderbilt University,Renji Hospital
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- Severi, Gianluca (author)
- University of Melbourne,Human Genetics Foundation (HuGeF),University of Paris-Saclay,Stabilite genetique et oncogenese
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- Manjer, Jonas (author)
- Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups
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- Khaw, Kay Tee (author)
- University of Cambridge
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- Weiderpass, Elisabete (author)
- Karolinska Institutet,Karolinska Institute,Folkhälsan Research Center,UiT The Arctic University of Norway, Tromsø,Cancer Registry of Norway, Institute of Population-Based Cancer Research
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- Liao, Linda M. (author)
- National Cancer Institute, USA
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- Caporaso, Neil E (author)
- National Cancer Institute, USA
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- Krokstad, Steinar (author)
- Norwegian University of Science and Technology
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- Hveem, Kristian (author)
- Norwegian University of Science and Technology
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- Sinha, Rashmi (author)
- National Cancer Institute, USA
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- Ziegler, Regina G. (author)
- National Cancer Institute, USA
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- Tsugane, Shoichiro (author)
- National Cancer Center Tokyo
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- Xiang, Yong-Bing (author)
- Renji Hospital
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- Johansson, Mattias (author)
- International Agency for Research on Cancer, World Health Organization
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- Zheng, Wei (author)
- Vanderbilt University
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- Shu, Xiao-Ou (author)
- Vanderbilt University
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(creator_code:org_t)
- 2017
- 2017
- English 11 s.
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In: Cancer Epidemiology Biomarkers and Prevention. - 1055-9965. ; 26:7, s. 1060-1070
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Background: Lung cancer is the leading cause of cancer death. Little is known about whether prediagnostic nutritional factors may affect survival. We examined the associations of prediagnostic calcium intake from foods and/or supplements with lung cancer survival. Methods: The present analysis included 23,882 incident, primary lung cancer patients from 12 prospective cohort studies. Dietary calcium intake was assessed using food-frequency questionnaires at baseline in each cohort and standardized to caloric intake of 2,000 kcal/d for women and 2,500 kcal/d for men. Stratified, multivariable-adjusted Cox regression was applied to compute hazard ratios (HR) and 95% confidence intervals (CI). Results: The 5-year survival rates were 56%, 21%, and 5.7% for localized, regional, and distant stage lung cancer, respectively. Low prediagnostic dietary calcium intake (<500-600 mg/d, less than half of the recommendation) was associated with a small increase in risk of death compared with recommended calcium intakes (800-1,200 mg/d); HR (95% CI) was 1.07 (1.01-1.13) after adjusting for age, stage, histology, grade, smoking status, pack-years, and other potential prognostic factors. The association between low calcium intake and higher lung cancer mortality was evident primarily among localized/regional stage patients, with HR (95% CI) of 1.15 (1.04-1.27). No association was found for supplemental calcium with survival in the multivariable-adjusted model. Conclusions: This large pooled analysis is the first, to our knowledge, to indicate that low prediagnostic dietary calcium intake may be associated with poorer survival among early-stage lung cancer patients. Impact: This multinational prospective study linked low calcium intake to lung cancer prognosis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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- art (subject category)
- ref (subject category)
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- By the author/editor
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Yu, Danxia
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Takata, Yumie
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Smith-Warner, St ...
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Blot, William
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Sawada, Norie
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White, Emily
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show more...
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Freedman, Neal
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Robien, Kim
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Giovannucci, Edw ...
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Zhang, Xuehong
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Park, Yikyung
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Gao, Yu-Tang
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Chlebowski, Rowa ...
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Langhammer, Arnu ...
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Yang, Gong
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Severi, Gianluca
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Manjer, Jonas
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Khaw, Kay Tee
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Weiderpass, Elis ...
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Liao, Linda M.
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Caporaso, Neil E
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Krokstad, Steina ...
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Hveem, Kristian
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Sinha, Rashmi
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Ziegler, Regina ...
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Tsugane, Shoichi ...
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Xiang, Yong-Bing
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Johansson, Matti ...
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Zheng, Wei
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Shu, Xiao-Ou
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Cancer Epidemiol ...
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Cancer epidemiol ...
- By the university
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Lund University
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Karolinska Institutet