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Sökning: WFRF:(Kuehni C. E.) > (2020-2024) > Cumulative Absolute...

  • Heymer, Emma J.University of Birmingham (författare)

Cumulative Absolute Risk of Subsequent Colorectal Cancer After Abdominopelvic Radiotherapy Among Childhood Cancer Survivors : A PanCareSurFup Study

  • Artikel/kapitelEngelska2024

Förlag, utgivningsår, omfång ...

  • 2024
  • 12 s.

Nummerbeteckningar

  • LIBRIS-ID:oai:lup.lub.lu.se:8fa0e5c7-3d8e-4015-9900-3631b13a0ccb
  • https://lup.lub.lu.se/record/8fa0e5c7-3d8e-4015-9900-3631b13a0ccbURI
  • https://doi.org/10.1200/JCO.23.00452DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:237972325URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:158410077URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype

Anmärkningar

  • PURPOSE Childhood cancer survivors are at the risk of developing subsequent colorectal cancers (CRCs), but the absolute risks by treatment modality are uncertain. We quantified the absolute risks by radiotherapy treatment characteristics using clinically accessible data from a Pan-European wide case-control study nested within a large cohort of childhood cancer survivors: the PanCareSurFup Study. METHODS Odds ratios (ORs) from a case-control study comprising 143 CRC cases and 143 controls nested within a cohort of 69,460 survivors were calculated. These, together with standardized incidence ratios for CRC for this cohort and European general population CRC incidence rates and survivors' mortality rates, were used to estimate cumulative absolute risks (CARs) by attained age for different categories of radiation to the abdominopelvic area. RESULTS Overall, survivors treated with abdominopelvic radiotherapy treatment (ART) were three times more likely to develop a subsequent CRC than those who did not receive ART (OR, 3.1 [95% CI, 1.4 to 6.6]). For male survivors treated with ART, the CAR was 0.27% (95% CI, 0.17 to 0.59) by age 40 years, 1.08% (95% CI, 0.69 to 2.34) by age 50 years (0.27% expected in the general population), and 3.7% (95% CI, 2.36 to 7.80) by age 60 years (0.95% expected). For female survivors treated with ART, the CAR was 0.29% (95% CI, 0.18 to 0.62) by age 40 years, 1.03% (95% CI, 0.65 to 2.22) by age 50 years (0.27% expected), and 3.0% (95% CI, 1.91 to 6.37) by age 60 years (0.82% expected). CONCLUSION We demonstrated that by age 40 years survivors of childhood cancer treated with ART already have a similar risk of CRC as those age 50 years in the general population for whom population-based CRC screening begins in many countries. This information should be used in the development of survivorship guidelines for the risk stratification of survivors concerning CRC risk.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Jóźwiak, Katarzyna (författare)
  • Kremer, Leontien C.Academic Medical Center of University of Amsterdam (AMC),Princess Maxima Center for Pediatric Oncology/Hematology (författare)
  • Winter, David L.University of Birmingham (författare)
  • de Vathaire, FlorentCentre for Research in Epidemiology and Population Health (CESP) (författare)
  • Sunguc, CerenUniversity of Birmingham (författare)
  • Sugden, ElaineUniversity of Birmingham (författare)
  • Kok, Judith L.Princess Maxima Center for Pediatric Oncology/Hematology (författare)
  • van der Pal, Helena J.H.Princess Maxima Center for Pediatric Oncology/Hematology (författare)
  • Hjorth, LarsLund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Sena effekter efter barncancerbehandling,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Late effects after childhood cancer treatment,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital(Swepub:lu)pedi-lhj (författare)
  • Jakab, ZsuzsannaSemmelweis University (författare)
  • Maule, Milena M.Karolinska Institutet (författare)
  • Haupt, RiccardoGaslini Children's Hospital (författare)
  • Bagnasco, FrancescaGaslini Children's Hospital (författare)
  • Terenziani, MonicaIstituto Nazionale dei Tumori (författare)
  • Diallo, IbrahimaCentre for Research in Epidemiology and Population Health (CESP) (författare)
  • Gunnes, Maria W.Cancer Registry of Norway, Institute of Population-Based Cancer Research,Norwegian Radium Hospital (författare)
  • Sommer, GritUniversity of Bern (författare)
  • Zaletel, Lorna ZadravecInstitute of Oncology, Ljubljana (författare)
  • Kuehni, Claudia E.University of Bern,University Children's Hospital Bern (författare)
  • Winther, Jeanette F.Aarhus University Hospital,Danish Cancer Society (författare)
  • Lähteenmäki, Päivi M.Turku University Hospital (författare)
  • Gudmundsdottir, ThorgerdurNational University Hospital of Iceland,Danish Cancer Society (författare)
  • Allodji, Rodrigue S.Centre for Research in Epidemiology and Population Health (CESP) (författare)
  • Skinner, RoderickUniversity of Newcastle upon Tyne (författare)
  • Ronckers, Cécile M.Princess Maxima Center for Pediatric Oncology/Hematology,Carl von Ossietzky University of Oldenburg (författare)
  • Hawkins, Michael M.University of Birmingham (författare)
  • Reulen, Raoul C.University of Birmingham (författare)
  • Teepen, Jop C.Princess Maxima Center for Pediatric Oncology/Hematology (författare)
  • University of BirminghamAcademic Medical Center of University of Amsterdam (AMC) (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Journal of Clinical Oncology42:3, s. 336-3470732-183X
  • Ingår i:Journal of clinical oncology : official journal of the American Society of Clinical Oncology42:3, s. 336-3471527-7755

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