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Fetal/neonatal allo...
Fetal/neonatal alloimmune thrombocytopenia : A systematic review of impact of HLA-DRB3∗01:01 on fetal/neonatal outcome
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- Kjeldsen-Kragh, Jens (författare)
- Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine,University Hospital of North Norway
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- Fergusson, Dean A. (författare)
- University of Ottawa,Ottawa Hospital Research Institute
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- Kjaer, Mette (författare)
- Finnmark Hospital Trust,UiT The Arctic University of Norway, Tromsø,University Hospital of North Norway
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- Lieberman, Lani (författare)
- University Health Network University of Toronto,University of Toronto
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- Greinacher, Andreas (författare)
- University Medicine Greifswald
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- Murphy, Michael F. (författare)
- Oxford University Hospitals NHS Foundation Trust,University of Oxford,International Blood Group Reference Laboratory
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- Bussel, James (författare)
- New York Presbyterian Hospital/Columbia University Medical Center
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- Bakchoul, Tamam (författare)
- University of Tübingen
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- Corke, Stacy (författare)
- Naitbabies.org
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- Bertrand, Gérald (författare)
- French Blood Services of Brittany
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- Oepkes, Dick (författare)
- Leiden University Medical Centre
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- Baker, Jillian M. (författare)
- Hospital for Sick Children, Toronto,Saint Michael's Hospital
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- Hume, Heather (författare)
- Centre Hospitalier Universitaire Sainte-Justine
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- Massey, Edwin (författare)
- National Health Service Blood and Transplant
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- Kaplan, Cecile (författare)
- McMaster University
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- Arnold, Donald M. (författare)
- McMaster University
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- Baidya, Shoma (författare)
- Australian Red Cross
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- Ryan, Greg (författare)
- University of Toronto,Mount Sinai Hospital of University of Toronto
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- Savoia, Helen F. (författare)
- Royal Children's Hospital, Melbourne
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- Landry, Denise (författare)
- Canadian Blood Services
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- Shehata, Nadine (författare)
- University of Toronto
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(creator_code:org_t)
- 2020-07-27
- 2020
- Engelska 10 s.
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Ingår i: Blood Advances. - : American Society of Hematology. - 2473-9529 .- 2473-9537. ; 4:14, s. 3368-3377
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The most common, severe cases of fetal and neonatal alloimmune thrombocytopenia among whites are caused by antibodies against human platelet antigen 1a (HPA-1a). The aims of this systematic review and meta-analysis are to determine the association between maternal HLA-DRB3∗01:01 and: (1) HPA-1a-alloimmunization and (2) neonatal outcome in children born of HPA-1a-immunized women. A systematic literature search identified 4 prospective and 8 retrospective studies. Data were combined across studies to estimate pooled odds ratios (ORs) and the associated 95% confidence intervals (CIs). The population represented by the prospective studies was more than 150 000. In the prospective studies, there were 64 severely thrombocytopenic newborns (platelet count < 50 × 109/L) of whom 3 had intracranial hemorrhage. The mothers of all 64 children were HLA-DRB3∗01:01+. The number of severely thrombocytopenic children born of HPA-1a-alloimmunized women in the retrospective studies was 214; 205 of whom were born of HLA-DRB3∗01:01+ women. For HLA-DRB3∗01:01- women, the OR (95% CI) for alloimmunization was 0.05 (0.00-0.60), and for severe neonatal thrombocytopenia 0.08 (0.02-0.37). This meta-analysis demonstrates that the risk of alloimmunization and of having a child with severe thrombocytopenia are both very low for HPA-1a- women who are HLA-DRB3∗01:01-.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
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Kjeldsen-Kragh, ...
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Fergusson, Dean ...
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Kjaer, Mette
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Lieberman, Lani
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Greinacher, Andr ...
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Murphy, Michael ...
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Bussel, James
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Bakchoul, Tamam
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Corke, Stacy
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Bertrand, Gérald
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Oepkes, Dick
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Baker, Jillian M ...
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Hume, Heather
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Massey, Edwin
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Kaplan, Cecile
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Arnold, Donald M ...
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Baidya, Shoma
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Ryan, Greg
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Savoia, Helen F.
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Landry, Denise
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Shehata, Nadine
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