Effects of B(1) inhomogeneity correction for three-dimensional variable flip angle T(1) measurements in hip dGEMRIC at 3 T and 1.5 T.

Siversson, CarlLund University,Lunds universitet,Enheten för led- och mjukvävnadsforskning,Forskargrupper vid Lunds universitet,Medicinsk strålningsfysik, Malmö,Joint and Soft Tissue Unit,Lund University Research Groups,Medical Radiation Physics, Malmö (author)

Delayed gadolinium-enhanced MRI of cartilage is a technique for studying the development of osteoarthritis using quantitative T(1) measurements. Three-dimensional variable flip angle is a promising method for performing such measurements rapidly, by using two successive spoiled gradient echo sequences with different excitation pulse flip angles. However, the three-dimensional variable flip angle method is very sensitive to inhomogeneities in the transmitted B(1) field in vivo. In this study, a method for correcting for such inhomogeneities, using an additional B(1) mapping spin-echo sequence, was evaluated. Phantom studies concluded that three-dimensional variable flip angle with B(1) correction calculates accurate T(1) values also in areas with high B(1) deviation. Retrospective analysis of in vivo hip delayed gadolinium-enhanced MRI of cartilage data from 40 subjects showed the difference between three-dimensional variable flip angle with and without B(1) correction to be generally two to three times higher at 3 T than at 1.5 T. In conclusion, the B(1) variations should always be taken into account, both at 1.5 T and at 3 T. Magn Reson Med, 2011. © 2011 Wiley-Liss, Inc.

Chan, Jenny (author)
Tiderius, Carl JohanLund University,Lunds universitet,Enheten för led- och mjukvävnadsforskning,Forskargrupper vid Lunds universitet,Joint and Soft Tissue Unit,Lund University Research Groups(Swepub:lu)orto-cti (author)
Mamisch, Tallal Charles (author)
Jellus, Vladimir (author)
Svensson, JonasLund University,Lunds universitet,Enheten för led- och mjukvävnadsforskning,Forskargrupper vid Lunds universitet,Medicinsk strålningsfysik, Malmö,Joint and Soft Tissue Unit,Lund University Research Groups,Medical Radiation Physics, Malmö(Swepub:lu)rfa-jsv (author)
Kim, Young-Jo (author)
Enheten för led- och mjukvävnadsforskningForskargrupper vid Lunds universitet (creator_code:org_t)

By the author/editor: Siversson, Carl; Chan, Jenny; Tiderius, Carl J ...; Mamisch, Tallal ...; Jellus, Vladimir; Svensson, Jonas; show more...; Kim, Young-Jo; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Radiology Nuclea ...

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