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Airway hyperrespons...
Airway hyperresponsiveness reflects corticosteroid-sensitive mast cell involvement across asthma phenotypes
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- Hvidtfeldt, Morten (author)
- Bispebjerg Hospital
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- Sverrild, Asger (author)
- Bispebjerg Hospital
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- Pulga, Alexis (author)
- Bispebjerg Hospital
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show more...
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- Frøssing, Laurits (author)
- Bispebjerg Hospital
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- Silberbrandt, Alexander (author)
- Bispebjerg Hospital
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- Hostrup, Morten (author)
- University of Copenhagen
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- Thomassen, Martin (author)
- University of Copenhagen
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- Sanden, Caroline (author)
- Medetect AB
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- Clausson, Carl Magnus (author)
- Lund University,Lunds universitet,Luftvägsinflammation,Forskargrupper vid Lunds universitet,Airway Inflammation and Immunology,Lund University Research Groups
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- Siddhuraj, Premkumar (author)
- Lund University,Lunds universitet,Luftvägsinflammation,Forskargrupper vid Lunds universitet,Airway Inflammation and Immunology,Lund University Research Groups
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- Bornesund, Daisy (author)
- Lund University,Lunds universitet,Luftvägsinflammation,Forskargrupper vid Lunds universitet,Airway Inflammation and Immunology,Lund University Research Groups
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- Nieto-Fontarigo, Juan Jose (author)
- Lund University,Lunds universitet,Respiratorisk immunofarmakologi,Forskargrupper vid Lunds universitet,Respiratory Immunopharmacology,Lund University Research Groups
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- Uller, Lena (author)
- Lund University,Lunds universitet,Respiratorisk immunofarmakologi,Forskargrupper vid Lunds universitet,Respiratory Immunopharmacology,Lund University Research Groups
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- Erjefält, Jonas (author)
- Lund University,Lunds universitet,Luftvägsinflammation,Forskargrupper vid Lunds universitet,DCD transplantation av lungor,Airway Inflammation and Immunology,Lund University Research Groups,DCD transplantation of lungs
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- Porsbjerg, Celeste (author)
- Bispebjerg Hospital
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(creator_code:org_t)
- Elsevier BV, 2023
- 2023
- English.
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In: Journal of Allergy and Clinical Immunology. - : Elsevier BV. - 0091-6749. ; 152:1, s. 4-116
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Abstract
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- Background: Airway hyperresponsiveness is a hallmark of asthma across asthma phenotypes. Airway hyperresponsiveness to mannitol specifically relates to mast cell infiltration of the airways, suggesting inhaled corticosteroids to be effective in reducing the response to mannitol, despite low levels of type 2 inflammation. Objective: We sought to investigate the relationship between airway hyperresponsiveness and infiltrating mast cells, and the response to inhaled corticosteroid treatment. Methods: In 50 corticosteroid-free patients with airway hyperresponsiveness to mannitol, mucosal cryobiopsies were obtained before and after 6 weeks of daily treatment with 1600 μg of budesonide. Patients were stratified according to baseline fractional exhaled nitric oxide (FENO) with a cutoff of 25 parts per billion. Results: Airway hyperresponsiveness was comparable at baseline and improved equally with treatment in both patients with FENO-high and FENO-low asthma: doubling dose, 3.98 (95% CI, 2.49-6.38; P < .001) and 3.85 (95% CI, 2.51-5.91; P < .001), respectively. However, phenotypes and distribution of mast cells differed between the 2 groups. In patients with FENO-high asthma, airway hyperresponsiveness correlated with the density of chymase-high mast cells infiltrating the epithelial layer (ρ, −0.42; P = .04), and in those with FENO-low asthma, it correlated with the density in the airway smooth muscle (ρ, −0.51; P = .02). The improvement in airway hyperresponsiveness after inhaled corticosteroid treatment correlated with a reduction in mast cells, as well as in airway thymic stromal lymphopoietin and IL-33. Conclusions: Airway hyperresponsiveness to mannitol is related to mast cell infiltration across asthma phenotypes, correlating with epithelial mast cells in patients with FENO-high asthma and with airway smooth muscle mast cells in patients with FENO-low asthma. Treatment with inhaled corticosteroids was effective in reducing airway hyperresponsiveness in both groups.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Keyword
- airway hyperresponsiveness
- Asthma
- inhaled corticosteroids
- mast cell
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Hvidtfeldt, Mort ...
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Sverrild, Asger
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Pulga, Alexis
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Frøssing, Laurit ...
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Silberbrandt, Al ...
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Hostrup, Morten
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show more...
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Thomassen, Marti ...
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Sanden, Caroline
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Clausson, Carl M ...
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Siddhuraj, Premk ...
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Bornesund, Daisy
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Nieto-Fontarigo, ...
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Uller, Lena
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Erjefält, Jonas
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Porsbjerg, Celes ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Respiratory Medi ...
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Journal of Aller ...
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Lund University