Search: WFRF:(Askmalm Stenmark Marie)
> (2020-2023) >
Whole-body MRI surv...
Whole-body MRI surveillance in TP53 carriers is perceived as beneficial with no increase in cancer worry regardless of previous cancer : Data from the Swedish TP53 Study
-
- Omran, Meis (author)
- Karolinska Institutet,Karolinska Institute,Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden; Cancer Theme, Karolinska University Hospital Solna, Stockholm, Sweden,Karolinska Inst, Dept Oncol Pathol, Anna Stecksens Gata 30A,D2 04, SE-17164 Stockholm, Sweden.;Karolinska Univ Hosp Solna, Canc Theme, Stockholm, Sweden.
-
- Johansson, Hemming (author)
- Karolinska Institutet,Karolinska Institute,Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Dept Oncol Pathol, Anna Stecksens Gata 30A,D2 04, SE-17164 Stockholm, Sweden.
-
- Lundgren, Claudia, 1966- (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi,Klinisk onkologi,Uppsala Univ Hosp, Sweden,Uppsala University Hospital
-
show more...
-
- Silander, Gustav (author)
- Umeå universitet,Umeå University,Institutionen för strålningsvetenskaper,Umeå Univ, Dept Radiat Sci, Umeå, Sweden.
-
- Stenmark-Askmalm, Marie (author)
- Division of Clinical Genetics, Department of Laboratory Medicine, Office for Medical Services, Skåne University Hospital, Lund, Sweden,Skane Univ Hosp, Dept Lab Med, Off Med Serv, Div Clin Genet, Lund, Sweden.
-
- Loman, Niklas (author)
- Lund University,Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Bröst/ovarialcancer,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Breast/ovarian cancer,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Division of Oncology and Pathology, Department of Clinical Sciences, Lund University, Lund, Sweden; Department of Hematology, Oncology and Radiation Physics, Skåne University Hospital, Malmö, Sweden,Lund Univ, Dept Clin Sci, Div Oncol & Pathol, Lund, Sweden.;Skane Univ Hosp, Dept Hematol Oncol & Radiat Phys, Malmö, Sweden.
-
- Baan, Annika (author)
- Department of Oncology, Sahlgrenska University Hospital, Gothenburg, Sweden,Sahlgrens Univ Hosp, Dept Oncol, Gothenburg, Sweden.
-
- Adra, Jamila (author)
- Department of Oncology, Sahlgrenska University Hospital, Gothenburg, Sweden,Sahlgrens Univ Hosp, Dept Oncol, Gothenburg, Sweden.
-
- Kuchinskaya, Ekaterina, 1973- (author)
- Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten,Region Östergötland, Klinisk genetik,Linköping University Hospital
-
- Blomqvist, Lennart (author)
- Karolinska Institutet,Karolinska Institute,Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden; Department of Imaging and Physiology, Karolinska University Hospital Solna, Stockholm, Sweden,Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden.;Karolinska Univ Hosp Solna, Dept Imaging & Physiol, Stockholm, Sweden.
-
- Tham, Emma (author)
- Karolinska Institutet,Karolinska Institute,Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden; Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden,Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden.;Karolinska Univ Hosp, Clin Genet, Stockholm, Sweden.
-
- Bajalica-Lagercrantz, Svetlana (author)
- Karolinska Institute,Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden; Cancer Theme, Karolinska University Hospital Solna, Stockholm, Sweden; Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden,Karolinska Inst, Dept Oncol Pathol, Anna Stecksens Gata 30A,D2 04, SE-17164 Stockholm, Sweden.;Karolinska Univ Hosp Solna, Canc Theme, Stockholm, Sweden.;Karolinska Univ Hosp, Clin Genet, Stockholm, Sweden.
-
- Brandberg, Yvonne (author)
- Karolinska Institutet,Karolinska Institute,Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Dept Oncol Pathol, Anna Stecksens Gata 30A,D2 04, SE-17164 Stockholm, Sweden.
-
show less...
-
(creator_code:org_t)
-
- 2023-01-05
- 2023
- English.
-
In: Cancer. - : Wiley. - 0008-543X .- 1097-0142. ; 129:6, s. 946-955
- Related links:
-
http://dx.doi.org/10... (free)
-
show more...
-
https://doi.org/10.1...
-
https://umu.diva-por... (primary) (Raw object)
-
https://uu.diva-port... (primary) (Raw object)
-
https://liu.diva-por... (primary) (Raw object)
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
https://urn.kb.se/re...
-
http://kipublication...
-
https://urn.kb.se/re...
-
show less...
Abstract
Subject headings
Close
- Background: To evaluate the psychosocial consequences of surveillance with whole-body MRI (WB-MRI) in individuals with the heritable TP53-related cancer (hTP53rc) syndrome, also known as the Li-Fraumeni syndrome, with regard to cancer worry, perceived benefits and risks to surveillance and overall health. Patients and methods: Since 2016, the national Swedish TP53 Study (SWEP53) has offered surveillance with WB-MRI to all individuals with hTP53rc syndrome. Seventy-five individuals have been included in the study. Sixty consecutive participants fulfilled a base-line evaluation as well as an evaluation after 1 year with structured questionnaires including the Cancer Worry Scale (CWS), perceived benefits and risks of surveillance, and the 36-item Short Form Survey (SF-36). Individuals with or without previous personal cancer diagnosis were enrolled and results at baseline and after 1 year of surveillance were compared. For SF-36, a comparison with the normal population was also made. Results: Participants with previous cancer tend to worry more about cancer, but both individuals with and without cancer had a positive attitude toward surveillance with no differences regarding perceived benefits and barriers to surveillance. Participants with a previous cancer scored significantly lower on some of the SF-36 subscales, but between-group differences were found only for social functioning after 1 year. Conclusions: Surveillance with WB-MRI is feasible from a psychosocial point of view both among TP53 carriers with as well as without a previous history of cancer and does not increase cancer worry in any of the groups. Plain language summary: Individuals with heritable TP53-related cancer syndrome (also known as the Li-Fraumeni syndrome) have a high lifetime risk of developing cancer. These TP53 carriers are offered surveillance with whole-body MRI to detect cancer early. There are few reports of the psychosocial impact of surveillance. In this study, we wanted to evaluate cancer worry, benefits and barriers to participation, and perceived overall health. Our study shows no increase in cancer worry after 1 year of surveillance, regardless of previous cancer.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- cancer worry scale
- health-related quality-of-life
- hereditary cancer
- heritable TP53-related cancer syndromes
- Li-Fraumeni syndrome
- surveillance
- cancer worry scale
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
-
Cancer
(Search for host publication in LIBRIS)
To the university's database
- By the author/editor
-
Omran, Meis
-
Johansson, Hemmi ...
-
Lundgren, Claudi ...
-
Silander, Gustav
-
Stenmark-Askmalm ...
-
Loman, Niklas
-
show more...
-
Baan, Annika
-
Adra, Jamila
-
Kuchinskaya, Eka ...
-
Blomqvist, Lenna ...
-
Tham, Emma
-
Bajalica-Lagercr ...
-
Brandberg, Yvonn ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cancer and Oncol ...
- Articles in the publication
-
Cancer
- By the university
-
Lund University
-
Umeå University
-
Uppsala University
-
Karolinska Institutet
-
Linköping University