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Blood-based omic pr...
Blood-based omic profiling supports female susceptibility to tobacco smoke-induced cardiovascular diseases
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- Chatziioannou, Aristotelis (author)
- National Hellenic Research Foundation
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- Georgiadis, Panagiotis (author)
- National Hellenic Research Foundation
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- Hebels, Dennie G. (author)
- Maastricht University
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- Liampa, Irene (author)
- National Hellenic Research Foundation
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- Valavanis, Ioannis (author)
- National Hellenic Research Foundation
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- Bergdahl, Ingvar A. (author)
- Umeå universitet,Umeå University,Yrkes- och miljömedicin,Enheten för biobanksforskning
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- Johansson, Anders (author)
- Lund University,Lunds universitet,Umeå universitet,Umeå University,Näringsforskning,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine
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- Palli, Domenico (author)
- Cancer Research and Prevention Institute (ISPO)
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- Chadeau-Hyam, Marc (author)
- Imperial College London
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- Siskos, Alexandros P. (author)
- Imperial College London
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- Keun, Hector (author)
- Imperial College London
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- Botsivali, Maria (author)
- National Hellenic Research Foundation
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- De Kok, Theo M C M (author)
- Maastricht University
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- Pérez, Almudena Espín (author)
- Maastricht University
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- Kleinjans, Jos C S (author)
- Maastricht University
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- Vineis, Paolo (author)
- Imperial College London
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- Kyrtopoulos, Soterios A. (author)
- National Hellenic Research Foundation
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- Gottschalk, Ralph (author)
- Maastricht University
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- Van Leeuwen, Danitsja (author)
- Maastricht University
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- Timmermans, Leen (author)
- Maastricht University
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- Bendinelli, Benedetta (author)
- Cancer Research and Prevention Institute (ISPO)
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- Kelly, Rachel (author)
- Imperial College London
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- Vermeulen, Roel (author)
- Utrecht University
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- Portengen, Lutzen (author)
- Utrecht University
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- Saberi Hosnijeh, Fatemeh (author)
- Utrecht University
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- Melin, Beatrice (author)
- Umeå University
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- Hallmans, Goran (author)
- Umeå University
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- Lenner, Per (author)
- Umeå University
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- Athersuch, Toby J. (author)
- Imperial College London
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- Kogevinas, Manolis (author)
- Centre for Research in Environmental Epidemiology
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- Stephanou, Euripides G. (author)
- University of Crete
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- Myridakis, Antonis (author)
- University of Crete
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- Fazzo, Lucia (author)
- Italian National Institute of Health (ISS)
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- De Santis, Marco (author)
- Italian National Institute of Health (ISS)
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- Comba, Pietro (author)
- Italian National Institute of Health (ISS)
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- Kiviranta, Hannu (author)
- Finnish National Institute for Health and Welfare
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- Rantakokko, Panu (author)
- Finnish National Institute for Health and Welfare
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- Airaksinen, Riikka (author)
- Finnish National Institute for Health and Welfare
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- Ruokojarvi, Paivi (author)
- Finnish National Institute for Health and Welfare
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- Gilthorpe, Mark (author)
- University of Leeds
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- Fleming, Sarah (author)
- University of Leeds
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- Fleming, Thomas (author)
- University of Leeds
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- Tu, Yu Kang (author)
- University of Leeds
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- Jönsson, Bo A (author)
- Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine
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- Lundh, Thomas (author)
- Lund University,Lunds universitet,Genetisk arbets- och miljömedicin,Forskargrupper vid Lunds universitet,Genetic Occupational and Environmental Medicine,Lund University Research Groups
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- Chen, Wei-Jung (author)
- National Taiwan University
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- Lee, Wen Chung (author)
- National Taiwan University
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- Hsiao, Chuhsing Kate (author)
- National Taiwan University
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- Chien, Kuo Liong (author)
- National Taiwan University
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- Kuo, Po Hsiu (author)
- National Taiwan University
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- Hung, Hung (author)
- National Taiwan University
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- Liao, Shu Fen (author)
- National Taiwan University
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(creator_code:org_t)
- 2017-02-22
- 2017
- English.
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In: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 7
- Related links:
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http://dx.doi.org/10... (free)
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https://www.nature.c...
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- We recently reported that differential gene expression and DNA methylation profiles in blood leukocytes of apparently healthy smokers predicts with remarkable efficiency diseases and conditions known to be causally associated with smoking, suggesting that blood-based omic profiling of human populations may be useful for linking environmental exposures to potential health effects. Here we report on the sex-specific effects of tobacco smoking on transcriptomic and epigenetic features derived from genome-wide profiling in white blood cells, identifying 26 expression probes and 92 CpG sites, almost all of which are affected only in female smokers. Strikingly, these features relate to numerous genes with a key role in the pathogenesis of cardiovascular disease, especially thrombin signaling, including the thrombin receptors on platelets F2R (coagulation factor II (thrombin) receptor; PAR1) and GP5 (glycoprotein 5), as well as HMOX1 (haem oxygenase 1) and BCL2L1 (BCL2-like 1) which are involved in protection against oxidative stress and apoptosis, respectively. These results are in concordance with epidemiological evidence of higher female susceptibility to tobacco-induced cardiovascular disease and underline the potential of blood-based omic profiling in hazard and risk assessment.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Beroendelära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Substance Abuse (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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Chatziioannou, A ...
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Georgiadis, Pana ...
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Hebels, Dennie G ...
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Liampa, Irene
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Valavanis, Ioann ...
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Bergdahl, Ingvar ...
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show more...
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Johansson, Ander ...
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Palli, Domenico
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Chadeau-Hyam, Ma ...
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Siskos, Alexandr ...
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Keun, Hector
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Botsivali, Maria
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De Kok, Theo M C ...
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Pérez, Almudena ...
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Kleinjans, Jos C ...
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Vineis, Paolo
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Kyrtopoulos, Sot ...
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Gottschalk, Ralp ...
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Van Leeuwen, Dan ...
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Timmermans, Leen
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Bendinelli, Bene ...
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Kelly, Rachel
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Vermeulen, Roel
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Portengen, Lutze ...
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Saberi Hosnijeh, ...
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Melin, Beatrice
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Hallmans, Goran
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Lenner, Per
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Athersuch, Toby ...
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Kogevinas, Manol ...
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Stephanou, Eurip ...
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Myridakis, Anton ...
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Fazzo, Lucia
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De Santis, Marco
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Comba, Pietro
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Kiviranta, Hannu
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Rantakokko, Panu
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Airaksinen, Riik ...
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Ruokojarvi, Paiv ...
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Gilthorpe, Mark
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Fleming, Sarah
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Fleming, Thomas
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Tu, Yu Kang
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Jönsson, Bo A
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Lundh, Thomas
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Chen, Wei-Jung
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Lee, Wen Chung
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Hsiao, Chuhsing ...
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Chien, Kuo Liong
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Kuo, Po Hsiu
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Hung, Hung
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Liao, Shu Fen
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Substance Abuse
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Public Health Gl ...
- Articles in the publication
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Scientific Repor ...
- By the university
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Lund University
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Umeå University