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  • Barrdahl, MyrtoGerman Cancer Research Centre (author)

A comprehensive analysis of polymorphic variants in steroid hormone and insulin-like growth factor-1 metabolism and risk of in situ breast cancer : Results from the Breast and Prostate Cancer Cohort Consortium

  • Article/chapterEnglish2018

Publisher, publication year, extent ...

  • 2017-11-17
  • Wiley,2018

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:91a327f2-0f1e-4f4a-bc2e-b75ed6316b51
  • https://lup.lub.lu.se/record/91a327f2-0f1e-4f4a-bc2e-b75ed6316b51URI
  • https://doi.org/10.1002/ijc.31145DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:137431929URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • We assessed the association between 1,414 single nucleotide polymorphisms (SNPs) in genes involved in synthesis and metabolism of steroid hormones and insulin-like growth factor 1, and risk of breast cancer in situ (BCIS), with the aim of determining whether any of these were disease specific. This was carried out using 1,062 BCIS cases and 10,126 controls as well as 6,113 invasive breast cancer cases from the Breast and Prostate Cancer Cohort Consortium (BPC3). Three SNPs showed at least one nominally significant association in homozygous minor versus homozygous major models. ACVR2A-rs2382112 (ORhom=3.05, 95%CI=1.72-5.44, Phom=1.47 × 10-4), MAST2-rs12124649 (ORhom=1.73, 95% CI =1.18-2.54, Phom=5.24 × 10-3), and INSR-rs10500204 (ORhom=1.96, 95% CI=1.44-2.67, Phom=1.68 × 10-5) were associated with increased risk of BCIS; however, only the latter association was significant after correcting for multiple testing. Furthermore, INSR-rs10500204 was more strongly associated with the risk of BCIS than invasive disease in case-only analyses using the homozygous minor versus homozygous major model (ORhom=1.78, 95% CI=1.30-2.44, Phom=3.23 × 10-4). The SNP INSR-rs10500204 is located in an intron of the INSR gene and is likely to affect binding of the promyelocytic leukemia (PML) protein. The PML gene is known as a tumor suppressor and growth regulator in cancer. However, it is not clear on what pathway the A-allele of rs10500204 could operate to influence the binding of the protein. Hence, functional studies are warranted to investigate this further.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Canzian, FedericoGerman Cancer Research Centre (author)
  • Gaudet, Mia M. (author)
  • Gapstur, Susan M. (author)
  • Trichopoulou, AntoniaHellenic Health Foundation, Athens (author)
  • Tsilidis, KostasImperial College London (author)
  • van Gils, Carla H.University Medical Center Utrecht (author)
  • Borgquist, SigneLund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Bröstcancer - prevention & intervention,Forskargrupper vid Lunds universitet,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Breast cancer prevention & intervention,Lund University Research Groups,Skåne University Hospital(Swepub:lu)ront-sbo (author)
  • Weiderpass, ElisabeteKarolinska Institutet,Karolinska Institute (author)
  • Khaw, Kay TeeUniversity of Cambridge (author)
  • Giles, Graham G.University of Melbourne (author)
  • Milne, Roger L.University of Melbourne (author)
  • Le Marchand, LoicUniversity of Hawai'i at Hilo (author)
  • Haiman, ChristopherUniversity of Southern California (author)
  • Lindström, SaraFred Hutchinson Cancer Research Center (author)
  • Kraft, PeterHarvard University (author)
  • Hunter, David J.Harvard University (author)
  • Ziegler, ReginaNational Cancer Institute, NCI (author)
  • Chanock, Stephen J. (author)
  • Yang, Xiaohong R. (author)
  • Buring, Julie E.Brigham and Women's Hospital / Harvard Medical School (author)
  • Lee, I. MinBrigham and Women's Hospital / Harvard Medical School (author)
  • Kaaks, RudolfGerman Cancer Research Centre (author)
  • Campa, DanieleUniversity of Pisa (author)
  • German Cancer Research CentreHellenic Health Foundation, Athens (creator_code:org_t)

Related titles

  • In:International Journal of Cancer: Wiley142:6, s. 1182-11880020-71361097-0215

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