Search: id:"swepub:oai:lup.lub.lu.se:924b8cf1-62bf-4e5a-8cc8-c97dd73f0032" >
Repairing the brain...
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Henchcliffe, ClaireMemorial Sloan-Kettering Cancer Center,Cornell University
(author)
Repairing the brain : Cell replacement using stem cell-based technologies
- Article/chapterEnglish2018
Publisher, publication year, extent ...
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2018
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electronicrdacarrier
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LIBRIS-ID:oai:lup.lub.lu.se:924b8cf1-62bf-4e5a-8cc8-c97dd73f0032
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https://lup.lub.lu.se/record/924b8cf1-62bf-4e5a-8cc8-c97dd73f0032URI
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https://doi.org/10.3233/JPD-181488DOI
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Language:English
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Summary in:English
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Subject category:for swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Current approaches to cell replacement therapy in Parkinson's disease are strongly focused on the dopamine system, with the view that restoring dopaminergic inputs in a localized and physiologic manner will provide superior benefits in terms of effect and longevity compared with oral medication. Experience using transplants of fetal tissue containing dopaminergic cell precursors has provided valuable proof that the approach is feasible, and that engrafted cells can survive and function over many years. However, multiple drawbacks and procedural complications are recognized in using fetal cells. Recent strides in stem cell technology now make it possible to overcome some of the barriers associated with fetal tissue. In particular the generation of high numbers of specific cell types, such as dopaminergic neurons, from stem cells means that quality, consistency, activity, and safety can be more thoroughly determined prior to transplantation, thus providing hope for more robust outcomes. These cells are also predicted to provide benefit without leading to the graft-induced dyskinesia that led to morbidity in a subset of individuals who underwent fetal mesencephalic cell and tissue grafting in the 1990s. In thinking about developing such novel therapeutics, the choice of starting material has also expanded, with the availability of multiple human embryonic stem cell lines, as well as the possibilities for producing induced pluripotent cells, or neuronal cells from a patient's own tissue. In this article, we speculate on how rapidly expanding knowledge and technical possibilities may impact on stem cell-based therapies for cell replacement in Parkinson's disease over the next two decades.
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Added entries (persons, corporate bodies, meetings, titles ...)
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Parmar, MalinLund University,Lunds universitet,Utvecklings- och regenerativ neurobiologi,Forskargrupper vid Lunds universitet,Developmental and Regenerative Neurobiology,Lund University Research Groups(Swepub:lu)mphy-mpa
(author)
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Memorial Sloan-Kettering Cancer CenterCornell University
(creator_code:org_t)
Related titles
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In:Journal of Parkinson's Disease8:s1, s. 131-1371877-7171
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