SwePub
Sök i LIBRIS databas

  Utökad sökning

L773:2312 0541
 

Sökning: L773:2312 0541 > (2018) > Distal respiratory ...

  • Andersson, Cecilia KLund University,Lunds universitet,Luftvägsinflammation,Forskargrupper vid Lunds universitet,Respiratorisk immunofarmakologi,Respiratorisk cellbiologi,Airway Inflammation and Immunology,Lund University Research Groups,Respiratory Immunopharmacology,Respiratory Cell Biology (författare)

Distal respiratory tract viral infections in young children trigger a marked increase in alveolar mast cells

  • Artikel/kapitelEngelska2018

Förlag, utgivningsår, omfång ...

  • 2018-11-22
  • European Respiratory Society (ERS),2018

Nummerbeteckningar

  • LIBRIS-ID:oai:lup.lub.lu.se:9300ef3a-bce0-451c-97b9-448656f271e5
  • https://lup.lub.lu.se/record/9300ef3a-bce0-451c-97b9-448656f271e5URI
  • https://doi.org/10.1183/23120541.00038-2018DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype

Anmärkningar

  • Viral infections predispose to the development of childhood asthma, a disease associated with increased lung mast cells (MCs). This study investigated whether viral lower respiratory tract infections (LRTIs) can already evoke a MC response during childhood. Lung tissue from young children who died following LRTIs were processed for immunohistochemical identification of MCs. Children who died from nonrespiratory causes served as controls. MCs were examined in relation to sensitisation in infant mice exposed to allergen during influenza A infection. Increased numbers of MCs were observed in the alveolar parenchyma of children infected with LRTIs (median (range) 12.5 (0-78) MCs per mm2) compared to controls (0.63 (0-4) MCs per mm2, p=0.0005). The alveolar MC expansion was associated with a higher proportion of CD34+ tryptase+ progenitors (controls: 0% (0-1%); LRTIs: 0.9% (0-3%) CD34+ MCs (p=0.01)) and an increased expression of the vascular cell adhesion molecule (VCAM)-1 (controls: 0.2 (0.07-0.3); LRTIs: 0.3 (0.02-2) VCAM-1 per mm2 (p=0.04)). Similarly, infant mice infected with H1N1 alone or together with house dust mite (HDM) developed an increase in alveolar MCs (saline: 0.4 (0.3-0.5); HDM: 0.6 (0.4-0.9); H1N1: 1.4 (0.4-2.0); HDM+H1N1: 2.2 (1.2-4.4) MCs per mm2 (p<0.0001)). Alveolar MCs continued to increase and remained significantly higher into adulthood when exposed to H1N1+HDM (day 36: 2.2 (1.2-4.4); day 57: 4.6 (1.6-15) MCs per mm2 (p=0.01)) but not when infected with H1N1 alone. Our data demonstrate that distal viral infections in young children evoke a rapid accumulation of alveolar MCs. Apart from revealing a novel immune response to distal infections, our data may have important implications for the link between viral infections during early childhood and subsequent asthma development.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Shikhagaie, MedyaLund University,Lunds universitet,Luftvägsinflammation,Forskargrupper vid Lunds universitet,Airway Inflammation and Immunology,Lund University Research Groups(Swepub:lu)med-mys (författare)
  • Mori, MichikoLund University,Lunds universitet,Luftvägsinflammation,Forskargrupper vid Lunds universitet,Airway Inflammation and Immunology,Lund University Research Groups(Swepub:lu)med-mhm (författare)
  • Al-Garawi, AmalMcMaster University (författare)
  • Reed, Jennifer LUnited States Food and Drug Administration (författare)
  • Humbles, Alison AMedImmune, Inc. (författare)
  • Welliver, RobertUniversity of Oklahoma (författare)
  • Mauad, ThaisUniversity of São Paulo (författare)
  • Bjermer, LeifLund University,Lunds universitet,Lungmedicin, allergologi och palliativ medicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Respiratory Medicine, Allergology, and Palliative Medicine,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)lung-lbj (författare)
  • Jordana, ManelMcMaster University (författare)
  • Erjefält, Jonas SLund University,Lunds universitet,Luftvägsinflammation,Forskargrupper vid Lunds universitet,Airway Inflammation and Immunology,Lund University Research Groups(Swepub:lu)mphy-jer (författare)
  • LuftvägsinflammationForskargrupper vid Lunds universitet (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:ERJ Open Research: European Respiratory Society (ERS)4:42312-0541

Internetlänk

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy