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ETFAD/EADV Eczema t...
ETFAD/EADV Eczema task force 2020 position paper on diagnosis and treatment of atopic dermatitis in adults and children
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- Wollenberg, A. (författare)
- Ludwig-Maximilian University of Munich
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- Christen-Zäch, S. (författare)
- Lausanne University Hospital
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- Taieb, A. (författare)
- University of Bordeaux
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- Paul, C. (författare)
- University of Toulouse,Toulouse University Hospital
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- Thyssen, J. P. (författare)
- University of Copenhagen,Herlev Hospital
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- de Bruin-Weller, M. (författare)
- University Medical Center Utrecht
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- Vestergaard, C. (författare)
- Aarhus University Hospital
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- Seneschal, J. (författare)
- Centre Hospitalier Universitaire de Bordeaux
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- Werfel, T. (författare)
- Hannover Medical School
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- Cork, M. J. (författare)
- University of Sheffield
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- Kunz, B. (författare)
- Dermatologikum Hamburg
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- Fölster-Holst, R. (författare)
- University Medical Center Schleswig-Holstein
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- Trzeciak, M. (författare)
- Medical University of Gdansk
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- Darsow, U. (författare)
- Technical University of Munich,ZAUM - Center of Allergy and Environment
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- Szalai, Z. (författare)
- Heim Pal Children's Hospital
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- Deleuran, M. (författare)
- Aarhus University Hospital
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- von Kobyletzki, L. (författare)
- Örebro University,Lund University,Lunds universitet,Yrkes- och miljödermatologi,Forskargrupper vid Lunds universitet,Occupational and Environmental Dermatology,Lund University Research Groups
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- Barbarot, S. (författare)
- University of Nantes,Nantes University Hospital
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- Heratizadeh, A. (författare)
- Hannover Medical School
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- Gieler, U. (författare)
- Justus Liebig University Giessen
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- Hijnen, D. J. (författare)
- Erasmus University Medical Center
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- Weidinger, S. (författare)
- University Medical Center Schleswig-Holstein
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- De Raeve, L. (författare)
- Vrije Universiteit Brussel (VUB),Universitair Ziekenhuis Brussel
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- Simon, D. (författare)
- University of Bern,Bern University Hospital
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- Stalder, J. F. (författare)
- Nantes University Hospital,University of Nantes
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- Ring, J. (författare)
- Technical University of Munich,Christine Kühne Center for Allergy Research and Education (CK-CARE)
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(creator_code:org_t)
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- 2020-11-17
- 2020
- Engelska 28 s.
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Ingår i: Journal of the European Academy of Dermatology and Venereology. - : Wiley. - 0926-9959 .- 1468-3083. ; 34:12, s. 2717-2744
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http://dx.doi.org/10... (free)
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https://repub.eur.nl...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Atopic dermatitis (AD) is a highly pruritic, chronic inflammatory skin disease. The diagnosis is made using evaluated clinical criteria. Disease activity and burden are best measured with a composite score, assessing both objective and subjective symptoms, such as SCORing Atopic Dermatitis (SCORAD). AD management must take into account clinical and pathogenic variabilities, the patient’s age and also target flare prevention. Basic therapy includes hydrating and barrier-stabilizing topical treatment universally applied, as well as avoiding specific and unspecific provocation factors. Visible skin lesions are treated with anti-inflammatory topical agents such as corticosteroids and calcineurin inhibitors (tacrolimus and pimecrolimus), which are preferred in sensitive locations. Topical tacrolimus and some mid-potency corticosteroids are proven agents for proactive therapy, which is defined as the long-term intermittent anti-inflammatory therapy of frequently relapsing skin areas. Systemic anti-inflammatory or immunosuppressive treatment is a rapidly changing field requiring monitoring. Oral corticosteroids have a largely unfavourable benefit–risk ratio. The IL-4R-blocker dupilumab is a safe, effective and licensed, but expensive, treatment option with potential ocular side-effects. Other biologicals targeting key pathways in the atopic immune response, as well as different Janus kinase inhibitors, are among emerging treatment options. Dysbalanced microbial colonization and infection may induce disease exacerbation and can justify additional antimicrobial treatment. Systemic antihistamines (H1R-blockers) only have limited effects on AD-related itch and eczema lesions. Adjuvant therapy includes UV irradiation, preferably narrowband UVB or UVA1. Coal tar may be useful for atopic hand and foot eczema. Dietary recommendations should be patient-specific, and elimination diets should only be advised in case of proven food allergy. Allergen-specific immunotherapy to aeroallergens may be useful in selected cases. Psychosomatic counselling is recommended to address stress-induced exacerbations. Efficacy-proven 'Eczema school' educational programmes and therapeutic patient education are recommended for both children and adults.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Dermatologi och venereologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dermatology and Venereal Diseases (hsv//eng)
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- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Wollenberg, A.
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Christen-Zäch, S ...
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Taieb, A.
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Paul, C.
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Thyssen, J. P.
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de Bruin-Weller, ...
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visa fler...
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Vestergaard, C.
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Seneschal, J.
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Werfel, T.
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Cork, M. J.
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Kunz, B.
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Fölster-Holst, R ...
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Trzeciak, M.
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Darsow, U.
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Szalai, Z.
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Deleuran, M.
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von Kobyletzki, ...
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Barbarot, S.
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Heratizadeh, A.
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Gieler, U.
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Hijnen, D. J.
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Weidinger, S.
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De Raeve, L.
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Simon, D.
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Stalder, J. F.
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Ring, J.
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