Sökning: WFRF:(Gouignard Nadège)
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Gene expression of ...
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Gouignard, NadègeLund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine
(författare)
Gene expression of the two developmentally regulated dermatan sulfate epimerases in the Xenopus embryo
- Artikel/kapitelEngelska2018
Förlag, utgivningsår, omfång ...
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2018-01-25
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Public Library of Science (PLoS),2018
Nummerbeteckningar
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LIBRIS-ID:oai:lup.lub.lu.se:9335b4ca-7b1d-4fb6-9b4d-af7e9f367504
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https://lup.lub.lu.se/record/9335b4ca-7b1d-4fb6-9b4d-af7e9f367504URI
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https://doi.org/10.1371/journal.pone.0191751DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
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Chondroitin sulfate (CS)/dermatan sulfate (DS) proteoglycans are abundant on the cell surface and in the extracellular matrix and have important functions in matrix structure, cell-matrix interaction and signaling. The DS epimerases 1 and 2, encoded by Dse and Dsel, respectively, convert CS to a CS/DS hybrid chain, which is structurally and conformationally richer than CS, favouring interaction with matrix proteins and growth factors. We recently showed that Xenopus Dse is essential for the migration of neural crest cells by allowing cell surface CS/DS proteoglycans to adhere to fibronectin. Here we investigate the expression of Dse and Dsel in Xenopus embryos. We show that both genes are maternally expressed and exhibit partially overlapping activity in the eyes, brain, trigeminal ganglia, neural crest, adenohypophysis, sclerotome, and dorsal endoderm. Dse is specifically expressed in the epidermis, anterior surface ectoderm, spinal nerves, notochord and dermatome, whereas Dsel mRNA alone is transcribed in the spinal cord, epibranchial ganglia, prechordal mesendoderm and myotome. The expression of the two genes coincides with sites of cell differentiation in the epidermis and neural tissue. Several expression domains can be linked to previously reported phenotypes of knockout mice and clinical manifestations, such as the Musculocontractural Ehlers-Danlos syndrome and psychiatric disorders.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Schön, TanjaLund University
(författare)
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Holmgren, ChristianLund University,Lunds universitet,Tumörcellsbiologi,Forskargrupper vid Lunds universitet,Tumor Cell Biology,Lund University Research Groups(Swepub:lu)med-chg
(författare)
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Strate, InaLund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)med-ias
(författare)
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Taşöz, EmirhanLund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)em8775ta
(författare)
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Wetzel, FranziskaLund University
(författare)
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Maccarana, MarcoLund University,Lunds universitet,Matrixbiologi,Forskargrupper vid Lunds universitet,Matrix Biology,Lund University Research Groups(Swepub:lu)medk-mm0
(författare)
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Pera, Edgar M.Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)med-eap
(författare)
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Stamcellscentrum (SCC)Avdelningen för stamcellsforskning
(creator_code:org_t)
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Ingår i:PLoS ONE: Public Library of Science (PLoS)13:11932-6203
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