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Infarct quantificat...
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Heiberg, EinarLund University,Lunds universitet,Hjärt-MR-gruppen i Lund,Forskargrupper vid Lunds universitet,WCMM- Wallenberg center för molekylär medicinsk forskning,Medicinska fakulteten,LTH profilområde: Teknik för hälsa,LTH profilområden,Lunds Tekniska Högskola,Lund Cardiac MR Group,Lund University Research Groups,WCMM-Wallenberg Centre for Molecular Medicine,Faculty of Medicine,LTH Profile Area: Engineering Health,LTH Profile areas,Faculty of Engineering, LTH,Skåne University Hospital
(författare)
Infarct quantification with cardiovascular magnetic resonance using "standard deviation from remote" is unreliable : validation in multi-centre multi-vendor data
- Artikel/kapitelEngelska2022
Förlag, utgivningsår, omfång ...
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2022-11-07
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Springer Science and Business Media LLC,2022
Nummerbeteckningar
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LIBRIS-ID:oai:lup.lub.lu.se:933d908c-28a4-4631-8ce1-85c4e2fc7c10
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https://lup.lub.lu.se/record/933d908c-28a4-4631-8ce1-85c4e2fc7c10URI
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https://doi.org/10.1186/s12968-022-00888-8DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Background: The objective of the study was to investigate variability and agreement of the commonly used image processing method “n-SD from remote” and in particular for quantifying myocardial infarction by late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR). LGE-CMR in tandem with the analysis method “n-SD from remote” represents the current reference standard for infarct quantification. This analytic method utilizes regions of interest (ROIs) and defines infarct as the tissue with a set number of standard deviations (SD) above the signal intensity of remote nulled myocardium. There is no consensus on what the set number of SD is supposed to be. Little is known about how size and location of ROIs and underlying signal properties in the LGE images affect results. Furthermore, the method is frequently used elsewhere in medical imaging often without careful validation. Therefore, the usage of the “n-SD” method warrants a thorough validation. Methods: Data from 214 patients from two multi-center cardioprotection trials were included. Infarct size from different remote ROI positions, ROI size, and number of standard deviations (“n-SD”) were compared with reference core lab delineations. Results: Variability in infarct size caused by varying ROI position, ROI size, and “n-SD” was 47%, 48%, and 40%, respectively. The agreement between the “n-SD from remote” method and the reference infarct size by core lab delineations was low. Optimal “n-SD” threshold computed on a slice-by-slice basis showed high variability, n = 5.3 ± 2.2. Conclusion: The “n-SD from remote” method is unreliable for infarct quantification due to high variability which depends on different placement and size of remote ROI, number “n-SD”, and image signal properties related to the CMR-scanner and sequence used. Therefore, the “n-SD from remote” method should not be used, instead methods validated against an independent standard are recommended.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Engblom, HenrikLund University,Lunds universitet,Hjärt-MR-gruppen i Lund,Forskargrupper vid Lunds universitet,Lund Cardiac MR Group,Lund University Research Groups,Skåne University Hospital(Swepub:lu)klin-hen
(författare)
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Carlsson, MarcusLund University,Lunds universitet,Hjärt-MR-gruppen i Lund,Forskargrupper vid Lunds universitet,Lund Cardiac MR Group,Lund University Research Groups,National Heart Lung and Blood Institute,Skåne University Hospital(Swepub:lu)klin-mca
(författare)
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Erlinge, DavidLund University,Lunds universitet,Molekylär kardiologi,Forskargrupper vid Lunds universitet,Molecular Cardiology,Lund University Research Groups,Skåne University Hospital(Swepub:lu)kard-der
(författare)
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Atar, DanOslo university hospital,University of Oslo
(författare)
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Aletras, Anthony H.Lund University,Lunds universitet,Hjärt-MR-gruppen i Lund,Forskargrupper vid Lunds universitet,Lund Cardiac MR Group,Lund University Research Groups,Aristotle University of Thessaloniki,Skåne University Hospital(Swepub:lu)med-aya
(författare)
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Arheden, HåkanLund University,Lunds universitet,Hjärt-MR-gruppen i Lund,Forskargrupper vid Lunds universitet,Lund Cardiac MR Group,Lund University Research Groups,Skåne University Hospital(Swepub:lu)klfy-har
(författare)
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Hjärt-MR-gruppen i LundForskargrupper vid Lunds universitet
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of Cardiovascular Magnetic Resonance: Springer Science and Business Media LLC24:11097-66471532-429X
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