WFRF:(Rao N.)
Sökning: WFRF:(Rao N.) > (2005-2009) > Wnt-5a has tumor su...
- Kremenevskaja, N (författare)
Wnt-5a has tumor suppressor activity in thyroid carcinoma
- Artikel/kapitelEngelska2005
Förlag, utgivningsår, omfång ...
- 2005-02-14
- Springer Science and Business Media LLC,2005
Nummerbeteckningar
- LIBRIS-ID:oai:lup.lub.lu.se:93573fd9-1693-4c91-be5a-fd307f6e202b
- https://lup.lub.lu.se/record/896996URI
- https://doi.org/10.1038/sj.onc.1208370DOI
Kompletterande språkuppgifter
- Språk:engelska
- Sammanfattning på:engelska
Ingår i deldatabas
- SwePubSwePub
Klassifikation
Anmärkningar
- Stabilization of beta-catenin by inhibition of its phosphorylation is characteristic of an activation of the canonical Wnt/beta-catenin signaling pathway and is associated with various human carcinomas. It contrasts to an as yet incompletely characterized action of an alternative noncanonical Wnt signaling pathway on neoplastic transformation. The aim of the present study was to test the effects of a member of the noncanonical Wnt signaling pathway, Wnt-5a, in primary thyroid carcinomas and in thyroid carcinoma cell lines. Compared to normal tissue Wnt-5a mRNA expression was clearly increased in thyroid carcinomas. Immunohistochemically, a bell-shaped response was observed with low to undetectable levels in normal tissue and in anaplastic tumors whereas differentiated thyroid carcinomas showed strong positive immunostaining for Wnt-5a. Transfection of Wnt-5a in a thyroid tumor cell line FTC-133 was able to reduce proliferation, migration, invasiveness and clonogenicity in these cells. These effects of Wnt-5a are associated with membranous b-catenin translocation and c-myc oncogene suppression and are mediated through an increase in intracellular Ca2+ release, which via CaMKII pathways promotes beta-catenin phosphorylation. Specific inhibition of beta-catenin phosphorylation by W-7, a calmodulin inhibitor, or by KN-93, a CaMKII inhibitor, supports these. findings whereas PKC inhibitors were without effect. This interaction occurs downstream of GSK-3 beta as no Wnt-5a effect was seen on the Ser(9) phosphorylation of GSK-3 beta. Our data are compatible with the hypothesis that Wnt-5a serves as an antagonist to the canonical Wnt- signaling pathway with tumor suppressor activity in differentiated thyroid carcinomas.
Ämnesord och genrebeteckningar
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
- Wnt
- beta-catenin
- tumor suppression
- thyroid cancer
Biuppslag (personer, institutioner, konferenser, titlar ...)
- von Wasielewski, R (författare)
- Rao, AS (författare)
- Schofl, C (författare)
- Andersson, TommyLund University,Lunds universitet,Experimentell patologi, Malmö,Forskargrupper vid Lunds universitet,Experimental Pathology, Malmö,Lund University Research Groups(Swepub:lu)expp-tan (författare)
- Brabant, G (författare)
- Experimentell patologi, MalmöForskargrupper vid Lunds universitet (creator_code:org_t)
Sammanhörande titlar
- Ingår i:Oncogene: Springer Science and Business Media LLC24:13, s. 2144-21541476-55940950-9232
Internetlänk
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- Kremenevskaja, N
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- Rao, AS
- Schofl, C
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- Brabant, G
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