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Trans-ethnic kidney function association study reveals putative causal genes and effects on kidney-specific disease aetiologies

Morris, Andrew P (author)
Le, Thu H (author)
Wu, Haojia (author)
show more...
Akbarov, Artur (author)
van der Most, Peter J (author)
Hemani, Gibran (author)
Smith, George Davey (author)
Mahajan, Anubha (author)
Gaulton, Kyle J (author)
Nadkarni, Girish N (author)
Valladares-Salgado, Adan (author)
Wacher-Rodarte, Niels (author)
Mychaleckyj, Josyf C (author)
Dueker, Nicole D (author)
Guo, Xiuqing (author)
Hai, Yang (author)
Haessler, Jeffrey (author)
Kamatani, Yoichiro (author)
Stilp, Adrienne M (author)
Zhu, Gu (author)
Cook, James P (author)
Ärnlöv, Johan (author)
Karolinska Institutet,Högskolan Dalarna,Uppsala universitet,Centrum för klinisk forskning Dalarna,Medicinsk vetenskap
Blanton, Susan H (author)
de Borst, Martin H (author)
Bottinger, Erwin P (author)
Buchanan, Thomas A (author)
Cechova, Sylvia (author)
Charchar, Fadi J (author)
Chu, Pei-Lun (author)
Damman, Jeffrey (author)
Eales, James (author)
Gharavi, Ali G (author)
Giedraitis, Vilmantas (author)
Uppsala universitet,Geriatrik
Heath, Andrew C (author)
Ipp, Eli (author)
Kiryluk, Krzysztof (author)
Kramer, Holly J (author)
Kubo, Michiaki (author)
Larsson, Anders (author)
Uppsala universitet,Klinisk kemi
Lindgren, Cecilia M (author)
Lu, Yingchang (author)
Madden, Pamela A F (author)
Montgomery, Grant W (author)
Papanicolaou, George J (author)
Raffel, Leslie J (author)
Sacco, Ralph L (author)
Sanchez, Elena (author)
Stark, Holger (author)
Sundström, Johan, Professor, 1971- (author)
Uppsala universitet,Molekylär epidemiologi
Taylor, Kent D (author)
Xiang, Anny H (author)
Zivkovic, Aleksandra (author)
Lind, Lars (author)
Uppsala universitet,Klinisk epidemiologi
Ingelsson, Erik, 1975- (author)
Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab,Stanford Univ, Dept Med, Div Cardiovasc Med, Sch Med, Stanford, Stanford Univ, Stanford Cardiovasc Inst, Stanford, USA; Stanford Univ, Stanford Diabet Res Ctr, Stanford, USA
Martin, Nicholas G (author)
Whitfield, John B (author)
Cai, Jianwen (author)
Laurie, Cathy C (author)
Okada, Yukinori (author)
Matsuda, Koichi (author)
Kooperberg, Charles (author)
Chen, Yii-Der Ida (author)
Rundek, Tatjana (author)
Rich, Stephen S (author)
Loos, Ruth J F (author)
Parra, Esteban J (author)
Cruz, Miguel (author)
Rotter, Jerome I (author)
Snieder, Harold (author)
Tomaszewski, Maciej (author)
Humphreys, Benjamin D (author)
Franceschini, Nora (author)
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 (creator_code:org_t)
2019-01-03
2019
English.
In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10:1
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Chronic kidney disease (CKD) affects ~10% of the global population, with considerable ethnic differences in prevalence and aetiology. We assemble genome-wide association studies of estimated glomerular filtration rate (eGFR), a measure of kidney function that defines CKD, in 312,468 individuals of diverse ancestry. We identify 127 distinct association signals with homogeneous effects on eGFR across ancestries and enrichment in genomic annotations including kidney-specific histone modifications. Fine-mapping reveals 40 high-confidence variants driving eGFR associations and highlights putative causal genes with cell-type specific expression in glomerulus, and in proximal and distal nephron. Mendelian randomisation supports causal effects of eGFR on overall and cause-specific CKD, kidney stone formation, diastolic blood pressure and hypertension. These results define novel molecular mechanisms and putative causal genes for eGFR, offering insight into clinical outcomes and routes to CKD treatment development.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

Keyword

Hälsa och välfärd

Publication and Content Type

ref (subject category)
art (subject category)

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By the author/editor
Morris, Andrew P
Le, Thu H
Wu, Haojia
Akbarov, Artur
van der Most, Pe ...
Hemani, Gibran
show more...
Smith, George Da ...
Mahajan, Anubha
Gaulton, Kyle J
Nadkarni, Girish ...
Valladares-Salga ...
Wacher-Rodarte, ...
Mychaleckyj, Jos ...
Dueker, Nicole D
Guo, Xiuqing
Hai, Yang
Haessler, Jeffre ...
Kamatani, Yoichi ...
Stilp, Adrienne ...
Zhu, Gu
Cook, James P
Ärnlöv, Johan
Blanton, Susan H
de Borst, Martin ...
Bottinger, Erwin ...
Buchanan, Thomas ...
Cechova, Sylvia
Charchar, Fadi J
Chu, Pei-Lun
Damman, Jeffrey
Eales, James
Gharavi, Ali G
Giedraitis, Vilm ...
Heath, Andrew C
Ipp, Eli
Kiryluk, Krzyszt ...
Kramer, Holly J
Kubo, Michiaki
Larsson, Anders
Lindgren, Cecili ...
Lu, Yingchang
Madden, Pamela A ...
Montgomery, Gran ...
Papanicolaou, Ge ...
Raffel, Leslie J
Sacco, Ralph L
Sanchez, Elena
Stark, Holger
Sundström, Johan ...
Taylor, Kent D
Xiang, Anny H
Zivkovic, Aleksa ...
Lind, Lars
Ingelsson, Erik, ...
Martin, Nicholas ...
Whitfield, John ...
Cai, Jianwen
Laurie, Cathy C
Okada, Yukinori
Matsuda, Koichi
Kooperberg, Char ...
Chen, Yii-Der Id ...
Rundek, Tatjana
Rich, Stephen S
Loos, Ruth J F
Parra, Esteban J
Cruz, Miguel
Rotter, Jerome I
Snieder, Harold
Tomaszewski, Mac ...
Humphreys, Benja ...
Franceschini, No ...
show less...
About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Health Sciences
and Public Health Gl ...
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
Articles in the publication
Nature Communica ...
By the university
Uppsala University
Högskolan Dalarna
Karolinska Institutet

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