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Genetic variants on...
Genetic variants on chromosomes 7p31 and 12p12 are associated with abnormal atrial electrical activation in patients with early-onset lone atrial fibrillation
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- Seifert, Mariam B. (författare)
- Lund University,Lunds universitet,Electrocardiology Research Group - CIEL,Forskargrupper vid Lunds universitet,Lund University Research Groups,Frederiksberg Hospital,Skåne University Hospital
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- Olesen, Morten S. (författare)
- University of Copenhagen,Danish National Research Foundation Centre for Cardiac Arrhythmia
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- Christophersen, Ingrid E. (författare)
- Baerum Hospital,Oslo university hospital
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- Nielsen, Jonas B. (författare)
- University of Copenhagen,Danish National Research Foundation Centre for Cardiac Arrhythmia
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- Carlson, Jonas (författare)
- Lund University,Lunds universitet,Electrocardiology Research Group - CIEL,Forskargrupper vid Lunds universitet,Lund University Research Groups,Skåne University Hospital
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- Holmqvist, Fredrik (författare)
- Lund University,Lunds universitet,Electrocardiology Research Group - CIEL,Forskargrupper vid Lunds universitet,Lund University Research Groups,Skåne University Hospital
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- Tveit, Arnljot (författare)
- Baerum Hospital
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- Haunsø, Stig (författare)
- University of Copenhagen,Danish National Research Foundation Centre for Cardiac Arrhythmia
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- Svendsen, Jesper H. (författare)
- University of Copenhagen,Danish National Research Foundation Centre for Cardiac Arrhythmia
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- Platonov, Pyotr G. (författare)
- Lund University,Lunds universitet,Electrocardiology Research Group - CIEL,Forskargrupper vid Lunds universitet,Lund University Research Groups,Skåne University Hospital
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(creator_code:org_t)
- 2019-06
- 2019
- Engelska.
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Ingår i: Annals of Noninvasive Electrocardiology. - : Wiley. - 1082-720X .- 1542-474X. ; 24:6
- Relaterad länk:
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http://dx.doi.org/10...
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https://onlinelibrar...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Background: Abnormal P-wave morphology (PWM) has been associated with a history of atrial fibrillation (AF) in earlier studies. Although lone AF is believed to have substantial genetic basis, studies on associations between single nucleotide polymorphisms (SNP) linked to lone AF and PWM have not been reported. We aimed to assess whether SNPs previously associated with lone AF (rs2200733, rs13376333, rs3807989, and rs11047543) are also linked to P-wave abnormalities. Methods: Four SNPs were studied in 176 unrelated individuals with early-onset lone AF (age at onset <50 years), median age 38 years (19–63 years), 149 men. Using sinus rhythm ECG, orthogonal PWM was classified as Type 1—positive in leads X and Y and negative in lead Z, Type 2—positive in leads X and Y and biphasic (−/+) in lead Z, Type 3—positive in lead X and biphasic in lead Y (+/−), and the remaining as atypical. Results: Two SNPs were found to be significantly associated with altered P-wave morphology distribution: rs3807989 near the gene CAV1/CAV2 and rs11047543 near the gene SOX5. Both SNPs were associated with a higher risk of non-Type 1 P-wave morphology (rs3807989: OR = 4.8, 95% CI = 2.3–10.2, p < 0.001; rs11047543: OR = 4.7, 95% CI = 1.1–20.5, p = 0.04). No association was observed for rs2200733 and rs13376333. Conclusion: In this study, the two variants rs3807989 and rs11047543, previously associated with PR interval and lone AF, were associated with altered P-wave morphology distribution in patients with early-onset lone AF. These findings suggest that common genetic variants may modify atrial conduction properties.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- atrial fibrillation
- P-wave morphology
- SNP
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Seifert, Mariam ...
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Olesen, Morten S ...
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Christophersen, ...
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Nielsen, Jonas B ...
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Carlson, Jonas
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Holmqvist, Fredr ...
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Tveit, Arnljot
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Haunsø, Stig
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Svendsen, Jesper ...
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Platonov, Pyotr ...
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- MEDICIN OCH HÄLSOVETENSKAP
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och Klinisk medicin
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Annals of Noninv ...
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Lunds universitet